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Consensus document of an expert group from the Spanish Society of Arteriosclerosis (SEA) on the clinical use of nuclear magnetic resonance to assess lipoprotein metabolism (Liposcale®)

  • Datos identificativos

    Identificador: imarina:7474170
    Autores:
    Pintó XMasana LCiveira FReal JIbarretxe DCandas BPuzo JDíaz JLAmigó NEsteban MValdivielso P
    Resumen:
    © 2020 The Authors The assessment and prevention of cardiovascular risk (CVR) that persists in patients with dyslipidaemia despite treatment and achievement of goals specific to the plasma concentration of cholesterol linked to low density (c-LDL) is a clinical challenge today, and suggests that conventional lipid biomarkers are insufficient for an accurate assessment of CVR. Apart from their lipid content, there are other lipid particle characteristics. The results of this study show that there are a number of lipoprotein compounds that determine atherogenic potential and its influence on the CVR. However, such additional characteristics cannot be analysed by the techniques commonly used in clinical laboratories. Nuclear Magnetic Resonance (NMR) is a technique that allows a detailed analysis to be made of the amount, composition, and size of lipoproteins, as well as providing more information about the detailed status of lipid metabolism and CVR in dyslipidaemia patients. In this article a group of lipidologists from the Spanish Society of Arteriosclerosis review the existing evidence on the atherogenic mechanisms of particles and describe the technical basis and interpretation of the profiles lipoproteins obtained by MRI, with special reference to the test available in Spain (Liposcale®). Likewise, the main patient profiles are defined as such that an analysis would provide information of greater clinical interest. These include: a) Suspected mismatch between lipid concentrations and particles, a common situation in diabetes, obesity, metabolic syndrome; b) Early atherothrombotic cardiovascular disease (ECVA) or recurrent without CVR factors to justify it; c) Lipid disorders, rare or complex, such as extreme concentrations of c-HDL, and d) Clinical situations where cl
  • Otros:

    Autor según el artículo: Pintó X; Masana L; Civeira F; Real J; Ibarretxe D; Candas B; Puzo J; Díaz JL; Amigó N; Esteban M; Valdivielso P
    Departamento: Medicina i Cirurgia
    Autor/es de la URV: Ibarretxe Gerediaga, Daiana / Masana Marín, Luis
    Palabras clave: Risk-factors Riesgo cardiovascular Remnant cholesterol Non-hdl cholesterol Low-density-lipoprotein Lipoproteins Lipoprotein particles Lipid-lowering therapy Ldl particle number Cardiovascular-disease Cardiovascular risk B-containing lipoproteins Apolipoprotein-b A-i resonancia magnética nuclear partículas lipoproteicas lipoproteins lipoproteínas lipoprotein particles cardiovascular risk
    Resumen: © 2020 The Authors The assessment and prevention of cardiovascular risk (CVR) that persists in patients with dyslipidaemia despite treatment and achievement of goals specific to the plasma concentration of cholesterol linked to low density (c-LDL) is a clinical challenge today, and suggests that conventional lipid biomarkers are insufficient for an accurate assessment of CVR. Apart from their lipid content, there are other lipid particle characteristics. The results of this study show that there are a number of lipoprotein compounds that determine atherogenic potential and its influence on the CVR. However, such additional characteristics cannot be analysed by the techniques commonly used in clinical laboratories. Nuclear Magnetic Resonance (NMR) is a technique that allows a detailed analysis to be made of the amount, composition, and size of lipoproteins, as well as providing more information about the detailed status of lipid metabolism and CVR in dyslipidaemia patients. In this article a group of lipidologists from the Spanish Society of Arteriosclerosis review the existing evidence on the atherogenic mechanisms of particles and describe the technical basis and interpretation of the profiles lipoproteins obtained by MRI, with special reference to the test available in Spain (Liposcale®). Likewise, the main patient profiles are defined as such that an analysis would provide information of greater clinical interest. These include: a) Suspected mismatch between lipid concentrations and particles, a common situation in diabetes, obesity, metabolic syndrome; b) Early atherothrombotic cardiovascular disease (ECVA) or recurrent without CVR factors to justify it; c) Lipid disorders, rare or complex, such as extreme concentrations of c-HDL, and d) Clinical situations where classical analytical techniques cannot be applied, such as very low c-LDL values.
    Áreas temáticas: Pharmacology (medical) Peripheral vascular disease Medicina iii Medicina i Cardiology and cardiovascular medicine
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 15781879
    Direcció de correo del autor: daiana.ibarretxe@urv.cat luis.masana@urv.cat
    Identificador del autor: 0000-0002-0789-4954
    Fecha de alta del registro: 2024-08-24
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    Enlace a la fuente original: https://www.sciencedirect.com/science/article/pii/S0214916820300474
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referencia al articulo segun fuente origial: Clinica E Investigacion En Arteriosclerosis. 32 (5): 219-229
    Referencia de l'ítem segons les normes APA: Pintó X; Masana L; Civeira F; Real J; Ibarretxe D; Candas B; Puzo J; Díaz JL; Amigó N; Esteban M; Valdivielso P (2020). Consensus document of an expert group from the Spanish Society of Arteriosclerosis (SEA) on the clinical use of nuclear magnetic resonance to assess lipoprotein metabolism (Liposcale®). Clinica E Investigacion En Arteriosclerosis, 32(5), 219-229. DOI: 10.1016/j.arteri.2020.04.004
    DOI del artículo: 10.1016/j.arteri.2020.04.004
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2020
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Cardiology and Cardiovascular Medicine,Peripheral Vascular Disease,Pharmacology (Medical)
    Risk-factors
    Riesgo cardiovascular
    Remnant cholesterol
    Non-hdl cholesterol
    Low-density-lipoprotein
    Lipoproteins
    Lipoprotein particles
    Lipid-lowering therapy
    Ldl particle number
    Cardiovascular-disease
    Cardiovascular risk
    B-containing lipoproteins
    Apolipoprotein-b
    A-i
    resonancia magnética nuclear
    partículas lipoproteicas
    lipoproteins
    lipoproteínas
    lipoprotein particles
    cardiovascular risk
    Pharmacology (medical)
    Peripheral vascular disease
    Medicina iii
    Medicina i
    Cardiology and cardiovascular medicine
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