Acute Effects of Turmeric Extracts on Knee Joint Pain: A Pilot

Identificador:  imarina:7742807

Handle: https://hdl.handle.net/20.500.11797/imarina7742807

Autors:  Calderon-Perez, Lorena; Llaurado, Elisabet; Companys, Judit; Pla-Paga, Laura; Boque, Noemi; Puiggros, Francesc; Valls, Rosa-M; Pedret, Anna; Manuel Llabres, Josep; Arola, Lluis; Sola, Rosa

Resum:
Turmeric extracts (TEs) have been shown to be suitable as a pain treatment for human joint arthritis. In a pilot, randomized clinical trial, 68 individuals with mild/moderate knee joint pain (KJP) consumed a new formulation of water-soluble TEs and insoluble curcuminoids (B-Turmactive(R)) or brewer's yeast as a placebo for 1 week. Our hypothesis was that B-Turmactive would have a short-term analgesic effect on KJP measured by the self-reported Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). After 3 days and 1 week, both treatments reduced pain when walking on a flat surface (P < .01), going up or down stairs (P < .001), and sitting or lying (P < .05), but only B-Turmactive reduced pain at night while in bed and in an upright standing position (P < .01). Concerning global KJP, it was reduced by both treatments after 3 days and 1 week of the intervention (P < .001), being less with B-Turmactive after 1 week (P = .012 vs. 3 weeks). Although no intertreatment differences were observed, only B-Turmactive decreased high-sensitivity C-reactive protein levels (P = .045) at 1 week, which indicates a prompt analgesic effect mediated by a decrease in inflammatory status.