Articles producció científica> Medicina i Cirurgia

Acute Effects of Turmeric Extracts on Knee Joint Pain: A Pilot, Randomized Controlled Trial

  • Dades identificatives

    Identificador: imarina:7742807
    Autors:
    Calderon-Perez, LorenaLlaurado, ElisabetCompanys, JuditPla-Paga, LauraBoque, NoemiPuiggros, FrancescValls, Rosa-MPedret, AnnaManuel Llabres, JosepArola, LluisSola, Rosa
    Resum:
    Turmeric extracts (TEs) have been shown to be suitable as a pain treatment for human joint arthritis. In a pilot, randomized clinical trial, 68 individuals with mild/moderate knee joint pain (KJP) consumed a new formulation of water-soluble TEs and insoluble curcuminoids (B-Turmactive(R)) or brewer's yeast as a placebo for 1 week. Our hypothesis was that B-Turmactive would have a short-term analgesic effect on KJP measured by the self-reported Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). After 3 days and 1 week, both treatments reduced pain when walking on a flat surface (P < .01), going up or down stairs (P < .001), and sitting or lying (P < .05), but only B-Turmactive reduced pain at night while in bed and in an upright standing position (P < .01). Concerning global KJP, it was reduced by both treatments after 3 days and 1 week of the intervention (P < .001), being less with B-Turmactive after 1 week (P = .012 vs. 3 weeks). Although no intertreatment differences were observed, only B-Turmactive decreased high-sensitivity C-reactive protein levels (P = .045) at 1 week, which indicates a prompt analgesic effect mediated by a decrease in inflammatory status.
  • Altres:

    Autor segons l'article: Calderon-Perez, Lorena; Llaurado, Elisabet; Companys, Judit; Pla-Paga, Laura; Boque, Noemi; Puiggros, Francesc; Valls, Rosa-M; Pedret, Anna; Manuel Llabres, Josep; Arola, Lluis; Sola, Rosa;
    Departament: Medicina i Cirurgia
    Autor/s de la URV: Arola Ferrer, Luis Maria / Calderon Pérez, Lorena / Companys Alemany, Judit / Llauradó Ribé, Elisabet / Pedret Figuerola, Anna / PLA PAGA, LAURA / Solà Alberich, Rosa Maria / Valls Zamora, Rosa Maria
    Paraules clau: Turmeric extracts Treatment outcome Symptoms Randomized controlled trial Plant extracts Plant extract Painkiller Pain Osteoarthritis, knee Metaanalysis Knee osteoarthritis Knee joint pain Knee joint Knee Humans Human Formulation Double-blind method Double-blind Double blind procedure Curcumin Curcuma longa Curcuma Controlled study Clinical-use Brewer's yeast Arthritis Arthralgia painkiller knee joint pain curcuma longa brewer's yeast
    Resum: Turmeric extracts (TEs) have been shown to be suitable as a pain treatment for human joint arthritis. In a pilot, randomized clinical trial, 68 individuals with mild/moderate knee joint pain (KJP) consumed a new formulation of water-soluble TEs and insoluble curcuminoids (B-Turmactive(R)) or brewer's yeast as a placebo for 1 week. Our hypothesis was that B-Turmactive would have a short-term analgesic effect on KJP measured by the self-reported Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). After 3 days and 1 week, both treatments reduced pain when walking on a flat surface (P < .01), going up or down stairs (P < .001), and sitting or lying (P < .05), but only B-Turmactive reduced pain at night while in bed and in an upright standing position (P < .01). Concerning global KJP, it was reduced by both treatments after 3 days and 1 week of the intervention (P < .001), being less with B-Turmactive after 1 week (P = .012 vs. 3 weeks). Although no intertreatment differences were observed, only B-Turmactive decreased high-sensitivity C-reactive protein levels (P = .045) at 1 week, which indicates a prompt analgesic effect mediated by a decrease in inflammatory status.
    Àrees temàtiques: Zootecnia / recursos pesqueiros Química Planejamento urbano e regional / demografia Odontología Nutrition and dietetics Nutrition & dietetics Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Food science & technology Farmacia Ensino Engenharias iv Engenharias ii Educação física Educação Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Chemistry, medicinal Biotecnología Biodiversidade Astronomia / física
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 1096620X
    Adreça de correu electrònic de l'autor: lorena.calderon@urv.cat judit.companys@urv.cat anna.pedret@urv.cat elisabet.llaurado@urv.cat judit.companys@urv.cat judit.companys@urv.cat lorena.calderon@urv.cat rosamaria.valls@urv.cat rosa.sola@urv.cat lluis.arola@urv.cat
    Identificador de l'autor: 0000-0003-0766-0733 0000-0003-1485-0818 0000-0002-5327-932X 0000-0002-7439-9531 0000-0003-1485-0818 0000-0003-1485-0818 0000-0003-0766-0733 0000-0002-3351-0942 0000-0002-8359-235X 0000-0003-2767-1974
    Data d'alta del registre: 2024-07-27
    Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
    Enllaç font original: https://www.liebertpub.com/doi/full/10.1089/jmf.2020.0074
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referència a l'article segons font original: Journal Of Medicinal Food. 24 (4): 436-440
    Referència de l'ítem segons les normes APA: Calderon-Perez, Lorena; Llaurado, Elisabet; Companys, Judit; Pla-Paga, Laura; Boque, Noemi; Puiggros, Francesc; Valls, Rosa-M; Pedret, Anna; Manuel Ll (2021). Acute Effects of Turmeric Extracts on Knee Joint Pain: A Pilot, Randomized Controlled Trial. Journal Of Medicinal Food, 24(4), 436-440. DOI: 10.1089/jmf.2020.0074
    DOI de l'article: 10.1089/jmf.2020.0074
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2021
    Tipus de publicació: Journal Publications
  • Paraules clau:

    Chemistry, Medicinal,Food Science & Technology,Medicine (Miscellaneous),Nutrition & Dietetics,Nutrition and Dietetics
    Turmeric extracts
    Treatment outcome
    Symptoms
    Randomized controlled trial
    Plant extracts
    Plant extract
    Painkiller
    Pain
    Osteoarthritis, knee
    Metaanalysis
    Knee osteoarthritis
    Knee joint pain
    Knee joint
    Knee
    Humans
    Human
    Formulation
    Double-blind method
    Double-blind
    Double blind procedure
    Curcumin
    Curcuma longa
    Curcuma
    Controlled study
    Clinical-use
    Brewer's yeast
    Arthritis
    Arthralgia
    painkiller
    knee joint pain
    curcuma longa
    brewer's yeast
    Zootecnia / recursos pesqueiros
    Química
    Planejamento urbano e regional / demografia
    Odontología
    Nutrition and dietetics
    Nutrition & dietetics
    Nutrição
    Medicine (miscellaneous)
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Materiais
    Interdisciplinar
    Food science & technology
    Farmacia
    Ensino
    Engenharias iv
    Engenharias ii
    Educação física
    Educação
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência de alimentos
    Chemistry, medicinal
    Biotecnología
    Biodiversidade
    Astronomia / física
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