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Plasma Metabolomic Profiling Associates Bicuspid Aortic Valve Disease and Ascending Aortic Dilation with a Decrease in Antioxidant Capacity dagger

  • Dades identificatives

    Identificador: imarina:7742811
    Autors:
    Martinez-Micaelo, NeusLigero, CarmeAntequera-Gonzalez, BorjaJunza, AlexandraYanes, OscarAlegret, Josep M
    Resum:
    Background: The bicuspid aortic valve (BAV) is the most common cardiac congenital disease and is associated with an increased risk of developing ascending aorta dilation; which can have fatal consequences. Currently; no established risk biomarkers exist to facilitate the diagnosis and prognosis of BAV. Methods: Using an untargeted metabolomic approach; we identified the levels of metabolites in plasma samples and compared them depending on the bicuspid or tricuspid morphology of the aortic valve. Including those patients with ascending aortic dilation and/or aortic stenosis (n= 212), we analyzed the role possibly played by alpha-Tocopherol in BAV disease; considering its association with the pathophysiological characteristics of BAV and biomarkers related to inflammation, oxidative stress and endothelial damage, as well as characteristics related to alpha-Tocopherol functionality and metabolism. Results: We found that BAV patients; especially those with ascending aortic dilation; presented lower antioxidant capacity; as determined by decreased plasma levels of alpha-Tocopherol; paraoxonase 1 and high-density lipoprotein (HDL), as well as increased levels of C-reactive protein (CRP; a biomarker of inflammation) and endothelial microparticles (EMPs; an endothelial damage biomarker). By applying random forest analyses; we evaluated the significant screening capacity of alpha-Tocopherol; CRP and EMPs to classify patients depending on the morphology of the aortic valve. Discussion: Our findings support the role of decreased antioxidant capacity; increased inflammation and endothelial damage in the pathogenesis of BAV and the progression of aortic dilation. Moreover; determining the plasma levels of alpha-Tocopherol; CRP and EMPs could improve BAV diagnosis in large populatio
  • Altres:

    Autor segons l'article: Martinez-Micaelo, Neus; Ligero, Carme; Antequera-Gonzalez, Borja; Junza, Alexandra; Yanes, Oscar; Alegret, Josep M
    Departament: Enginyeria Electrònica, Elèctrica i Automàtica Medicina i Cirurgia
    Autor/s de la URV: Alegret Colomé, Josep Maria / Antequera González, Borja / Junza Martínez, Alexandra / Martínez Micaelo, Nieves Beatriz / Yanes Torrado, Óscar
    Paraules clau: Wall shear-stress Tocopherol Metabolomics Lipid-metabolism Inflammation Flow patterns Dilatation Choline Bicuspid aortic valve Ascending aortic dilation Antioxidant Alpha-tocopherol inflammation bicuspid aortic valve ascending aortic dilation antioxidant alpha-tocopherol
    Resum: Background: The bicuspid aortic valve (BAV) is the most common cardiac congenital disease and is associated with an increased risk of developing ascending aorta dilation; which can have fatal consequences. Currently; no established risk biomarkers exist to facilitate the diagnosis and prognosis of BAV. Methods: Using an untargeted metabolomic approach; we identified the levels of metabolites in plasma samples and compared them depending on the bicuspid or tricuspid morphology of the aortic valve. Including those patients with ascending aortic dilation and/or aortic stenosis (n= 212), we analyzed the role possibly played by alpha-Tocopherol in BAV disease; considering its association with the pathophysiological characteristics of BAV and biomarkers related to inflammation, oxidative stress and endothelial damage, as well as characteristics related to alpha-Tocopherol functionality and metabolism. Results: We found that BAV patients; especially those with ascending aortic dilation; presented lower antioxidant capacity; as determined by decreased plasma levels of alpha-Tocopherol; paraoxonase 1 and high-density lipoprotein (HDL), as well as increased levels of C-reactive protein (CRP; a biomarker of inflammation) and endothelial microparticles (EMPs; an endothelial damage biomarker). By applying random forest analyses; we evaluated the significant screening capacity of alpha-Tocopherol; CRP and EMPs to classify patients depending on the morphology of the aortic valve. Discussion: Our findings support the role of decreased antioxidant capacity; increased inflammation and endothelial damage in the pathogenesis of BAV and the progression of aortic dilation. Moreover; determining the plasma levels of alpha-Tocopherol; CRP and EMPs could improve BAV diagnosis in large populations.
    Àrees temàtiques: Medicine, general & internal Medicine (miscellaneous) Medicine (all)
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 20770383
    Adreça de correu electrònic de l'autor: oscar.yanes@urv.cat neus.martinez@urv.cat alexandra.junza@urv.cat borja.antequera@estudiants.urv.cat borja.antequera@estudiants.urv.cat josepmaria.alegret@urv.cat
    Identificador de l'autor: 0000-0003-3695-7157 0000-0001-7205-0419 0000-0002-6117-5512
    Data d'alta del registre: 2024-10-12
    Volum de revista: 9
    Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
    Enllaç font original: https://www.mdpi.com/2077-0383/9/7/2215
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referència a l'article segons font original: Journal Of Clinical Medicine. 9 (7): 2215-12
    Referència de l'ítem segons les normes APA: Martinez-Micaelo, Neus; Ligero, Carme; Antequera-Gonzalez, Borja; Junza, Alexandra; Yanes, Oscar; Alegret, Josep M (2020). Plasma Metabolomic Profiling Associates Bicuspid Aortic Valve Disease and Ascending Aortic Dilation with a Decrease in Antioxidant Capacity dagger. Journal Of Clinical Medicine, 9(7), 2215-12. DOI: 10.3390/jcm9072215
    DOI de l'article: 10.3390/jcm9072215
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2020
    Tipus de publicació: Journal Publications
  • Paraules clau:

    Medicine (Miscellaneous),Medicine, General & Internal
    Wall shear-stress
    Tocopherol
    Metabolomics
    Lipid-metabolism
    Inflammation
    Flow patterns
    Dilatation
    Choline
    Bicuspid aortic valve
    Ascending aortic dilation
    Antioxidant
    Alpha-tocopherol
    inflammation
    bicuspid aortic valve
    ascending aortic dilation
    antioxidant
    alpha-tocopherol
    Medicine, general & internal
    Medicine (miscellaneous)
    Medicine (all)
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