Autor segons l'article: Diaz-Lopez, Andres; Bullo, Monica; Chacon, Matilde R; Estruch, Ramon; Vendrell, Joan; Diez-Espino, Javier; Fito, Montserrat; Corella, Dolores; Salas-Salvado, Jordi
Departament: Medicina i Cirurgia Bioquímica i Biotecnologia
Autor/s de la URV: Bulló Bonet, Mònica / Díaz López, Andres / Rodríguez Chacón, Matilde / Salas Salvadó, Jorge / VENDRELL FERRE, JOAN / Vendrell Ortega, Juan José
Paraules clau: Stweak Metabolic syndrome Insulin resistance Cardiovascular risk Biomarkers
Resum: The circulating soluble TNF-like weak inducer of apoptosis (sTWEAK) is a cytokine that modulates inflammatory and atherogenic reactions related to cardiometabolic risk. We investigated the association between sTWEAK levels and metabolic syndrome (MetS) and its components in older subjects at high cardiovascular risk.Cross-sectional analysis of 452 non-diabetic individuals (men and women aged 55-80 years) at high cardiovascular risk. MetS was defined by AHA/NHLBI and IDF criteria. Logistic regression analyses were used to estimate odds ratios (ORs) for MetS and its components by tertiles of serum sTWEAK concentrations measured by ELISA.sTWEAK concentrations were lower in subjects with MetS than in those without. In gender- and age-adjusted analyses, subjects in the lowest sTWEAK tertile had higher ORs for overall MetS [1.71 (95% CI, 1.07-2.72)] and its components abdominal obesity [2.01 (1.15-3.52)], hyperglycemia [1.94 (1.20-3.11)], and hypertriglyceridemia [1.73 (1.05-2.82)] than those in the upper tertile. These associations persisted after controlling for family history of diabetes and premature coronary heart disease, lifestyle, kidney function and other MetS components. sTWEAK concentrations decreased as the number of MetS components increased. Individuals in the lowest vs the upper sTWEAK tertile had an increased risk of disclosing greater number of MetS features. Adjusted ORs for individuals with 2 vs ?1, 3 vs ?1, and ?4 vs???1 MetS components were 2.60 (1.09-6.22), 2.83 (1.16-6.87) and 6.39 (2.42-16.85), respectively.In older subjects at high cardiovascular risk, reduced sTWEAK levels are associated with MetS: abdominal obesity, hypertriglyceridemia and hyperglycemia are the main contributors to this association.
Àrees temàtiques: Saúde coletiva Medicina ii Medicina i Internal medicine Interdisciplinar Farmacia Endocrinology, diabetes and metabolism Endocrinology & metabolism Educação física Ciências biológicas ii Ciências biológicas i Cardiology and cardiovascular medicine Cardiac & cardiovascular systems Biotecnología
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 14752840
Adreça de correu electrònic de l'autor: andres.diaz@urv.cat matilde.rodriguez@urv.cat monica.bullo@urv.cat jordi.salas@urv.cat juanjose.vendrell@urv.cat
Identificador de l'autor: 0000-0002-7500-5629 0000-0002-0218-7046 0000-0003-2700-7459 0000-0002-6994-6115
Data d'alta del registre: 2024-10-12
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
Enllaç font original: https://cardiab.biomedcentral.com/articles/10.1186/1475-2840-13-51
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: Cardiovascular Diabetology. 13 (1): 51-
Referència de l'ítem segons les normes APA: Diaz-Lopez, Andres; Bullo, Monica; Chacon, Matilde R; Estruch, Ramon; Vendrell, Joan; Diez-Espino, Javier; Fito, Montserrat; Corella, Dolores; Salas-S (2014). Reduced circulating sTWEAK levels are associated with metabolic syndrome in elderly individuals at high cardiovascular risk. Cardiovascular Diabetology, 13(1), 51-. DOI: 10.1186/1475-2840-13-51
DOI de l'article: 10.1186/1475-2840-13-51
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2014
Tipus de publicació: Journal Publications
Repositori URV