Author, as appears in the article.: Diaz-Lopez, Andres; Bullo, Monica; Chacon, Matilde R; Estruch, Ramon; Vendrell, Joan; Diez-Espino, Javier; Fito, Montserrat; Corella, Dolores; Salas-Salvado, Jordi
Department: Medicina i Cirurgia Bioquímica i Biotecnologia
URV's Author/s: Bulló Bonet, Mònica / Díaz López, Andres / Rodríguez Chacón, Matilde / Salas Salvadó, Jorge / VENDRELL FERRE, JOAN / Vendrell Ortega, Juan José
Keywords: Stweak Metabolic syndrome Insulin resistance Cardiovascular risk Biomarkers
Abstract: The circulating soluble TNF-like weak inducer of apoptosis (sTWEAK) is a cytokine that modulates inflammatory and atherogenic reactions related to cardiometabolic risk. We investigated the association between sTWEAK levels and metabolic syndrome (MetS) and its components in older subjects at high cardiovascular risk.Cross-sectional analysis of 452 non-diabetic individuals (men and women aged 55-80 years) at high cardiovascular risk. MetS was defined by AHA/NHLBI and IDF criteria. Logistic regression analyses were used to estimate odds ratios (ORs) for MetS and its components by tertiles of serum sTWEAK concentrations measured by ELISA.sTWEAK concentrations were lower in subjects with MetS than in those without. In gender- and age-adjusted analyses, subjects in the lowest sTWEAK tertile had higher ORs for overall MetS [1.71 (95% CI, 1.07-2.72)] and its components abdominal obesity [2.01 (1.15-3.52)], hyperglycemia [1.94 (1.20-3.11)], and hypertriglyceridemia [1.73 (1.05-2.82)] than those in the upper tertile. These associations persisted after controlling for family history of diabetes and premature coronary heart disease, lifestyle, kidney function and other MetS components. sTWEAK concentrations decreased as the number of MetS components increased. Individuals in the lowest vs the upper sTWEAK tertile had an increased risk of disclosing greater number of MetS features. Adjusted ORs for individuals with 2 vs ?1, 3 vs ?1, and ?4 vs???1 MetS components were 2.60 (1.09-6.22), 2.83 (1.16-6.87) and 6.39 (2.42-16.85), respectively.In older subjects at high cardiovascular risk, reduced sTWEAK levels are associated with MetS: abdominal obesity, hypertriglyceridemia and hyperglycemia are the main contributors to this association.
Thematic Areas: Saúde coletiva Medicina ii Medicina i Internal medicine Interdisciplinar Farmacia Endocrinology, diabetes and metabolism Endocrinology & metabolism Educação física Ciências biológicas ii Ciências biológicas i Cardiology and cardiovascular medicine Cardiac & cardiovascular systems Biotecnología
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 14752840
Author's mail: andres.diaz@urv.cat matilde.rodriguez@urv.cat monica.bullo@urv.cat jordi.salas@urv.cat jvortega@iispv.cat
Author identifier: 0000-0002-7500-5629 0000-0002-0218-7046 0000-0003-2700-7459 0000-0002-6994-6115
Record's date: 2024-11-09
Papper version: info:eu-repo/semantics/publishedVersion
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Cardiovascular Diabetology. 13 (1): 51-
APA: Diaz-Lopez, Andres; Bullo, Monica; Chacon, Matilde R; Estruch, Ramon; Vendrell, Joan; Diez-Espino, Javier; Fito, Montserrat; Corella, Dolores; Salas-S (2014). Reduced circulating sTWEAK levels are associated with metabolic syndrome in elderly individuals at high cardiovascular risk. Cardiovascular Diabetology, 13(1), 51-. DOI: 10.1186/1475-2840-13-51
Entity: Universitat Rovira i Virgili
Journal publication year: 2014
Publication Type: Journal Publications
Repositori URV