Articles producció científica> Química Analítica i Química Orgànica

Determination of synthetic cathinones in urine and oral fluid by liquid chromatography high-resolution mass spectrometry and low-resolution mass spectrometry: A method comparison

  • Dades identificatives

    Identificador: imarina:9002806
    Autors:
    Pascual-Caro SBorrull FAguilar CCalull M
    Resum:
    © 2020 by the authors. Licensee MDPI, Basel, Switzerland. Synthetic cathinones have become very popular recreational drugs. Therefore, determining them in biological samples is now a matter of concern. In recent years, different methods that have been developed can determine these drugs at low-concentration levels. In general, liquid chromatography mass spectrometry detection plays an important role in these methods and the trend is to use low-resolution and high-resolution mass spectrometry. In this article, for the first time, we compare these two analyzers using an Orbitrap and a triple quadrupole mass spectrometer in order to determine a group of synthetic cathinones in urine and oral fluid samples. For this comparison, we evaluated and compared different parameters: Method detection and quantification limits, linearity, apparent recoveries, matrix effect, repeatability (intra-day), reproducibility (inter-day), and accuracy. Similar results were obtained for the two analyzers for the apparent recoveries and matrix effect. However, triple quadrupole showed higher sensitivity compared to Orbitrap for both urine and oral fluid samples. The quantification limits in urine and the detection limits in saliva were two times lower for triple quadrupole. Finally, when blind samples were analyzed to study the accuracy, similar results were obtained for both analyzers.
  • Altres:

    Autor segons l'article: Pascual-Caro S; Borrull F; Aguilar C; Calull M
    Departament: Química Analítica i Química Orgànica
    e-ISSN: 2297-8739
    Autor/s de la URV: Aguilar Anguera, Maria del Carmen / Borrull Ballarín, Francesc / Calull Blanch, Marta / Pascual Caro, Sergi
    Paraules clau: Triple-quadrupole Tandem mass spectrometry Synthetic cathinones Stimulants Solid-phase extraction Quantification Performance Orbitrap Metabolites High-resolution mass spectrometry Hair Designer drugs Biological samples Bioanalysis Abuse
    Resum: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. Synthetic cathinones have become very popular recreational drugs. Therefore, determining them in biological samples is now a matter of concern. In recent years, different methods that have been developed can determine these drugs at low-concentration levels. In general, liquid chromatography mass spectrometry detection plays an important role in these methods and the trend is to use low-resolution and high-resolution mass spectrometry. In this article, for the first time, we compare these two analyzers using an Orbitrap and a triple quadrupole mass spectrometer in order to determine a group of synthetic cathinones in urine and oral fluid samples. For this comparison, we evaluated and compared different parameters: Method detection and quantification limits, linearity, apparent recoveries, matrix effect, repeatability (intra-day), reproducibility (inter-day), and accuracy. Similar results were obtained for the two analyzers for the apparent recoveries and matrix effect. However, triple quadrupole showed higher sensitivity compared to Orbitrap for both urine and oral fluid samples. The quantification limits in urine and the detection limits in saliva were two times lower for triple quadrupole. Finally, when blind samples were analyzed to study the accuracy, similar results were obtained for both analyzers.
    Àrees temàtiques: Filtration and separation Chemistry, analytical Analytical chemistry
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    Adreça de correu electrònic de l'autor: francesc.borrull@urv.cat marta.calull@urv.cat carme.aguilar@urv.cat sergi.pascual@estudiants.urv.cat
    Identificador de l'autor: 0000-0003-2718-9336 0000-0002-5258-1949 0000-0002-5913-2599 0000-0001-8890-5100
    Data d'alta del registre: 2023-02-23
    Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
    Enllaç font original: https://www.mdpi.com/2297-8739/7/4/53
    Referència a l'article segons font original: Separations. 7 (4): 1-14
    Referència de l'ítem segons les normes APA: Pascual-Caro S; Borrull F; Aguilar C; Calull M (2020). Determination of synthetic cathinones in urine and oral fluid by liquid chromatography high-resolution mass spectrometry and low-resolution mass spectrometry: A method comparison. Separations, 7(4), 1-14. DOI: 10.3390/separations7040053
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    DOI de l'article: 10.3390/separations7040053
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2020
    Tipus de publicació: Journal Publications
  • Paraules clau:

    Analytical Chemistry,Chemistry, Analytical,Filtration and Separation
    Triple-quadrupole
    Tandem mass spectrometry
    Synthetic cathinones
    Stimulants
    Solid-phase extraction
    Quantification
    Performance
    Orbitrap
    Metabolites
    High-resolution mass spectrometry
    Hair
    Designer drugs
    Biological samples
    Bioanalysis
    Abuse
    Filtration and separation
    Chemistry, analytical
    Analytical chemistry
  • Documents:

  • Cerca a google

    Search to google scholar