Articles producció científica> Medicina i Cirurgia

Phenol-Enriched Virgin Olive Oil Promotes Macrophage-Specific Reverse Cholesterol Transport In Vivo

  • Dades identificatives

    Identificador: imarina:9002975
    Autors:
    Cedo, LidiaFernandez-Castillejo, SaraRubio, LauraMetso, JariSantos, DavidMunoz-Aguayo, DanielRivas-Urbina, AndreaTondo, MireiaMendez-Lara, Karen AlejandraFarras, MartaJauhiainen, MattiMotilva, Maria-JoseFito, MontserratBlanco-Vaca, FranciscoSola, RosaEscola-Gil, Joan Carles
    Resum:
    The intake of olive oil (OO) enriched with phenolic compounds (PCs) promotes ex vivo HDL-mediated macrophage cholesterol efflux in humans. We aimed to determine the effects of PC-enriched virgin OO on reverse cholesterol transport (RevCT) from macrophages to feces in vivo. Female C57BL/6 mice were given intragastric doses of refined OO (ROO) and a functional unrefined virgin OO enriched with its own PC (FVOO) for 14 days. Our experiments included two independent groups of mice that received intragastric doses of the phenolic extract (PE) used to prepare the FVOO and the vehicle solution (saline), as control, for 14 days. FVOO intake led to a significant increase in serum HDL cholesterol and its ability to induce macrophage cholesterol efflux in vitro when compared with ROO group. This was concomitant with the enhanced macrophage-derived [H-3]cholesterol transport to feces in vivo. PE intakeper sealso increased HDL cholesterol levels and significantly promoted in vivo macrophage-to-feces RevCT rate when compared with saline group. PE upregulated the expression of the main macrophage transporter involved in macrophage cholesterol efflux, theATP binding cassettea1. Our data provide direct evidence of the crucial role of OO PCs in the induction of macrophage-specific RevCT in vivo.
  • Altres:

    Autor segons l'article: Cedo, Lidia; Fernandez-Castillejo, Sara; Rubio, Laura; Metso, Jari; Santos, David; Munoz-Aguayo, Daniel; Rivas-Urbina, Andrea; Tondo, Mireia; Mendez-Lara, Karen Alejandra; Farras, Marta; Jauhiainen, Matti; Motilva, Maria-Jose; Fito, Montserrat; Blanco-Vaca, Francisco; Sola, Rosa; Escola-Gil, Joan Carles;
    Departament: Medicina i Cirurgia
    Autor/s de la URV: FERNÁNDEZ CASTILLEJO, SARA / Solà Alberich, Rosa Maria
    Paraules clau: Virgin olive oil Risk-factors Reverse cholesterol transport Polyphenols Phenolic compounds Mice vohf project Increases Improves Humans Hdl Expression Efflux Consumption Antioxidant
    Resum: The intake of olive oil (OO) enriched with phenolic compounds (PCs) promotes ex vivo HDL-mediated macrophage cholesterol efflux in humans. We aimed to determine the effects of PC-enriched virgin OO on reverse cholesterol transport (RevCT) from macrophages to feces in vivo. Female C57BL/6 mice were given intragastric doses of refined OO (ROO) and a functional unrefined virgin OO enriched with its own PC (FVOO) for 14 days. Our experiments included two independent groups of mice that received intragastric doses of the phenolic extract (PE) used to prepare the FVOO and the vehicle solution (saline), as control, for 14 days. FVOO intake led to a significant increase in serum HDL cholesterol and its ability to induce macrophage cholesterol efflux in vitro when compared with ROO group. This was concomitant with the enhanced macrophage-derived [H-3]cholesterol transport to feces in vivo. PE intakeper sealso increased HDL cholesterol levels and significantly promoted in vivo macrophage-to-feces RevCT rate when compared with saline group. PE upregulated the expression of the main macrophage transporter involved in macrophage cholesterol efflux, theATP binding cassettea1. Our data provide direct evidence of the crucial role of OO PCs in the induction of macrophage-specific RevCT in vivo.
    Àrees temàtiques: Pharmacology & pharmacy Medicine, research & experimental Medicine (miscellaneous) General biochemistry,genetics and molecular biology Ciencias sociales Biochemistry, genetics and molecular biology (miscellaneous) Biochemistry, genetics and molecular biology (all) Biochemistry & molecular biology
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    Adreça de correu electrònic de l'autor: rosa.sola@urv.cat
    Identificador de l'autor: 0000-0002-8359-235X
    Data d'alta del registre: 2023-04-02
    Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
    Enllaç font original: https://www.mdpi.com/2227-9059/8/8/266
    Referència a l'article segons font original: Biomedicines. 8 (8):
    Referència de l'ítem segons les normes APA: Cedo, Lidia; Fernandez-Castillejo, Sara; Rubio, Laura; Metso, Jari; Santos, David; Munoz-Aguayo, Daniel; Rivas-Urbina, Andrea; Tondo, Mireia; Mendez-L (2020). Phenol-Enriched Virgin Olive Oil Promotes Macrophage-Specific Reverse Cholesterol Transport In Vivo. Biomedicines, 8(8), -. DOI: 10.3390/biomedicines8080266
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    DOI de l'article: 10.3390/biomedicines8080266
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2020
    Tipus de publicació: Journal Publications
  • Paraules clau:

    Biochemistry & Molecular Biology,Biochemistry, Genetics and Molecular Biology (Miscellaneous),Medicine (Miscellaneous),Medicine, Research & Experimental,Pharmacology & Pharmacy
    Virgin olive oil
    Risk-factors
    Reverse cholesterol transport
    Polyphenols
    Phenolic compounds
    Mice vohf project
    Increases
    Improves
    Humans
    Hdl
    Expression
    Efflux
    Consumption
    Antioxidant
    Pharmacology & pharmacy
    Medicine, research & experimental
    Medicine (miscellaneous)
    General biochemistry,genetics and molecular biology
    Ciencias sociales
    Biochemistry, genetics and molecular biology (miscellaneous)
    Biochemistry, genetics and molecular biology (all)
    Biochemistry & molecular biology
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