Autor según el artículo: Cedo, Lidia; Fernandez-Castillejo, Sara; Rubio, Laura; Metso, Jari; Santos, David; Munoz-Aguayo, Daniel; Rivas-Urbina, Andrea; Tondo, Mireia; Mendez-Lara, Karen Alejandra; Farras, Marta; Jauhiainen, Matti; Motilva, Maria-Jose; Fito, Montserrat; Blanco-Vaca, Francisco; Sola, Rosa; Escola-Gil, Joan Carles;
Departamento: Medicina i Cirurgia
Autor/es de la URV: FERNÁNDEZ CASTILLEJO, SARA / Solà Alberich, Rosa Maria
Palabras clave: Virgin olive oil Risk-factors Reverse cholesterol transport Polyphenols Phenolic compounds Mice vohf project Increases Improves Humans Hdl Expression Efflux Consumption Antioxidant
Resumen: The intake of olive oil (OO) enriched with phenolic compounds (PCs) promotes ex vivo HDL-mediated macrophage cholesterol efflux in humans. We aimed to determine the effects of PC-enriched virgin OO on reverse cholesterol transport (RevCT) from macrophages to feces in vivo. Female C57BL/6 mice were given intragastric doses of refined OO (ROO) and a functional unrefined virgin OO enriched with its own PC (FVOO) for 14 days. Our experiments included two independent groups of mice that received intragastric doses of the phenolic extract (PE) used to prepare the FVOO and the vehicle solution (saline), as control, for 14 days. FVOO intake led to a significant increase in serum HDL cholesterol and its ability to induce macrophage cholesterol efflux in vitro when compared with ROO group. This was concomitant with the enhanced macrophage-derived [H-3]cholesterol transport to feces in vivo. PE intakeper sealso increased HDL cholesterol levels and significantly promoted in vivo macrophage-to-feces RevCT rate when compared with saline group. PE upregulated the expression of the main macrophage transporter involved in macrophage cholesterol efflux, theATP binding cassettea1. Our data provide direct evidence of the crucial role of OO PCs in the induction of macrophage-specific RevCT in vivo.
Áreas temáticas: Pharmacology & pharmacy Medicine, research & experimental Medicine (miscellaneous) General biochemistry,genetics and molecular biology Ciencias sociales Biochemistry, genetics and molecular biology (miscellaneous) Biochemistry, genetics and molecular biology (all) Biochemistry & molecular biology
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: rosa.sola@urv.cat
Identificador del autor: 0000-0002-8359-235X
Fecha de alta del registro: 2023-04-02
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: https://www.mdpi.com/2227-9059/8/8/266
Referencia al articulo segun fuente origial: Biomedicines. 8 (8):
Referencia de l'ítem segons les normes APA: Cedo, Lidia; Fernandez-Castillejo, Sara; Rubio, Laura; Metso, Jari; Santos, David; Munoz-Aguayo, Daniel; Rivas-Urbina, Andrea; Tondo, Mireia; Mendez-L (2020). Phenol-Enriched Virgin Olive Oil Promotes Macrophage-Specific Reverse Cholesterol Transport In Vivo. Biomedicines, 8(8), -. DOI: 10.3390/biomedicines8080266
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
DOI del artículo: 10.3390/biomedicines8080266
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2020
Tipo de publicación: Journal Publications