Articles producció científica> Bioquímica i Biotecnologia

High plasma glutamate and a low glutamine-to-glutamate ratio are associated with increased risk of heart Failure but Not Atrial Fibrillation in the Prevención con Dieta Mediterránea (PREDIMED) Study

  • Dades identificatives

    Identificador: imarina:9138900
    Handle: https://hdl.handle.net/20.500.11797/imarina9138900
    Autors:
    Papandreou, ChristopherHernandez-Alonso, PabloBullo, MonicaRuiz-Canela, MiguelLi, JunGuasch-Ferre, MartaToledo, EstefaniaClish, ClaryCorella, DoloresEstruch, RamonCofan, MontserratFito, MontserratRazquin, CristinaAros, FernandoFiol, MiquelSantos-Lozano, Jose MSerra-Majem, LluisLiang, LimingMartinez-Gonzalez, Miguel AHu, Frank BSalas-Salvado, Jordi
    Resum:
    © 2020 The Author(s). Published by Oxford University Press on behalf of the American Society for Nutrition. Background: Although the association between glutamate and glutamine in relation to cardiometabolic disorders has been evaluated, the role of these metabolites in the development of atrial fibrillation (AF) and heart failure (HF) remains unknown. Objectives: We examined associations of glutamate, glutamine, and the glutamine-to-glutamate ratio with AF and HF incidence in a Mediterranean population at high cardiovascular disease (CVD) risk. Methods: The present study used 2 nested case-control studies within the PREDIMED (Prevención con Dieta Mediterránea) study. During ∼10 y of follow-up, there were 509 AF incident cases matched to 618 controls and 326 HF incident cases matched to 426 controls. Plasma concentrations of glutamate and glutamine were semiquantitatively profiled with LC-tandem MS. ORs were estimated with multivariable conditional logistic regression models. Results: In fully adjusted models, per 1-SD increment, glutamate was associated with a 29% (95% CI: 1.08, 1.54) increased risk of HF and glutamine-to-glutamate ratio with a 20% (95% CI: 0.67, 0.94) decreased risk. Glutamine-to-glutamate ratio was also inversely associated with HF risk (OR per 1-SD increment: 0.80; 95% CI: 0.67, 0.94) when comparing extreme quartiles. Higher glutamate concentrations were associated with a worse cardiometabolic risk profile, whereas a higher glutamine-to-glutamate ratio was associated with a better cardiometabolic risk profile. No associations between the concentrations of these metabolites and AF were observed. Conclusions: Our findings suggest that high plasma glutamate concentrations possibly resulting from alterations in the glutamate-glutamine cycle may contribu

  • Altres:

    Autor segons l'article: Papandreou, Christopher; Hernandez-Alonso, Pablo; Bullo, Monica; Ruiz-Canela, Miguel; Li, Jun; Guasch-Ferre, Marta; Toledo, Estefania; Clish, Clary; Corella, Dolores; Estruch, Ramon; Cofan, Montserrat; Fito, Montserrat; Razquin, Cristina; Aros, Fernando; Fiol, Miquel; Santos-Lozano, Jose M; Serra-Majem, Lluis; Liang, Liming; Martinez-Gonzalez, Miguel A; Hu, Frank B; Salas-Salvado, Jordi
    Departament: Bioquímica i Biotecnologia
    Autor/s de la URV: Bulló Bonet, Mònica / Salas Salvadó, Jorge
    Paraules clau: Predimed Heart failure Glutamine Glutamate Atrial fibrillation
    Resum: © 2020 The Author(s). Published by Oxford University Press on behalf of the American Society for Nutrition. Background: Although the association between glutamate and glutamine in relation to cardiometabolic disorders has been evaluated, the role of these metabolites in the development of atrial fibrillation (AF) and heart failure (HF) remains unknown. Objectives: We examined associations of glutamate, glutamine, and the glutamine-to-glutamate ratio with AF and HF incidence in a Mediterranean population at high cardiovascular disease (CVD) risk. Methods: The present study used 2 nested case-control studies within the PREDIMED (Prevención con Dieta Mediterránea) study. During ∼10 y of follow-up, there were 509 AF incident cases matched to 618 controls and 326 HF incident cases matched to 426 controls. Plasma concentrations of glutamate and glutamine were semiquantitatively profiled with LC-tandem MS. ORs were estimated with multivariable conditional logistic regression models. Results: In fully adjusted models, per 1-SD increment, glutamate was associated with a 29% (95% CI: 1.08, 1.54) increased risk of HF and glutamine-to-glutamate ratio with a 20% (95% CI: 0.67, 0.94) decreased risk. Glutamine-to-glutamate ratio was also inversely associated with HF risk (OR per 1-SD increment: 0.80; 95% CI: 0.67, 0.94) when comparing extreme quartiles. Higher glutamate concentrations were associated with a worse cardiometabolic risk profile, whereas a higher glutamine-to-glutamate ratio was associated with a better cardiometabolic risk profile. No associations between the concentrations of these metabolites and AF were observed. Conclusions: Our findings suggest that high plasma glutamate concentrations possibly resulting from alterations in the glutamate-glutamine cycle may contribute to the development of HF in Mediterranean individuals at high CVD risk. This trial was registered at www.isrctn.com as ISRCTN35739639.
    Àrees temàtiques: Serviço social Saúde coletiva Odontología Nutrition and dietetics Nutrition & dietetics Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina ii Medicina i Interdisciplinar General medicine Farmacia Ensino Engenharias ii Enfermagem Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciência de alimentos
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    Adreça de correu electrònic de l'autor: monica.bullo@urv.cat jordi.salas@urv.cat
    Identificador de l'autor: 0000-0002-0218-7046 0000-0003-2700-7459
    Data d'alta del registre: 2024-10-12
    Versió de l'article dipositat: info:eu-repo/semantics/acceptedVersion
    Enllaç font original: https://academic.oup.com/jn/article/150/11/2882/5906638
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referència a l'article segons font original: Journal Of Nutrition. 150 (11): 2882-2889
    Referència de l'ítem segons les normes APA: Papandreou, Christopher; Hernandez-Alonso, Pablo; Bullo, Monica; Ruiz-Canela, Miguel; Li, Jun; Guasch-Ferre, Marta; Toledo, Estefania; Clish, Clary; C (2020). High plasma glutamate and a low glutamine-to-glutamate ratio are associated with increased risk of heart Failure but Not Atrial Fibrillation in the Prevención con Dieta Mediterránea (PREDIMED) Study. Journal Of Nutrition, 150(11), 2882-2889. DOI: 10.1093/jn/nxaa273
    DOI de l'article: 10.1093/jn/nxaa273
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2020
    Tipus de publicació: Journal Publications

  • Paraules clau:

    Medicine (Miscellaneous),Nutrition & Dietetics,Nutrition and Dietetics
    Predimed
    Heart failure
    Glutamine
    Glutamate
    Atrial fibrillation
    Serviço social
    Saúde coletiva
    Odontología
    Nutrition and dietetics
    Nutrition & dietetics
    Nutrição
    Medicine (miscellaneous)
    Medicina veterinaria
    Medicina ii
    Medicina i
    Interdisciplinar
    General medicine
    Farmacia
    Ensino
    Engenharias ii
    Enfermagem
    Educação física
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciência de alimentos

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