Rh-Catalyzed asymmetric hydroaminomethylation of α-Substituted acrylamides: Application in the synthesis of RWAY

Identificador:  imarina:9138904

Handle: https://hdl.handle.net/20.500.11797/imarina9138904

Autors:  Miró, R; Cunillera, A; Margalef, J; Lutz, D; Börner, A; Pamiès, O; Diéguez, M; Godard, C

Resum:
© 2020 American Chemical Society The successful rhodium-catalyzed asymmetric hydroformylation and hydroaminomethylation of α-substituted acrylamides is described using 1,3-phosphite-phosphoramidite ligands based on a sugar backbone. A broad scope of chiral aldehydes and amines were afforded in high yields and excellent enantioselectivities (up to 99%). Furthermore, the synthetic potential of this method is demonstrated by the single-step synthesis of the brain imaging molecule RWAY.