Articles producció científica> Química Física i Inorgànica

Rh-Catalyzed asymmetric hydroaminomethylation of α-Substituted acrylamides: Application in the synthesis of RWAY

  • Dades identificatives

    Identificador: imarina:9138904
    Handle: https://hdl.handle.net/20.500.11797/imarina9138904
    Autors:
    Miró RCunillera AMargalef JLutz DBörner APamies ODiéguez MGodard C
    Resum:
    © 2020 American Chemical Society The successful rhodium-catalyzed asymmetric hydroformylation and hydroaminomethylation of α-substituted acrylamides is described using 1,3-phosphite-phosphoramidite ligands based on a sugar backbone. A broad scope of chiral aldehydes and amines were afforded in high yields and excellent enantioselectivities (up to 99%). Furthermore, the synthetic potential of this method is demonstrated by the single-step synthesis of the brain imaging molecule RWAY.

  • Altres:

    Autor segons l'article: Miró R; Cunillera A; Margalef J; Lutz D; Börner A; Pamies O; Diéguez M; Godard C
    Departament: Química Física i Inorgànica
    e-ISSN: 1523-7052
    Autor/s de la URV: Diéguez Fernández, Montserrat / Godard, Cyril / Pamies Ollé, Oscar
    Codi de projecte: CTQ2016-75016-R
    Resum: © 2020 American Chemical Society The successful rhodium-catalyzed asymmetric hydroformylation and hydroaminomethylation of α-substituted acrylamides is described using 1,3-phosphite-phosphoramidite ligands based on a sugar backbone. A broad scope of chiral aldehydes and amines were afforded in high yields and excellent enantioselectivities (up to 99%). Furthermore, the synthetic potential of this method is demonstrated by the single-step synthesis of the brain imaging molecule RWAY.
    Àrees temàtiques: Química Physical and theoretical chemistry Organic chemistry Medicina ii Medicina i Materiais Interdisciplinar General medicine Farmacia Ciências biológicas ii Ciências biológicas i Ciências agrárias i Chemistry, organic Biotecnología Biodiversidade Biochemistry
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 1523-7060
    Adreça de correu electrònic de l'autor: montserrat.dieguez@urv.cat oscar.pamies@urv.cat cyril.godard@urv.cat
    Identificador de l'autor: 0000-0002-8450-0656 0000-0002-2352-8508 0000-0001-5762-4904
    Data d'alta del registre: 2023-02-19
    Versió de l'article dipositat: info:eu-repo/semantics/acceptedVersion
    Enllaç font original: https://pubs.acs.org/doi/10.1021/acs.orglett.0c03433
    Programa de finançament: PROGRAMA ESTATAL DE INVESTIGACIÓN, DESARROLLO E INNOVACIÓN ORIENTADA A LOS RETOS DE LA SOCIEDAD
    Referència a l'article segons font original: Organic Letters. 22 (22): 9036-9040
    Referència de l'ítem segons les normes APA: Miró R; Cunillera A; Margalef J; Lutz D; Börner A; Pamies O; Diéguez M; Godard C (2020). Rh-Catalyzed asymmetric hydroaminomethylation of α-Substituted acrylamides: Application in the synthesis of RWAY. Organic Letters, 22(22), 9036-9040. DOI: 10.1021/acs.orglett.0c03433
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    Acrònim: ECO2VALCAT
    DOI de l'article: 10.1021/acs.orglett.0c03433
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2020
    Acció del programa de finançament: VALORIZACION EFICIENTE DE CO2 A COMBUSTIBLES Y COMPUESTOS DE ALTO VALOR AÑADIDO MEDIANTE CATALISIS HOMOGENEA Y NANO-CATALISIS
    Tipus de publicació: Journal Publications

  • Paraules clau:

    Biochemistry,Chemistry, Organic,Organic Chemistry,Physical and Theoretical Chemistry
    Química
    Physical and theoretical chemistry
    Organic chemistry
    Medicina ii
    Medicina i
    Materiais
    Interdisciplinar
    General medicine
    Farmacia
    Ciências biológicas ii
    Ciências biológicas i
    Ciências agrárias i
    Chemistry, organic
    Biotecnología
    Biodiversidade
    Biochemistry

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