Articles producció científicaQuímica Física i Inorgànica

Rh-Catalyzed asymmetric hydroaminomethylation of α-Substituted acrylamides: Application in the synthesis of RWAY

  • Identification data

    Identifier:  imarina:9138904
    Handle: https://hdl.handle.net/20.500.11797/imarina9138904
    Authors:  Miro, Roger; Cunillera, Anton; Margalef, Jessica; Lutz, Domke; Boerner, Armin; Pamies, Oscar; Dieguez, Montserrat; Godard, Cyril
    Abstract:
    © 2020 American Chemical Society The successful rhodium-catalyzed asymmetric hydroformylation and hydroaminomethylation of α-substituted acrylamides is described using 1,3-phosphite-phosphoramidite ligands based on a sugar backbone. A broad scope of chiral aldehydes and amines were afforded in high yields and excellent enantioselectivities (up to 99%). Furthermore, the synthetic potential of this method is demonstrated by the single-step synthesis of the brain imaging molecule RWAY.

  • Others:

    Link to the original source: https://pubs.acs.org/doi/10.1021/acs.orglett.0c03433
    Funding program action: VALORIZACION EFICIENTE DE CO2 A COMBUSTIBLES Y COMPUESTOS DE ALTO VALOR AÑADIDO MEDIANTE CATALISIS HOMOGENEA Y NANO-CATALISIS
    APA: Miro, Roger; Cunillera, Anton; Margalef, Jessica; Lutz, Domke; Boerner, Armin; Pamies, Oscar; Dieguez, Montserrat; Godard, Cyril (2020). Rh-Catalyzed asymmetric hydroaminomethylation of α-Substituted acrylamides: Application in the synthesis of RWAY. Organic Letters, 22(22), 9036-9040. DOI: 10.1021/acs.orglett.0c03433
    Paper original source: Organic Letters. 22 (22): 9036-9040
    Article's DOI: 10.1021/acs.orglett.0c03433
    Funding program: PROGRAMA ESTATAL DE INVESTIGACIÓN, DESARROLLO E INNOVACIÓN ORIENTADA A LOS RETOS DE LA SOCIEDAD
    Journal publication year: 2020
    Entity: Universitat Rovira i Virgili
    Paper version: info:eu-repo/semantics/acceptedVersion
    Record's date: 2025-01-28
    URV's Author/s: CUNILLERA MARTIN, ANTON / Diéguez Fernández, Montserrat / Godard, Cyril / MARGALEF LLEBARIA, JOAQUIM / Miró Serra, Roger / Pamies Ollé, Oscar
    Department: Química Física i Inorgànica
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Acronym: ECO2VALCAT
    Publication Type: Journal Publications
    ISSN: 1523-7060
    Author, as appears in the article.: Miro, Roger; Cunillera, Anton; Margalef, Jessica; Lutz, Domke; Boerner, Armin; Pamies, Oscar; Dieguez, Montserrat; Godard, Cyril
    Project code: CTQ2016-75016-R
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    e-ISSN: 1523-7052
    Thematic Areas: Química, Physical and theoretical chemistry, Organic chemistry, Medicina ii, Medicina i, Materiais, Interdisciplinar, General medicine, Farmacia, Ciências biológicas ii, Ciências biológicas i, Ciências agrárias i, Chemistry, organic, Biotecnología, Biodiversidade, Biochemistry
    Author's mail: roger.miros@estudiants.urv.cat, cyril.godard@urv.cat, oscar.pamies@urv.cat, montserrat.dieguez@urv.cat

  • Keywords:

    Clean water and sanitation
    Biochemistry
    Chemistry
    Organic
    Organic Chemistry
    Physical and Theoretical Chemistry
    Química
    Medicina ii
    Medicina i
    Materiais
    Interdisciplinar
    General medicine
    Farmacia
    Ciências biológicas ii
    Ciências biológicas i
    Ciências agrárias i
    Biotecnología
    Biodiversidade

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