Articles producció científicaQuímica Física i Inorgànica

Rh-Catalyzed asymmetric hydroaminomethylation of α-Substituted acrylamides: Application in the synthesis of RWAY

  • Identification data

    Identifier:  imarina:9138904
    Handle: https://hdl.handle.net/20.500.11797/imarina9138904
    Authors:  Miró, R; Cunillera, A; Margalef, J; Lutz, D; Börner, A; Pamiès, O; Diéguez, M; Godard, C
    Abstract:
    © 2020 American Chemical Society The successful rhodium-catalyzed asymmetric hydroformylation and hydroaminomethylation of α-substituted acrylamides is described using 1,3-phosphite-phosphoramidite ligands based on a sugar backbone. A broad scope of chiral aldehydes and amines were afforded in high yields and excellent enantioselectivities (up to 99%). Furthermore, the synthetic potential of this method is demonstrated by the single-step synthesis of the brain imaging molecule RWAY.

  • Others:

    Link to the original source: https://pubs.acs.org/doi/10.1021/acs.orglett.0c03433
    Funding program action: VALORIZACION EFICIENTE DE CO2 A COMBUSTIBLES Y COMPUESTOS DE ALTO VALOR AÑADIDO MEDIANTE CATALISIS HOMOGENEA Y NANO-CATALISIS
    APA: Miró, R; Cunillera, A; Margalef, J; Lutz, D; Börner, A; Pamiès, O; Diéguez, M; Godard, C (2020). Rh-Catalyzed asymmetric hydroaminomethylation of α-Substituted acrylamides: Application in the synthesis of RWAY. ORGANIC LETTERS, 22(22), 9036-9040. DOI: 10.1021/acs.orglett.0c03433
    Paper original source: ORGANIC LETTERS. 22 (22): 9036-9040
    Article's DOI: 10.1021/acs.orglett.0c03433
    Funding program: PROGRAMA ESTATAL DE INVESTIGACIÓN, DESARROLLO E INNOVACIÓN ORIENTADA A LOS RETOS DE LA SOCIEDAD
    Journal publication year: 2020-11-20
    Entity: Universitat Rovira i Virgili
    Paper version: info:eu-repo/semantics/acceptedVersion
    Record's date: 2026-05-09
    URV's Author/s: CUNILLERA MARTIN, ANTON / Diéguez Fernández, Montserrat / Godard, Cyril / MARGALEF LLEBARIA, JOAQUIM / Miró Serra, Roger / Pamies Ollé, Oscar
    Department: Química Física i Inorgànica
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Acronym: ECO2VALCAT
    Publication Type: Journal Publications
    ISSN: 1523-7060
    Author, as appears in the article.: Miró, R; Cunillera, A; Margalef, J; Lutz, D; Börner, A; Pamiès, O; Diéguez, M; Godard, C
    Project code: CTQ2016-75016-R
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    e-ISSN: 1523-7052
    Thematic Areas: Physical and theoretical chemistry, Organic chemistry, General medicine, Chemistry, organic, Biotecnología, Biodiversidade, Biochemistry
    Author's mail: roger.miros@estudiants.urv.cat, roger.miros@estudiants.urv.cat, roger.miros@estudiants.urv.cat, cyril.godard@urv.cat, cyril.godard@urv.cat, oscar.pamies@urv.cat, oscar.pamies@urv.cat, montserrat.dieguez@urv.cat, montserrat.dieguez@urv.cat

  • Keywords:

    Clean water and sanitation
    Biochemistry
    Chemistry
    Organic
    Organic Chemistry
    Physical and Theoretical Chemistry
    General medicine
    Biotecnología
    Biodiversidade

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