Author, as appears in the article.: Miró R; Cunillera A; Margalef J; Lutz D; Börner A; Pamies O; Diéguez M; Godard C

Department: Química Física i Inorgànica

e-ISSN: 1523-7052

URV's Author/s: Diéguez Fernández, Montserrat / Godard, Cyril / Pamies Ollé, Oscar

Project code: CTQ2016-75016-R

Abstract: © 2020 American Chemical Society The successful rhodium-catalyzed asymmetric hydroformylation and hydroaminomethylation of α-substituted acrylamides is described using 1,3-phosphite-phosphoramidite ligands based on a sugar backbone. A broad scope of chiral aldehydes and amines were afforded in high yields and excellent enantioselectivities (up to 99%). Furthermore, the synthetic potential of this method is demonstrated by the single-step synthesis of the brain imaging molecule RWAY.

Thematic Areas: Química Physical and theoretical chemistry Organic chemistry Medicina ii Medicina i Materiais Interdisciplinar General medicine Farmacia Ciências biológicas ii Ciências biológicas i Ciências agrárias i Chemistry, organic Biotecnología Biodiversidade Biochemistry

licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 1523-7060

Author's mail: montserrat.dieguez@urv.cat oscar.pamies@urv.cat cyril.godard@urv.cat

Author identifier: 0000-0002-8450-0656 0000-0002-2352-8508 0000-0001-5762-4904

Record's date: 2023-02-19

Papper version: info:eu-repo/semantics/acceptedVersion

Link to the original source: https://pubs.acs.org/doi/10.1021/acs.orglett.0c03433

Funding program: PROGRAMA ESTATAL DE INVESTIGACIÓN, DESARROLLO E INNOVACIÓN ORIENTADA A LOS RETOS DE LA SOCIEDAD

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Organic Letters. 22 (22): 9036-9040

APA: Miró R; Cunillera A; Margalef J; Lutz D; Börner A; Pamies O; Diéguez M; Godard C (2020). Rh-Catalyzed asymmetric hydroaminomethylation of α-Substituted acrylamides: Application in the synthesis of RWAY. Organic Letters, 22(22), 9036-9040. DOI: 10.1021/acs.orglett.0c03433

Acronym: ECO2VALCAT

Article's DOI: 10.1021/acs.orglett.0c03433

Entity: Universitat Rovira i Virgili

Journal publication year: 2020

Funding program action: VALORIZACION EFICIENTE DE CO2 A COMBUSTIBLES Y COMPUESTOS DE ALTO VALOR AÑADIDO MEDIANTE CATALISIS HOMOGENEA Y NANO-CATALISIS

Publication Type: Journal Publications