Autor segons l'article: Reig-Vano, B; Tylkowski, B; Montané, X; Giamberini, M
Departament: Enginyeria Química Química Analítica i Química Orgànica
Autor/s de la URV: Giamberini, Marta / Montané Montané, Xavier / Reig Vañó, Belén / Tylkowski, Bartosz
Paraules clau: Tissue engineering Protein delivery Neoplasms Hydrogels Humans Drug delivery systems Drug delivery Chemotherapy Cell encapsulation Capsules Cancer Biocompatible materials Animals Alginates Alginate 3-d scaffold
Resum: © 2020 Cancer is a major health issue concerning to all of us. Current treatment options are still limited due to not-selective action. Encapsulation is contemplated as an innovative approach to address systemic toxicity and tumor resistance caused by traditional therapies, while increasing encapsulated compounds bioavailability. The coating material of capsules strongly determines the success of the system. Since alginate has been proved non-toxic, biocompatible and biodegradable, it is considered a potential vehicle for therapeutic factors encapsulation. Besides, it has the particular ability to form hydrogels, which hold a high-water content and greatly resemble to natural soft tissues. The present review exposes the state-of-the-art and the most sophisticated alginate-based systems for cancer therapy and research. It begins with an overview of alginate hydrogels and the qualities that make them especially suitable for biomedical applications. In the following section, the application of alginate hydrogels as pioneering strategies for cancer treatment is described. Several examples of alginate-based delivery systems of therapeutic drugs, proteins and nucleic acids are provided. Significant emphasis is placed in both oral delivery systems and colorectal cancer therapy. Moreover, the role of alginate 3-D scaffolds for both cell culture and delivery is explained. Lastly, other applications of alginate-based hydrogels such as tumor biomarkers immunosensing and fluorescent surgical marker are included.
Àrees temàtiques: Zootecnia / recursos pesqueiros Structural biology Química Polymer science Planejamento urbano e regional / demografia Odontología Nutrição Molecular biology Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Geociências General energy Farmacia Ensino Engenharias iv Engenharias iii Engenharias ii Engenharias i Energy (miscellaneous) Economics and econometrics Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Chemistry, applied Biotecnología Biodiversidade Biochemistry & molecular biology Biochemistry Astronomia / física
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 0141-8130
Adreça de correu electrònic de l'autor: xavier.montane@urv.cat bartosz.tylkowski@urv.cat marta.giamberini@urv.cat belen.reig@estudiants.urv.cat belen.reig@estudiants.urv.cat
Identificador de l'autor: 0000-0002-1426-239X 0000-0002-4163-0178 0000-0001-8278-3552 0000-0001-6402-4499 0000-0001-6402-4499
Data d'alta del registre: 2024-06-28
Versió de l'article dipositat: info:eu-repo/semantics/acceptedVersion
Enllaç font original: https://www.sciencedirect.com/science/article/abs/pii/S0141813020353356
URL Document de llicència: http://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: International Journal Of Biological Macromolecules. 170 424-436
Referència de l'ítem segons les normes APA: Reig-Vano, B; Tylkowski, B; Montané, X; Giamberini, M (2021). Alginate-based hydrogels for cancer therapy and research. International Journal Of Biological Macromolecules, 170(), 424-436. DOI: 10.1016/j.ijbiomac.2020.12.161
DOI de l'article: 10.1016/j.ijbiomac.2020.12.161
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2021
Tipus de publicació: Journal Publications
Repositori URV