Autor según el artículo: Reig-Vano, B; Tylkowski, B; Montané, X; Giamberini, M
Departamento: Enginyeria Química Química Analítica i Química Orgànica
Autor/es de la URV: Giamberini, Marta / Montané Montané, Xavier / Reig Vañó, Belén / Tylkowski, Bartosz
Palabras clave: Tissue engineering Protein delivery Neoplasms Hydrogels Humans Drug delivery systems Drug delivery Chemotherapy Cell encapsulation Capsules Cancer Biocompatible materials Animals Alginates Alginate 3-d scaffold
Resumen: © 2020 Cancer is a major health issue concerning to all of us. Current treatment options are still limited due to not-selective action. Encapsulation is contemplated as an innovative approach to address systemic toxicity and tumor resistance caused by traditional therapies, while increasing encapsulated compounds bioavailability. The coating material of capsules strongly determines the success of the system. Since alginate has been proved non-toxic, biocompatible and biodegradable, it is considered a potential vehicle for therapeutic factors encapsulation. Besides, it has the particular ability to form hydrogels, which hold a high-water content and greatly resemble to natural soft tissues. The present review exposes the state-of-the-art and the most sophisticated alginate-based systems for cancer therapy and research. It begins with an overview of alginate hydrogels and the qualities that make them especially suitable for biomedical applications. In the following section, the application of alginate hydrogels as pioneering strategies for cancer treatment is described. Several examples of alginate-based delivery systems of therapeutic drugs, proteins and nucleic acids are provided. Significant emphasis is placed in both oral delivery systems and colorectal cancer therapy. Moreover, the role of alginate 3-D scaffolds for both cell culture and delivery is explained. Lastly, other applications of alginate-based hydrogels such as tumor biomarkers immunosensing and fluorescent surgical marker are included.
Áreas temáticas: Zootecnia / recursos pesqueiros Structural biology Química Polymer science Planejamento urbano e regional / demografia Odontología Nutrição Molecular biology Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Geociências General energy Food science Farmacia Ensino Engenharias iv Engenharias iii Engenharias ii Engenharias i Energy (miscellaneous) Economics and econometrics Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Chemistry, applied Biotecnología Biomaterials Biodiversidade Biochemistry & molecular biology Biochemistry Astronomia / física
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 0141-8130
Direcció de correo del autor: xavier.montane@urv.cat belen.reig@estudiants.urv.cat belen.reig@estudiants.urv.cat marta.giamberini@urv.cat bartosz.tylkowski@urv.cat
Identificador del autor: 0000-0002-1426-239X 0000-0001-6402-4499 0000-0001-6402-4499 0000-0001-8278-3552 0000-0002-4163-0178
Fecha de alta del registro: 2024-07-27
Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion
Enlace a la fuente original: https://www.sciencedirect.com/science/article/abs/pii/S0141813020353356
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: International Journal Of Biological Macromolecules. 170 424-436
Referencia de l'ítem segons les normes APA: Reig-Vano, B; Tylkowski, B; Montané, X; Giamberini, M (2021). Alginate-based hydrogels for cancer therapy and research. International Journal Of Biological Macromolecules, 170(), 424-436. DOI: 10.1016/j.ijbiomac.2020.12.161
DOI del artículo: 10.1016/j.ijbiomac.2020.12.161
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2021
Tipo de publicación: Journal Publications