Articles producció científica> Química Analítica i Química Orgànica

Alginate-based hydrogels for cancer therapy and research

  • Datos identificativos

    Identificador: imarina:9139046
    Autores:
    Reig-Vano, BTylkowski, BMontané, XGiamberini, M
    Resumen:
    © 2020 Cancer is a major health issue concerning to all of us. Current treatment options are still limited due to not-selective action. Encapsulation is contemplated as an innovative approach to address systemic toxicity and tumor resistance caused by traditional therapies, while increasing encapsulated compounds bioavailability. The coating material of capsules strongly determines the success of the system. Since alginate has been proved non-toxic, biocompatible and biodegradable, it is considered a potential vehicle for therapeutic factors encapsulation. Besides, it has the particular ability to form hydrogels, which hold a high-water content and greatly resemble to natural soft tissues. The present review exposes the state-of-the-art and the most sophisticated alginate-based systems for cancer therapy and research. It begins with an overview of alginate hydrogels and the qualities that make them especially suitable for biomedical applications. In the following section, the application of alginate hydrogels as pioneering strategies for cancer treatment is described. Several examples of alginate-based delivery systems of therapeutic drugs, proteins and nucleic acids are provided. Significant emphasis is placed in both oral delivery systems and colorectal cancer therapy. Moreover, the role of alginate 3-D scaffolds for both cell culture and delivery is explained. Lastly, other applications of alginate-based hydrogels such as tumor biomarkers immunosensing and fluorescent surgical marker are included.
  • Otros:

    Autor según el artículo: Reig-Vano, B; Tylkowski, B; Montané, X; Giamberini, M
    Departamento: Enginyeria Química Química Analítica i Química Orgànica
    Autor/es de la URV: Giamberini, Marta / Montané Montané, Xavier / Reig Vañó, Belén / Tylkowski, Bartosz
    Palabras clave: Tissue engineering Protein delivery Neoplasms Hydrogels Humans Drug delivery systems Drug delivery Chemotherapy Cell encapsulation Capsules Cancer Biocompatible materials Animals Alginates Alginate 3-d scaffold
    Resumen: © 2020 Cancer is a major health issue concerning to all of us. Current treatment options are still limited due to not-selective action. Encapsulation is contemplated as an innovative approach to address systemic toxicity and tumor resistance caused by traditional therapies, while increasing encapsulated compounds bioavailability. The coating material of capsules strongly determines the success of the system. Since alginate has been proved non-toxic, biocompatible and biodegradable, it is considered a potential vehicle for therapeutic factors encapsulation. Besides, it has the particular ability to form hydrogels, which hold a high-water content and greatly resemble to natural soft tissues. The present review exposes the state-of-the-art and the most sophisticated alginate-based systems for cancer therapy and research. It begins with an overview of alginate hydrogels and the qualities that make them especially suitable for biomedical applications. In the following section, the application of alginate hydrogels as pioneering strategies for cancer treatment is described. Several examples of alginate-based delivery systems of therapeutic drugs, proteins and nucleic acids are provided. Significant emphasis is placed in both oral delivery systems and colorectal cancer therapy. Moreover, the role of alginate 3-D scaffolds for both cell culture and delivery is explained. Lastly, other applications of alginate-based hydrogels such as tumor biomarkers immunosensing and fluorescent surgical marker are included.
    Áreas temáticas: Zootecnia / recursos pesqueiros Structural biology Química Polymer science Planejamento urbano e regional / demografia Odontología Nutrição Molecular biology Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Geociências General energy Food science Farmacia Ensino Engenharias iv Engenharias iii Engenharias ii Engenharias i Energy (miscellaneous) Economics and econometrics Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Chemistry, applied Biotecnología Biomaterials Biodiversidade Biochemistry & molecular biology Biochemistry Astronomia / física
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 0141-8130
    Direcció de correo del autor: xavier.montane@urv.cat belen.reig@estudiants.urv.cat belen.reig@estudiants.urv.cat marta.giamberini@urv.cat bartosz.tylkowski@urv.cat
    Identificador del autor: 0000-0002-1426-239X 0000-0001-6402-4499 0000-0001-6402-4499 0000-0001-8278-3552 0000-0002-4163-0178
    Fecha de alta del registro: 2024-07-27
    Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion
    Enlace a la fuente original: https://www.sciencedirect.com/science/article/abs/pii/S0141813020353356
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referencia al articulo segun fuente origial: International Journal Of Biological Macromolecules. 170 424-436
    Referencia de l'ítem segons les normes APA: Reig-Vano, B; Tylkowski, B; Montané, X; Giamberini, M (2021). Alginate-based hydrogels for cancer therapy and research. International Journal Of Biological Macromolecules, 170(), 424-436. DOI: 10.1016/j.ijbiomac.2020.12.161
    DOI del artículo: 10.1016/j.ijbiomac.2020.12.161
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2021
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Biochemistry,Biochemistry & Molecular Biology,Chemistry, Applied,Economics and Econometrics,Energy (Miscellaneous),Medicine (Miscellaneous),Molecular Biology,Polymer Science,Structural Biology
    Tissue engineering
    Protein delivery
    Neoplasms
    Hydrogels
    Humans
    Drug delivery systems
    Drug delivery
    Chemotherapy
    Cell encapsulation
    Capsules
    Cancer
    Biocompatible materials
    Animals
    Alginates
    Alginate
    3-d scaffold
    Zootecnia / recursos pesqueiros
    Structural biology
    Química
    Polymer science
    Planejamento urbano e regional / demografia
    Odontología
    Nutrição
    Molecular biology
    Medicine (miscellaneous)
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Materiais
    Interdisciplinar
    Geociências
    General energy
    Food science
    Farmacia
    Ensino
    Engenharias iv
    Engenharias iii
    Engenharias ii
    Engenharias i
    Energy (miscellaneous)
    Economics and econometrics
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência de alimentos
    Chemistry, applied
    Biotecnología
    Biomaterials
    Biodiversidade
    Biochemistry & molecular biology
    Biochemistry
    Astronomia / física
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