Iron status in mid-pregnancy and associations with interpregnancy interval

Identificador:  imarina:9156122

Handle: https://hdl.handle.net/20.500.11797/imarina9156122

Autors:  Caspersen, Ida Henriette; Iglesias-Vazquez, Lucia; Abel, Marianne Hope; Brantsaeter, Anne Lise; Arija, Victoria; Erlund, Iris; Meltzer, Helle Margrete

Resum:
© The Authors 2021. Adequate iron supply in pregnancy is important for both the woman and the foetus, but iron status is often assessed late in first trimester, if assessed at all. Therefore, identification of factors associated with iron status is important to target vulnerable groups with increased risk of deficiency. Our objectives were to 1) describe iron status in mid-pregnancy and 2) identify sociodemographic and lifestyle predictors of pregnancy iron status. This cross-sectional study uses data from The Norwegian Mother, Father and Child Cohort Study (MoBa, collected 2002-2008) and The Medical Birth Registry of Norway. Iron status was measured as non-fasting plasma ferritin (P-Fe) and transferrin in gestational week 18 (n=2990), and by lowest reported haemoglobin (Hb) in gestational weeks 0-30 (n=39,322). We explored predictors of iron status with elastic net, linear and log-binomial regression models. Median P-Fe was 33 μg/L and 14 % had depleted iron stores (P-Fe <15 μg/L). P-Fe below 30 μg/L was associated with reduced Hb. We identified eleven predictors, with interpregnancy interval (IPI) and parity among the most important. Depleted iron stores was more common among women with IPI <6 months (56%) and 6-11 months (33%) than among those with IPI 24-59 months (19%) and among nulliparous women (5%). Positively associated factors with iron status included hormonal contraceptives, age, BMI, smoking, meat consumption, and multi-supplement use. Our results highlight the importance of ferritin measurements in women of childbearing age, especially among women not using hormonal contraceptives and women with previous and recent childbirths.