Articles producció científica> Medicina i Cirurgia

Low-density lipoprotein from active SLE patients is more atherogenic to endothelial cells than low-density lipoprotein from the same patients during remission

  • Dades identificatives

    Identificador: imarina:9173183
  • Autors:

    Rodríguez-Calvo, R
    Guardiola, M
    Oliva, I
    Arrando, H
    Arranz, I
    Ferré, A
    Pellicer, P
    Parra, S
    Ribalta, J
    Castro, A
  • Altres:

    Autor segons l'article: Rodríguez-Calvo, R; Guardiola, M; Oliva, I; Arrando, H; Arranz, I; Ferré, A; Pellicer, P; Parra, S; Ribalta, J; Castro, A
    Departament: Medicina i Cirurgia
    Autor/s de la URV: Arranz De La Calle, Isabel / Castro Salomó, Antoni / Guardiola Guionnet, Montserrat / Oliva Rodríguez, Iris / Parra Pérez, Sandra / Ribalta Vives, Josep / Rodríguez Calvo, Ricardo
    Paraules clau: Systemic-lupus-erythematosus Sle Low-density lipoprotein Endothelial cells Cardiovascular disease subclasses risk low-density lipoprotein endothelial cells coronary-heart-disease cardiovascular disease accelerated atherosclerosis
    Resum: © The Author(s) 2020. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: journals.permissions@oup.com. OBJECTIVES: SLE patients have an enhanced risk of atherosclerosis and cardiovascular disease. However, the increased prevalence of cardiovascular disease is not fully explained by traditional Framingham cardiovascular risk factors. Specific features of low-density lipoprotein (LDL) particles, other than plasma concentration, may induce accelerated atherosclerosis at early stages in these patients. Thus, we aimed to explore the impact of LDL from both active and inactive SLE patients on human aortic endothelial cells. METHODS: Human aortic endothelial cells were stimulated with the same concentration of LDL particles isolated from pooled serum that was collected from 13 SLE patients during both active and inactive states. Gene expression and cell migration assays were performed. RESULTS: Circulating LDL particles obtained from healthy volunteers and SLE patients in both remission and flare states were comparable in terms of number, cholesterol and triglyceride content, and net electric charge. Stimulation of cells with LDL from active SLE patients induced the expression of vascular cell adhesion molecule 1 (∼2.0-fold, P < 0.05), monocyte chemoattractant protein 1 (∼2.0-fold, P < 0.05) and matrix metallopeptidase 2 (∼1.6-fold, P < 0.01) compared with cells stimulated with LDL from inactive SLE patients. Additionally, LDL extracted from active patients increased cell migration in a wound-healing assay (1.4-fold, P < 0.05). CONCLUSION: Our data show that, at the same LDL concentration, LDL from active SLE patients had increased proatherogenic effects on endothelial cells compared with LDL from the same patients when in an inactive or remission state.
    Àrees temàtiques: Saúde coletiva Rheumatology Pharmacology (medical) Odontología Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Farmacia Ensino Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciência de alimentos Biotecnología
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    Adreça de correu electrònic de l'autor: ricardo.rodriguez@urv.cat isabel.arranz@estudiants.urv.cat sandra.parra@urv.cat antoni.castro@urv.cat montse.guardiola@urv.cat josep.ribalta@urv.cat
    Identificador de l'autor: 0000-0001-9363-6574 0000-0001-5441-6333 0000-0002-9696-7384 0000-0002-8879-4719
    Data d'alta del registre: 2024-07-27
    Versió de l'article dipositat: info:eu-repo/semantics/submittedVersion
    Enllaç font original: https://academic.oup.com/rheumatology/article-abstract/60/2/866/5897208?redirectedFrom=fulltext
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referència a l'article segons font original: Rheumatology. 60 (2): 866-871
    Referència de l'ítem segons les normes APA: Rodríguez-Calvo, R; Guardiola, M; Oliva, I; Arrando, H; Arranz, I; Ferré, A; Pellicer, P; Parra, S; Ribalta, J; Castro, A (2021). Low-density lipoprotein from active SLE patients is more atherogenic to endothelial cells than low-density lipoprotein from the same patients during remission. Rheumatology, 60(2), 866-871. DOI: 10.1093/rheumatology/keaa380
    DOI de l'article: 10.1093/rheumatology/keaa380
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2021
    Tipus de publicació: Journal Publications
  • Paraules clau:

    Pharmacology (Medical),Rheumatology
    Systemic-lupus-erythematosus
    Sle
    Low-density lipoprotein
    Endothelial cells
    Cardiovascular disease
    subclasses
    risk
    low-density lipoprotein
    endothelial cells
    coronary-heart-disease
    cardiovascular disease
    accelerated atherosclerosis
    Saúde coletiva
    Rheumatology
    Pharmacology (medical)
    Odontología
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    General medicine
    Farmacia
    Ensino
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciência de alimentos
    Biotecnología
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