Autor segons l'article: Grau-Bove, Carme; Gines, Iris; Beltran-Debon, Raul; Terra, Ximena; Blay, M Teresa; Pinent, Montserrat; Ardevol, Anna
Departament: Bioquímica i Biotecnologia Medicina i Cirurgia
Autor/s de la URV: Ardévol Grau, Anna / Beltrán Debón, Raúl Alejandro / Blay Olivé, Maria Teresa / GINÉS MIR, IRIS / Grau Bové, Maria Carmen / Pinent Armengol, Montserrat / Terra Barbadora, Ximena
Paraules clau: Rats, wistar Rats Procyanidin Proanthocyanidins Islets of langerhans Insulin/glucagon Insulin Grape seed extract Glucagon-like peptide-1 receptor Glucagon-like peptide 1 Glucagon Glp1 Glp-1 receptor Cafeteria diet Animals
Resum: The endocrine pancreas plays a key role in metabolism. Procyanidins (GSPE) targets β-cells and glucagon-like peptide-1 (GLP-1)-producing cells; however, there is no information on the effects of GSPE on glucagon. We performed GSPE preventive treatments administered to Wistar rats before or at the same time as they were fed a cafeteria diet during 12 or 17 weeks. We then measured the pancreatic function and GLP-1 production. We found that glucagonemia remains modified by GSPE pre-treatment several weeks after the treatment has finished. The animals showed a higher GLP-1 response to glucose stimulation, together with a trend towards a higher GLP-1 receptor expression in the pancreas. When the GSPE treatment was administered every second week, the endocrine pancreas behaved differently. We show here that glucagon is a more sensitive parameter than insulin to GSPE treatments, with a secretion that is highly linked to GLP-1 ileal functionality and dependent on the type of treatment.
Àrees temàtiques: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
Adreça de correu electrònic de l'autor: mariacarmen.grau@urv.cat mariacarmen.grau@urv.cat mariacarmen.grau@urv.cat anna.ardevol@urv.cat ximena.terra@urv.cat mteresa.blay@urv.cat montserrat.pinent@urv.cat raul.beltran@urv.cat
Identificador de l'autor: 0000-0003-0156-7538 0000-0003-1043-5844 0000-0002-6256-9847 0000-0003-3550-5378 0000-0001-9691-1906
Data d'alta del registre: 2024-10-12
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
Enllaç font original: https://www.mdpi.com/2072-6643/13/4/1084
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: Nutrients. 13 (4): 1084-
Referència de l'ítem segons les normes APA: Grau-Bove, Carme; Gines, Iris; Beltran-Debon, Raul; Terra, Ximena; Blay, M Teresa; Pinent, Montserrat; Ardevol, Anna (2021). Glucagon shows higher sensitivity than insulin to grapeseed proanthocyanidin extract (GSPE) treatment in cafeteria-fed rats. Nutrients, 13(4), 1084-. DOI: 10.3390/nu13041084
DOI de l'article: 10.3390/nu13041084
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2021
Tipus de publicació: Journal Publications
Repositori URV