Autor segons l'article: Martinez, Maria Angeles; Gonzalez, Neus; Marti, Anna; Marques, Montse; Rovira, Joaquim; Kumar, Vikas; Nadal, Marti;
Departament: Ciències Mèdiques Bàsiques Enginyeria Química Bioquímica i Biotecnologia
Autor/s de la URV: Gonzalez Paradell, Nieves / Kumar, Vikas / Marquès Bueno, Montserrat / MARTÍ PAPIOL, ANNA / Martí Zaragoza, Àlex / Martínez Rodríguez, María Ángeles / Nadal Lomas, Martí / Rovira Solano, Joaquim
Paraules clau: Variability Urine sampling Urine level Urine concentrations Urine Tolerable daily intake Third trimester pregnancy Spain Second trimester pregnancy Sampling Reconstruction Priority journal Prenatal exposure Pregnant women Pregnant woman Pregnancy Predictors Physiology Phenols Phenol derivative Mothers Measurement accuracy Mass fragmentography Liquid phase microextraction Limit of quantitation Limit of detection Humans Human Health survey Fruit consumption Food First trimester pregnancy Fetal-growth Female Exposure reconstruction Estimation method Eating habit Dietary intake Dietary exposure Data analysis software Creatinine Controlled study Concentration (composition) Cohort analysis Citrus fruit Citrus Canned food Bpa Body weight Bisphenol a Birth-weight Biomonitoring Biological monitoring Biochemistry Benzhydryl derivative Benzhydryl compounds Article Adult 4,4' isopropylidenediphenol
Resum: This study was aimed at reconstructing the exposure to bisphenol (BPA) of 60 pregnant women from the EXHESSpain cohort. A biomonitoring study was conducted by determining BPA levels in urine samples over the three trimesters of pregnancy. Moreover, the correlations between BPA levels and the role of different potential exposure sources, with special emphasis on the dietary intake, were also studied. Urine samples were subjected to dispersive liquid-liquid microextraction and the subsequent analysis via gas chromatography-mass spectrometry. BPA was detected in 76% of the urine samples. A significant decrease of urinary BPA levels was observed along pregnancy, as mean concentrations of creatinine-adjusted BPA were 4.64, 4.84 and 2.51 ?g/g in the first, second and third trimester, respectively. This decrease was essentially associated with changes in the dietary habits of the pregnant women, including a lower intake of canned food and drinks. However, the potential role of other pregnancy-related biochemical or physiological factors should not be disregarded. Very interestingly, significant differences in urine BPA levels were found according to the fruit consumption pattern, as women who ate more citrus fruits showed lower BPA concentrations in urine. The reconstructed exposure to BPA was estimated in 0.072, 0.069 and 0.038 ?g BPA/kg of body weight/day in the first, second and third trimesters, respectively. These values are far below the temporary tolerable daily intake (t-TDI) established by the EFSA.
Àrees temàtiques: Zootecnia / recursos pesqueiros Saúde coletiva Química Public, environmental & occupational health Public health, environmental and occupational health Psicología Planejamento urbano e regional / demografia Odontología Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Geociências General medicine General environmental science Farmacia Environmental sciences Environmental science (miscellaneous) Environmental science (all) Ensino Engenharias iii Engenharias ii Engenharias i Enfermagem Educação física Direito Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Biochemistry Astronomia / física
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
Adreça de correu electrònic de l'autor: vikas.kumar@urv.cat mangeles.martinez@urv.cat anna.marti@urv.cat joaquim.rovira@urv.cat alex.marti@estudiants.urv.cat marti.nadal@urv.cat
Identificador de l'autor: 0000-0002-9795-5967 0000-0001-8595-3772 0000-0002-8265-4096 0000-0003-4399-6138 0000-0002-0217-4827
Data d'alta del registre: 2024-11-30
Versió de l'article dipositat: info:eu-repo/semantics/acceptedVersion
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: Environmental Research. 196 (110941): 110941-
Referència de l'ítem segons les normes APA: Martinez, Maria Angeles; Gonzalez, Neus; Marti, Anna; Marques, Montse; Rovira, Joaquim; Kumar, Vikas; Nadal, Marti; (2021). Human biomonitoring of bisphenol A along pregnancy: An exposure reconstruction of the EXHES-Spain cohort. Environmental Research, 196(110941), 110941-. DOI: 10.1016/j.envres.2021.110941
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2021
Tipus de publicació: Journal Publications
Repositori URV