Autor segons l'article: Rodriguez-Tomas, Elisabet; Arenas, Meritxell; Gomez, Junior; Acosta, Johana; Trilla, Jordi; Lopez, Yolanda; Arquez, Miguel; Torres, Laura; Araguas, Pablo; Hernandez-Aguilera, Anna; Baiges-Gaya, Gerard; Castane, Helena; Camps, Jordi; Joven, Jorge;
Departament: Ciències Mèdiques Bàsiques Medicina i Cirurgia
Autor/s de la URV: Alkhoury, Nadine / Arenas Prat, Meritxell / Arquez Pianetta, Miguel / Baiges Gaya, Gerard / Camps Andreu, Jorge / Castañé Vilafranca, Helena / Gómez Alvarez, Josep / Joven Maried, Jorge / Rodriguez Tomas, Elisabet / Torres Hugas, Lluís / Trilla Martin, Jorge
Paraules clau: Valine Tumor recurrence Tumor marker Treatment response Treatment outcome Succinic acid Succinate-dehydrogenase Rectum tumor Rectum cancer Rectal neoplasms Radiation dose Protein blood level Protein Prospective study Pon1 protein, human Pilot study Performance Pathological complete response Paraoxonase-1 activity Oxidative stress Neoplasm recurrence, local Neoadjuvant therapy Middle aged Metabolism Male Ketoglutaric acids Humans Human Genetics Gene expression regulation, neoplastic Gene expression regulation Female Feasibility study Energy metabolism Early diagnosis Disease free survival Diarrhea Density-lipoprotein Controlled study Colorectal-cancer Clinical article Chromatography Chemoradiotherapy Carcinoembryonic antigen Capecitabine Cancer recurrence Blood Biomarkers, tumor Biological marker Aryldialkylphosphatase 1 Aryldialkylphosphatase Article Aged Adverse event Adult Adjuvant therapy 2 oxoglutaric acid
Resum: We report a pilot study on the feasibility of determinations of circulating levels of paraoxonase-1 (PON1) and compounds related to energy metabolism as biomarkers for the evaluation of patients with rectal cancer (RC), and the effects produced by neoadjuvant radiochemotherapy (NRCT). We studied 32 patients treated with radiotherapy plus capecitabine concomitant chemotherapy and 48 control subjects. We identified pre-NRCT PON1 and alpha-ketoglutarate as the parameters that best discriminated between RC patients and the control group. Receiver operating characteristics analysis of the combination of the two parameters showed an area under the curve (AUC) of 0.918. Moreover, patients who presented a pathological complete response (pCR) to treatment had lower plasma pre-NRCT valine concentrations (AUC of 0.826). Patients who had a relapse had lower concentrations of succinate (AUC of 0.833). The results of the present study illustrate the usefulness of investigating alterations in oxidative stress and metabolism in RC. Due to the small number of patients studied, our results must be considered preliminary, but they suggest that the determination of circulating levels of PON1 and alpha-ketoglutarate might be a valuable tool for the early diagnosis of RC, while the determination of valine and succinate might effectively predict pCR and the appearance of relapse.
Àrees temàtiques: Zootecnia / recursos pesqueiros Sociology Sociología Serviço social Saúde coletiva Química Psychology Psicología Planejamento urbano e regional / demografia Odontología Nutrição Multidisciplinary sciences Multidisciplinary Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Linguística e literatura Letras / linguística Interdisciplinary research in the social sciences Interdisciplinar Human geography and urban studies History & philosophy of science Historia Geografía Geociências General medicine General biochemistry,genetics and molecular biology General agricultural and biological sciences Farmacia Environmental studies Ensino Engenharias iv Engenharias iii Engenharias ii Engenharias i Enfermagem Educação física Educação Economia Direito Demography Comunicação e informação Ciências sociais aplicadas i Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência política e relações internacionais Ciência de alimentos Ciência da computação Biotecnología Biology Biodiversidade Biochemistry, genetics and molecular biology (miscellaneous) Astronomia / física Arquitetura, urbanismo e design Archaeology Antropologia / arqueologia Anthropology Agricultural and biological sciences (miscellaneous) Administração, ciências contábeis e turismo Administração pública e de empresas, ciências contábeis e turismo
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
Adreça de correu electrònic de l'autor: josep.gomez@urv.cat lluis.torres@urv.cat jorge.trilla@urv.cat miguel.arquez@urv.cat jorge.camps@urv.cat nadine.alkhoury@estudiants.urv.cat nadine.alkhoury@estudiants.urv.cat nadine.alkhoury@estudiants.urv.cat nadine.alkhoury@estudiants.urv.cat miguel.arquez@urv.cat helena.castane@estudiants.urv.cat gerard.baiges@estudiants.urv.cat elisabet.rodriguezt@estudiants.urv.cat elisabet.rodriguezt@estudiants.urv.cat meritxell.arenas@urv.cat jorge.joven@urv.cat
Identificador de l'autor: 0000-0002-0573-7621 0000-0002-3165-3640 0000-0003-0815-2570 0000-0003-2749-4541
Data d'alta del registre: 2024-07-27
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
Enllaç font original: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0250453
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: Plos One. 16 (4):
Referència de l'ítem segons les normes APA: Rodriguez-Tomas, Elisabet; Arenas, Meritxell; Gomez, Junior; Acosta, Johana; Trilla, Jordi; Lopez, Yolanda; Arquez, Miguel; Torres, Laura; Araguas, Pa (2021). Identification of potential metabolic biomarkers of rectal cancer and of the effect of neoadjuvant radiochemotherapy. Plos One, 16(4), -. DOI: 10.1371/journal.pone.0250453
DOI de l'article: 10.1371/journal.pone.0250453
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2021
Tipus de publicació: Journal Publications
Repositori URV