Autor según el artículo: Rodriguez-Tomas, Elisabet; Arenas, Meritxell; Gomez, Junior; Acosta, Johana; Trilla, Jordi; Lopez, Yolanda; Arquez, Miguel; Torres, Laura; Araguas, Pablo; Hernandez-Aguilera, Anna; Baiges-Gaya, Gerard; Castane, Helena; Camps, Jordi; Joven, Jorge
Departamento: Ciències Mèdiques Bàsiques; Medicina i Cirurgia
Autor/es de la URV: Alkhoury, Nadine / Arenas Prat, Meritxell / Arquez Pianetta, Miguel / Baiges Gaya, Gerard / Camps Andreu, Jorge / Castañé Vilafranca, Helena / Gómez Alvarez, Josep / Joven Maried, Jorge / Rodriguez Tomas, Elisabet / Trilla Martin, Jorge
Palabras clave: Valine; Tumor recurrence; Tumor marker; Treatment response; Treatment outcome; Succinic acid; Succinate-dehydrogenase; Rectum tumor; Rectum cancer; Rectal neoplasms; Radiation dose; Protein blood level; Protein; Prospective study; Pon1 protein, human; Pilot study; Performance; Pathological complete response; Paraoxonase-1 activity; Oxidative stress; Neoplasm recurrence, local; Neoadjuvant therapy; Middle aged; Metabolism; Male; Ketoglutaric acids; Humans; Human; Genetics; Gene expression regulation, neoplastic; Gene expression regulation; Female; Feasibility study; Energy metabolism; Early diagnosis; Disease free survival; Diarrhea; Density-lipoprotein; Controlled study; Colorectal-cancer; Clinical article; Chromatography; Chemoradiotherapy; Carcinoembryonic antigen; Capecitabine; Cancer recurrence; Blood; Biomarkers, tumor; Biological marker; Aryldialkylphosphatase 1; Aryldialkylphosphatase; Article; Aged; Adverse event; Adult; Adjuvant therapy; 2 oxoglutaric acid
Resumen: We report a pilot study on the feasibility of determinations of circulating levels of paraoxonase-1 (PON1) and compounds related to energy metabolism as biomarkers for the evaluation of patients with rectal cancer (RC), and the effects produced by neoadjuvant radiochemotherapy (NRCT). We studied 32 patients treated with radiotherapy plus capecitabine concomitant chemotherapy and 48 control subjects. We identified pre-NRCT PON1 and alpha-ketoglutarate as the parameters that best discriminated between RC patients and the control group. Receiver operating characteristics analysis of the combination of the two parameters showed an area under the curve (AUC) of 0.918. Moreover, patients who presented a pathological complete response (pCR) to treatment had lower plasma pre-NRCT valine concentrations (AUC of 0.826). Patients who had a relapse had lower concentrations of succinate (AUC of 0.833). The results of the present study illustrate the usefulness of investigating alterations in oxidative stress and metabolism in RC. Due to the small number of patients studied, our results must be considered preliminary, but they suggest that the determination of circulating levels of PON1 and alpha-ketoglutarate might be a valuable tool for the early diagnosis of RC, while the determination of valine and succinate might effectively predict pCR and the appearance of relapse.
Áreas temáticas: Zootecnia / recursos pesqueiros; Sociology; Sociología; Serviço social; Saúde coletiva; Química; Psychology; Psicología; Planejamento urbano e regional / demografia; Odontología; Nutrição; Multidisciplinary sciences; Multidisciplinary; Medicine (miscellaneous); Medicina veterinaria; Medicina iii; Medicina ii; Medicina i; Materiais; Matemática / probabilidade e estatística; Linguística e literatura; Letras / linguística; Interdisciplinary research in the social sciences; Interdisciplinar; Human geography and urban studies; History & philosophy of science; Historia; Geografía; Geociências; General medicine; General biochemistry,genetics and molecular biology; General agricultural and biological sciences; Farmacia; Environmental studies; Ensino; Engenharias iv; Engenharias iii; Engenharias ii; Engenharias i; Enfermagem; Educação física; Educação; Economia; Direito; Demography; Comunicação e informação; Ciencias sociales; Ciências sociais aplicadas i; Ciencias humanas; Ciências biológicas iii; Ciências biológicas ii; Ciências biológicas i; Ciências ambientais; Ciências agrárias i; Ciência política e relações internacionais; Ciência de alimentos; Ciência da computação; Biotecnología; Biology; Biodiversidade; Biochemistry, genetics and molecular biology (miscellaneous); Astronomia / física; Arquitetura, urbanismo e design; Archaeology; Antropologia / arqueologia; Anthropology; Agricultural and biological sciences (miscellaneous); Administração, ciências contábeis e turismo; Administração pública e de empresas, ciências contábeis e turismo
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: jorge.trilla@urv.cat; miguel.arquez@urv.cat; josep.gomez@urv.cat; jorge.camps@urv.cat; nadine.alkhoury@estudiants.urv.cat; nadine.alkhoury@estudiants.urv.cat; nadine.alkhoury@estudiants.urv.cat; nadine.alkhoury@estudiants.urv.cat; miguel.arquez@urv.cat; helena.castane@estudiants.urv.cat; gerard.baiges@estudiants.urv.cat; elisabet.rodriguezt@estudiants.urv.cat; elisabet.rodriguezt@estudiants.urv.cat; meritxell.arenas@urv.cat; jorge.joven@urv.cat
Fecha de alta del registro: 2025-08-09
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0250453
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Plos One. 16 (4): e0250453-
Referencia de l'ítem segons les normes APA: Rodriguez-Tomas, Elisabet; Arenas, Meritxell; Gomez, Junior; Acosta, Johana; Trilla, Jordi; Lopez, Yolanda; Arquez, Miguel; Torres, Laura; Araguas, Pa (2021). Identification of potential metabolic biomarkers of rectal cancer and of the effect of neoadjuvant radiochemotherapy. Plos One, 16(4), e0250453-. DOI: 10.1371/journal.pone.0250453
DOI del artículo: 10.1371/journal.pone.0250453
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2021
Tipo de publicación: Journal Publications
Repositori URV