Articles producció científicaMedicina i Cirurgia

Identification of potential metabolic biomarkers of rectal cancer and of the effect of neoadjuvant radiochemotherapy

  • Datos identificativos

    Identificador:  imarina:9216861
    Handle: https://hdl.handle.net/20.500.11797/imarina9216861
    Autores:  Rodriguez-Tomas, Elisabet; Arenas, Meritxell; Gomez, Junior; Acosta, Johana; Trilla, Jordi; Lopez, Yolanda; Arquez, Miguel; Torres, Laura; Araguas, Pablo; Hernandez-Aguilera, Anna; Baiges-Gaya, Gerard; Castane, Helena; Camps, Jordi; Joven, Jorge
    Resumen:
    We report a pilot study on the feasibility of determinations of circulating levels of paraoxonase-1 (PON1) and compounds related to energy metabolism as biomarkers for the evaluation of patients with rectal cancer (RC), and the effects produced by neoadjuvant radiochemotherapy (NRCT). We studied 32 patients treated with radiotherapy plus capecitabine concomitant chemotherapy and 48 control subjects. We identified pre-NRCT PON1 and alpha-ketoglutarate as the parameters that best discriminated between RC patients and the control group. Receiver operating characteristics analysis of the combination of the two parameters showed an area under the curve (AUC) of 0.918. Moreover, patients who presented a pathological complete response (pCR) to treatment had lower plasma pre-NRCT valine concentrations (AUC of 0.826). Patients who had a relapse had lower concentrations of succinate (AUC of 0.833). The results of the present study illustrate the usefulness of investigating alterations in oxidative stress and metabolism in RC. Due to the small number of patients studied, our results must be considered preliminary, but they suggest that the determination of circulating levels of PON1 and alpha-ketoglutarate might be a valuable tool for the early diagnosis of RC, while the determination of valine and succinate might effectively predict pCR and the appearance of relapse.

  • Otros:

    Enlace a la fuente original: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0250453
    Referencia de l'ítem segons les normes APA: Rodriguez-Tomas, Elisabet; Arenas, Meritxell; Gomez, Junior; Acosta, Johana; Trilla, Jordi; Lopez, Yolanda; Arquez, Miguel; Torres, Laura; Araguas, Pa (2021). Identification of potential metabolic biomarkers of rectal cancer and of the effect of neoadjuvant radiochemotherapy. Plos One, 16(4), e0250453-. DOI: 10.1371/journal.pone.0250453
    Referencia al articulo segun fuente origial: Plos One. 16 (4): e0250453-
    DOI del artículo: 10.1371/journal.pone.0250453
    Año de publicación de la revista: 2021
    Entidad: Universitat Rovira i Virgili
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    Fecha de alta del registro: 2025-08-09
    Autor/es de la URV: Alkhoury, Nadine / Arenas Prat, Meritxell / Arquez Pianetta, Miguel / Baiges Gaya, Gerard / Camps Andreu, Jorge / Castañé Vilafranca, Helena / Gómez Alvarez, Josep / Joven Maried, Jorge / Rodriguez Tomas, Elisabet / Trilla Martin, Jorge
    Departamento: Ciències Mèdiques Bàsiques, Medicina i Cirurgia
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    Tipo de publicación: Journal Publications
    Autor según el artículo: Rodriguez-Tomas, Elisabet; Arenas, Meritxell; Gomez, Junior; Acosta, Johana; Trilla, Jordi; Lopez, Yolanda; Arquez, Miguel; Torres, Laura; Araguas, Pablo; Hernandez-Aguilera, Anna; Baiges-Gaya, Gerard; Castane, Helena; Camps, Jordi; Joven, Jorge
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    Áreas temáticas: Zootecnia / recursos pesqueiros, Sociology, Sociología, Serviço social, Saúde coletiva, Química, Psychology, Psicología, Planejamento urbano e regional / demografia, Odontología, Nutrição, Multidisciplinary sciences, Multidisciplinary, Medicine (miscellaneous), Medicina veterinaria, Medicina iii, Medicina ii, Medicina i, Materiais, Matemática / probabilidade e estatística, Linguística e literatura, Letras / linguística, Interdisciplinary research in the social sciences, Interdisciplinar, Human geography and urban studies, History & philosophy of science, Historia, Geografía, Geociências, General medicine, General biochemistry,genetics and molecular biology, General agricultural and biological sciences, Farmacia, Environmental studies, Ensino, Engenharias iv, Engenharias iii, Engenharias ii, Engenharias i, Enfermagem, Educação física, Educação, Economia, Direito, Demography, Comunicação e informação, Ciencias sociales, Ciências sociais aplicadas i, Ciencias humanas, Ciências biológicas iii, Ciências biológicas ii, Ciências biológicas i, Ciências ambientais, Ciências agrárias i, Ciência política e relações internacionais, Ciência de alimentos, Ciência da computação, Biotecnología, Biology, Biodiversidade, Biochemistry, genetics and molecular biology (miscellaneous), Astronomia / física, Arquitetura, urbanismo e design, Archaeology, Antropologia / arqueologia, Anthropology, Agricultural and biological sciences (miscellaneous), Administração, ciências contábeis e turismo, Administração pública e de empresas, ciências contábeis e turismo
    Direcció de correo del autor: jorge.trilla@urv.cat, miguel.arquez@urv.cat, josep.gomez@urv.cat, jorge.camps@urv.cat, nadine.alkhoury@estudiants.urv.cat, nadine.alkhoury@estudiants.urv.cat, nadine.alkhoury@estudiants.urv.cat, nadine.alkhoury@estudiants.urv.cat, miguel.arquez@urv.cat, helena.castane@estudiants.urv.cat, gerard.baiges@estudiants.urv.cat, elisabet.rodriguezt@estudiants.urv.cat, elisabet.rodriguezt@estudiants.urv.cat, meritxell.arenas@urv.cat, jorge.joven@urv.cat

  • Palabras clave:

    Valine
    Tumor recurrence
    Tumor marker
    Treatment response
    Treatment outcome
    Succinic acid
    Succinate-dehydrogenase
    Rectum tumor
    Rectum cancer
    Rectal neoplasms
    Radiation dose
    Protein blood level
    Protein
    Prospective study
    Pon1 protein
    human
    Pilot study
    Performance
    Pathological complete response
    Paraoxonase-1 activity
    Oxidative stress
    Neoplasm recurrence
    local
    Neoadjuvant therapy
    Middle aged
    Metabolism
    Male
    Ketoglutaric acids
    Humans
    Genetics
    Gene expression regulation
    neoplastic
    Female
    Feasibility study
    Energy metabolism
    Early diagnosis
    Disease free survival
    Diarrhea
    Density-lipoprotein
    Controlled study
    Colorectal-cancer
    Clinical article
    Chromatography
    Chemoradiotherapy
    Carcinoembryonic antigen
    Capecitabine
    Cancer recurrence
    Blood
    Biomarkers
    tumor
    Biological marker
    Aryldialkylphosphatase 1
    Aryldialkylphosphatase
    Article
    Aged
    Adverse event
    Adult
    Adjuvant therapy
    2 oxoglutaric acid
    Agricultural and Biological Sciences (Miscellaneous)
    Biochemistry
    Genetics and Molecular Biology (Miscellaneous)
    Biology
    Medicine (Miscellaneous)
    Multidisciplinary
    Multidisciplinary Sciences
    Zootecnia / recursos pesqueiros
    Sociology
    Sociología
    Serviço social
    Saúde coletiva
    Química
    Psychology
    Psicología
    Planejamento urbano e regional / demografia
    Odontología
    Nutrição
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Materiais
    Matemática / probabilidade e estatística
    Linguística e literatura
    Letras / linguística
    Interdisciplinary research in the social sciences
    Interdisciplinar
    Human geography and urban studies
    History & philosophy of science
    Historia
    Geografía
    Geociências
    General medicine
    General biochemistry
    genetics and molecular biology
    General agricultural and biological sciences
    Farma

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