Articles producció científica> Medicina i Cirurgia

Prognostic Significance of Thyroglobulin Antibodies in Differentiated Thyroid Cancer

  • Dades identificatives

    Identificador: imarina:9216879
    Autors:
    Reverter, Jordi L.Rosas-Allende, IrenePuig-Jove, CarlosZafon, CarlesMegia, AnaCastells, IgnasiPizarro, EduardaPuig-Domingo, ManelGranada, M. Luisa
    Resum:
    Objective. To investigate whether variations in thyroglobulin autoantibodies (TgAb) are related to the recurrence or persistence of differentiated thyroid carcinoma (DTC) and may therefore be useful as surrogate tumor markers. Design and Methods. We retrospectively studied 98 subjects (83 women, 47 +/- 15 years old) from an initial cohort of 1017 patients treated for DTC in five hospitals, with positive TgAb at any time during the follow-up. Patients presented five different patterns of evolution of serum TgAb concentrations: (1) stable positive TgAb, (2) de novo appearance, (3) an increase of more than 50%, (4) TgAb levels from positive to negative, and (5) a decrease of more than 50%. Results. In the group of 11 patients with stable TgAb, four cases presented persistence of the disease with structural incomplete response. In the group of 22 patients with sustained increasing trend rising more than 50% or de novo detectable TgAb levels, three patients were diagnosed with structural incomplete response. There was no evidence of recurrence or persistence of the disease in any of the 65 patients who showed a significant decrease in (n = 35) or disappearance of (n = 30) TgAb. Conclusions. Our results suggest that not only the appearance of a significant increase in TgAb but also stable concentrations of TgAb should be regarded as a sufficient risk condition for an active search for recurrent or persistent disease. Conversely, a significant decrease in TgAb levels can represent a good prognostic sign.
  • Altres:

    Autor segons l'article: Reverter, Jordi L.; Rosas-Allende, Irene; Puig-Jove, Carlos; Zafon, Carles; Megia, Ana; Castells, Ignasi; Pizarro, Eduarda; Puig-Domingo, Manel; Granada, M. Luisa;
    Departament: Medicina i Cirurgia
    Autor/s de la URV: Megía Colet, Ana
    Paraules clau: Serum antithyroglobulin antibody Recurrence Papillary Negative patients Level Follow-up Clinical impact Carcinoma Assays
    Resum: Objective. To investigate whether variations in thyroglobulin autoantibodies (TgAb) are related to the recurrence or persistence of differentiated thyroid carcinoma (DTC) and may therefore be useful as surrogate tumor markers. Design and Methods. We retrospectively studied 98 subjects (83 women, 47 +/- 15 years old) from an initial cohort of 1017 patients treated for DTC in five hospitals, with positive TgAb at any time during the follow-up. Patients presented five different patterns of evolution of serum TgAb concentrations: (1) stable positive TgAb, (2) de novo appearance, (3) an increase of more than 50%, (4) TgAb levels from positive to negative, and (5) a decrease of more than 50%. Results. In the group of 11 patients with stable TgAb, four cases presented persistence of the disease with structural incomplete response. In the group of 22 patients with sustained increasing trend rising more than 50% or de novo detectable TgAb levels, three patients were diagnosed with structural incomplete response. There was no evidence of recurrence or persistence of the disease in any of the 65 patients who showed a significant decrease in (n = 35) or disappearance of (n = 30) TgAb. Conclusions. Our results suggest that not only the appearance of a significant increase in TgAb but also stable concentrations of TgAb should be regarded as a sufficient risk condition for an active search for recurrent or persistent disease. Conversely, a significant decrease in TgAb levels can represent a good prognostic sign.
    Àrees temàtiques: Medicina veterinaria Medicina ii Medicina i Farmacia Endocrinology, diabetes and metabolism Endocrinology & metabolism
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    Adreça de correu electrònic de l'autor: ana.megia@urv.cat
    Identificador de l'autor: 0000-0002-5101-9452
    Data d'alta del registre: 2023-02-19
    Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
    Enllaç font original: https://www.hindawi.com/journals/jtr/2020/8312628/
    Referència a l'article segons font original: Journal Of Thyroid Research. 2020 (8312628):
    Referència de l'ítem segons les normes APA: Reverter, Jordi L.; Rosas-Allende, Irene; Puig-Jove, Carlos; Zafon, Carles; Megia, Ana; Castells, Ignasi; Pizarro, Eduarda; Puig-Domingo, Manel; Grana (2020). Prognostic Significance of Thyroglobulin Antibodies in Differentiated Thyroid Cancer. Journal Of Thyroid Research, 2020(8312628), -. DOI: 10.1155/2020/8312628
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    DOI de l'article: 10.1155/2020/8312628
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2020
    Tipus de publicació: Journal Publications
  • Paraules clau:

    Endocrinology & Metabolism,Endocrinology, Diabetes and Metabolism
    Serum antithyroglobulin antibody
    Recurrence
    Papillary
    Negative patients
    Level
    Follow-up
    Clinical impact
    Carcinoma
    Assays
    Medicina veterinaria
    Medicina ii
    Medicina i
    Farmacia
    Endocrinology, diabetes and metabolism
    Endocrinology & metabolism
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