Articles producció científica> Medicina i Cirurgia

Prognostic Significance of Thyroglobulin Antibodies in Differentiated Thyroid Cancer

  • Identification data

    Identifier: imarina:9216879
    Authors:
    Reverter, Jordi L.Rosas-Allende, IrenePuig-Jove, CarlosZafon, CarlesMegia, AnaCastells, IgnasiPizarro, EduardaPuig-Domingo, ManelGranada, M. Luisa
    Abstract:
    Objective. To investigate whether variations in thyroglobulin autoantibodies (TgAb) are related to the recurrence or persistence of differentiated thyroid carcinoma (DTC) and may therefore be useful as surrogate tumor markers. Design and Methods. We retrospectively studied 98 subjects (83 women, 47 +/- 15 years old) from an initial cohort of 1017 patients treated for DTC in five hospitals, with positive TgAb at any time during the follow-up. Patients presented five different patterns of evolution of serum TgAb concentrations: (1) stable positive TgAb, (2) de novo appearance, (3) an increase of more than 50%, (4) TgAb levels from positive to negative, and (5) a decrease of more than 50%. Results. In the group of 11 patients with stable TgAb, four cases presented persistence of the disease with structural incomplete response. In the group of 22 patients with sustained increasing trend rising more than 50% or de novo detectable TgAb levels, three patients were diagnosed with structural incomplete response. There was no evidence of recurrence or persistence of the disease in any of the 65 patients who showed a significant decrease in (n = 35) or disappearance of (n = 30) TgAb. Conclusions. Our results suggest that not only the appearance of a significant increase in TgAb but also stable concentrations of TgAb should be regarded as a sufficient risk condition for an active search for recurrent or persistent disease. Conversely, a significant decrease in TgAb levels can represent a good prognostic sign.
  • Others:

    Author, as appears in the article.: Reverter, Jordi L.; Rosas-Allende, Irene; Puig-Jove, Carlos; Zafon, Carles; Megia, Ana; Castells, Ignasi; Pizarro, Eduarda; Puig-Domingo, Manel; Granada, M. Luisa;
    Department: Medicina i Cirurgia
    URV's Author/s: MegĂ­a Colet, Ana
    Keywords: Serum antithyroglobulin antibody Recurrence Papillary Negative patients Level Follow-up Clinical impact Carcinoma Assays
    Abstract: Objective. To investigate whether variations in thyroglobulin autoantibodies (TgAb) are related to the recurrence or persistence of differentiated thyroid carcinoma (DTC) and may therefore be useful as surrogate tumor markers. Design and Methods. We retrospectively studied 98 subjects (83 women, 47 +/- 15 years old) from an initial cohort of 1017 patients treated for DTC in five hospitals, with positive TgAb at any time during the follow-up. Patients presented five different patterns of evolution of serum TgAb concentrations: (1) stable positive TgAb, (2) de novo appearance, (3) an increase of more than 50%, (4) TgAb levels from positive to negative, and (5) a decrease of more than 50%. Results. In the group of 11 patients with stable TgAb, four cases presented persistence of the disease with structural incomplete response. In the group of 22 patients with sustained increasing trend rising more than 50% or de novo detectable TgAb levels, three patients were diagnosed with structural incomplete response. There was no evidence of recurrence or persistence of the disease in any of the 65 patients who showed a significant decrease in (n = 35) or disappearance of (n = 30) TgAb. Conclusions. Our results suggest that not only the appearance of a significant increase in TgAb but also stable concentrations of TgAb should be regarded as a sufficient risk condition for an active search for recurrent or persistent disease. Conversely, a significant decrease in TgAb levels can represent a good prognostic sign.
    Thematic Areas: Medicina veterinaria Medicina ii Medicina i Farmacia Endocrinology, diabetes and metabolism Endocrinology & metabolism
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: ana.megia@urv.cat
    Author identifier: 0000-0002-5101-9452
    Record's date: 2023-02-19
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.hindawi.com/journals/jtr/2020/8312628/
    Papper original source: Journal Of Thyroid Research. 2020 (8312628):
    APA: Reverter, Jordi L.; Rosas-Allende, Irene; Puig-Jove, Carlos; Zafon, Carles; Megia, Ana; Castells, Ignasi; Pizarro, Eduarda; Puig-Domingo, Manel; Grana (2020). Prognostic Significance of Thyroglobulin Antibodies in Differentiated Thyroid Cancer. Journal Of Thyroid Research, 2020(8312628), -. DOI: 10.1155/2020/8312628
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Article's DOI: 10.1155/2020/8312628
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2020
    Publication Type: Journal Publications
  • Keywords:

    Endocrinology & Metabolism,Endocrinology, Diabetes and Metabolism
    Serum antithyroglobulin antibody
    Recurrence
    Papillary
    Negative patients
    Level
    Follow-up
    Clinical impact
    Carcinoma
    Assays
    Medicina veterinaria
    Medicina ii
    Medicina i
    Farmacia
    Endocrinology, diabetes and metabolism
    Endocrinology & metabolism
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