Articles producció científica> Ciències Mèdiques Bàsiques

High and Low Haemoglobin Levels in Early Pregnancy Are Associated to a Higher Risk of Miscarriage: A Population-Based Cohort Study

  • Dades identificatives

    Identificador: imarina:9220598
    Autors:
    Diaz-Lopez, AndresRibot, BlancaBasora, JosepArija, Victoria
    Resum:
    To evaluate whether women with anaemia or high haemoglobin (Hb) in early pregnancy would be at higher risk of miscarriage, this population-based cohort study involved 9453 women whose pregnancies were monitored at primary care centres between 2007 and 2012. The computerised clinical histories were used to collect: Hb measurements (up to 14 weeks of gestation), miscarriage before or by 24 weeks of gestation, and other maternal characteristics. The relation between anaemia (Hb < 110 g/L), normal Hb (110-140 g/L, reference), and high Hb concentrations (>= 140 g/L) with miscarriage were expressed as adjusted OR with 95%CI. Restricted cubic spline models were applied to evaluate the dose-response relationships. A total of 520 (5.5%) women were recorded as having a miscarriage. The rate of miscarriage in anaemia, normal Hb, and high Hb concentrations was 8.4%, 5.1%, and 10.2%, respectively. Compared with women with normal Hb at the first trimester, the multivariable-adjusted OR for miscarriage was 2.11 (95%CI, 1.38-3.21) for women with anaemia and 1.83 (95%CI, 1.29-2.58) for women with high Hb. Hb concentrations showed a U-shaped association with miscarriage, with the lowest incidence among women with Hb of 120-130 g/L. These data highlight the importance of considering anaemia and high Hb levels in early pregnancy as harmful indicators for miscarriage.
  • Altres:

    Autor segons l'article: Diaz-Lopez, Andres; Ribot, Blanca; Basora, Josep; Arija, Victoria;
    Departament: Ciències Mèdiques Bàsiques
    Autor/s de la URV: Arija Val, Maria Victoria / Basora Gallisa, Josep / Díaz López, Andres / RIBOT SERRA, BLANCA
    Paraules clau: Young adult Trimester Spontaneous abortion Risk factors Risk factor Protein expression Primary medical care Prevention perspective Pregnant woman Pregnancy trimester, first Pregnancy loss Pregnancy complications, hematologic Pregnancy complication Pregnancy Odds ratio Miscarriage Middle aged Mechanisms Maternal hemoglobin Major clinical study Longitudinal study Incidence Humans Human High hb concentration Hepcidin Hemoglobins Hemoglobin determination Hemoglobin blood level Hemoglobin Hemoconcentration First trimester pregnancy Female Confidence interval Complication Cohort studies Cohort analysis Blood Birth Article Anemia Anaemia Adult Abortion, spontaneous 1st
    Resum: To evaluate whether women with anaemia or high haemoglobin (Hb) in early pregnancy would be at higher risk of miscarriage, this population-based cohort study involved 9453 women whose pregnancies were monitored at primary care centres between 2007 and 2012. The computerised clinical histories were used to collect: Hb measurements (up to 14 weeks of gestation), miscarriage before or by 24 weeks of gestation, and other maternal characteristics. The relation between anaemia (Hb < 110 g/L), normal Hb (110-140 g/L, reference), and high Hb concentrations (>= 140 g/L) with miscarriage were expressed as adjusted OR with 95%CI. Restricted cubic spline models were applied to evaluate the dose-response relationships. A total of 520 (5.5%) women were recorded as having a miscarriage. The rate of miscarriage in anaemia, normal Hb, and high Hb concentrations was 8.4%, 5.1%, and 10.2%, respectively. Compared with women with normal Hb at the first trimester, the multivariable-adjusted OR for miscarriage was 2.11 (95%CI, 1.38-3.21) for women with anaemia and 1.83 (95%CI, 1.29-2.58) for women with high Hb. Hb concentrations showed a U-shaped association with miscarriage, with the lowest incidence among women with Hb of 120-130 g/L. These data highlight the importance of considering anaemia and high Hb levels in early pregnancy as harmful indicators for miscarriage.
    Àrees temàtiques: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    Adreça de correu electrònic de l'autor: josep.basora@urv.cat andres.diaz@urv.cat josep.basora@urv.cat victoria.arija@urv.cat
    Identificador de l'autor: 0000-0002-7500-5629 0000-0002-1758-0975
    Data d'alta del registre: 2024-07-27
    Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
    Enllaç font original: https://www.mdpi.com/2072-6643/13/5/1578
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referència a l'article segons font original: Nutrients. 13 (5):
    Referència de l'ítem segons les normes APA: Diaz-Lopez, Andres; Ribot, Blanca; Basora, Josep; Arija, Victoria; (2021). High and Low Haemoglobin Levels in Early Pregnancy Are Associated to a Higher Risk of Miscarriage: A Population-Based Cohort Study. Nutrients, 13(5), -. DOI: 10.3390/nu13051578
    DOI de l'article: 10.3390/nu13051578
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2021
    Tipus de publicació: Journal Publications
  • Paraules clau:

    Food Science,Nutrition & Dietetics,Nutrition and Dietetics
    Young adult
    Trimester
    Spontaneous abortion
    Risk factors
    Risk factor
    Protein expression
    Primary medical care
    Prevention perspective
    Pregnant woman
    Pregnancy trimester, first
    Pregnancy loss
    Pregnancy complications, hematologic
    Pregnancy complication
    Pregnancy
    Odds ratio
    Miscarriage
    Middle aged
    Mechanisms
    Maternal hemoglobin
    Major clinical study
    Longitudinal study
    Incidence
    Humans
    Human
    High hb concentration
    Hepcidin
    Hemoglobins
    Hemoglobin determination
    Hemoglobin blood level
    Hemoglobin
    Hemoconcentration
    First trimester pregnancy
    Female
    Confidence interval
    Complication
    Cohort studies
    Cohort analysis
    Blood
    Birth
    Article
    Anemia
    Anaemia
    Adult
    Abortion, spontaneous
    1st
    Zootecnia / recursos pesqueiros
    Saúde coletiva
    Química
    Psicología
    Planejamento urbano e regional / demografia
    Nutrition and dietetics
    Nutrition & dietetics
    Nutrição
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    Food science
    Farmacia
    Engenharias iv
    Engenharias ii
    Enfermagem
    Educação física
    Economia
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências agrárias i
    Ciência de alimentos
    Biotecnología
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