Autor segons l'article: Diaz-Lopez, Andres; Ribot, Blanca; Basora, Josep; Arija, Victoria;
Departament: Ciències Mèdiques Bàsiques
Autor/s de la URV: Arija Val, Maria Victoria / Basora Gallisa, Josep / Díaz López, Andres / RIBOT SERRA, BLANCA
Paraules clau: Young adult Trimester Spontaneous abortion Risk factors Risk factor Protein expression Primary medical care Prevention perspective Pregnant woman Pregnancy trimester, first Pregnancy loss Pregnancy complications, hematologic Pregnancy complication Pregnancy Odds ratio Miscarriage Middle aged Mechanisms Maternal hemoglobin Major clinical study Longitudinal study Incidence Humans Human High hb concentration Hepcidin Hemoglobins Hemoglobin determination Hemoglobin blood level Hemoglobin Hemoconcentration First trimester pregnancy Female Confidence interval Complication Cohort studies Cohort analysis Blood Birth Article Anemia Anaemia Adult Abortion, spontaneous 1st
Resum: To evaluate whether women with anaemia or high haemoglobin (Hb) in early pregnancy would be at higher risk of miscarriage, this population-based cohort study involved 9453 women whose pregnancies were monitored at primary care centres between 2007 and 2012. The computerised clinical histories were used to collect: Hb measurements (up to 14 weeks of gestation), miscarriage before or by 24 weeks of gestation, and other maternal characteristics. The relation between anaemia (Hb < 110 g/L), normal Hb (110-140 g/L, reference), and high Hb concentrations (>= 140 g/L) with miscarriage were expressed as adjusted OR with 95%CI. Restricted cubic spline models were applied to evaluate the dose-response relationships. A total of 520 (5.5%) women were recorded as having a miscarriage. The rate of miscarriage in anaemia, normal Hb, and high Hb concentrations was 8.4%, 5.1%, and 10.2%, respectively. Compared with women with normal Hb at the first trimester, the multivariable-adjusted OR for miscarriage was 2.11 (95%CI, 1.38-3.21) for women with anaemia and 1.83 (95%CI, 1.29-2.58) for women with high Hb. Hb concentrations showed a U-shaped association with miscarriage, with the lowest incidence among women with Hb of 120-130 g/L. These data highlight the importance of considering anaemia and high Hb levels in early pregnancy as harmful indicators for miscarriage.
Àrees temàtiques: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
Adreça de correu electrònic de l'autor: josep.basora@urv.cat andres.diaz@urv.cat josep.basora@urv.cat victoria.arija@urv.cat
Identificador de l'autor: 0000-0002-7500-5629 0000-0002-1758-0975
Data d'alta del registre: 2024-07-27
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: Nutrients. 13 (5):
Referència de l'ítem segons les normes APA: Diaz-Lopez, Andres; Ribot, Blanca; Basora, Josep; Arija, Victoria; (2021). High and Low Haemoglobin Levels in Early Pregnancy Are Associated to a Higher Risk of Miscarriage: A Population-Based Cohort Study. Nutrients, 13(5), -. DOI: 10.3390/nu13051578
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2021
Tipus de publicació: Journal Publications
Repositori URV