Autor según el artículo: Diaz-Lopez, Andres; Ribot, Blanca; Basora, Josep; Arija, Victoria;
Departamento: Ciències Mèdiques Bàsiques
Autor/es de la URV: Arija Val, Maria Victoria / Basora Gallisa, Josep / Díaz López, Andres / RIBOT SERRA, BLANCA
Palabras clave: Young adult Trimester Spontaneous abortion Risk factors Risk factor Protein expression Primary medical care Prevention perspective Pregnant woman Pregnancy trimester, first Pregnancy loss Pregnancy complications, hematologic Pregnancy complication Pregnancy Odds ratio Miscarriage Middle aged Mechanisms Maternal hemoglobin Major clinical study Longitudinal study Incidence Humans Human High hb concentration Hepcidin Hemoglobins Hemoglobin determination Hemoglobin blood level Hemoglobin Hemoconcentration First trimester pregnancy Female Confidence interval Complication Cohort studies Cohort analysis Blood Birth Article Anemia Anaemia Adult Abortion, spontaneous 1st
Resumen: To evaluate whether women with anaemia or high haemoglobin (Hb) in early pregnancy would be at higher risk of miscarriage, this population-based cohort study involved 9453 women whose pregnancies were monitored at primary care centres between 2007 and 2012. The computerised clinical histories were used to collect: Hb measurements (up to 14 weeks of gestation), miscarriage before or by 24 weeks of gestation, and other maternal characteristics. The relation between anaemia (Hb < 110 g/L), normal Hb (110-140 g/L, reference), and high Hb concentrations (>= 140 g/L) with miscarriage were expressed as adjusted OR with 95%CI. Restricted cubic spline models were applied to evaluate the dose-response relationships. A total of 520 (5.5%) women were recorded as having a miscarriage. The rate of miscarriage in anaemia, normal Hb, and high Hb concentrations was 8.4%, 5.1%, and 10.2%, respectively. Compared with women with normal Hb at the first trimester, the multivariable-adjusted OR for miscarriage was 2.11 (95%CI, 1.38-3.21) for women with anaemia and 1.83 (95%CI, 1.29-2.58) for women with high Hb. Hb concentrations showed a U-shaped association with miscarriage, with the lowest incidence among women with Hb of 120-130 g/L. These data highlight the importance of considering anaemia and high Hb levels in early pregnancy as harmful indicators for miscarriage.
Áreas temáticas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: josep.basora@urv.cat andres.diaz@urv.cat josep.basora@urv.cat victoria.arija@urv.cat
Identificador del autor: 0000-0002-7500-5629 0000-0002-1758-0975
Fecha de alta del registro: 2024-07-27
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Nutrients. 13 (5):
Referencia de l'ítem segons les normes APA: Diaz-Lopez, Andres; Ribot, Blanca; Basora, Josep; Arija, Victoria; (2021). High and Low Haemoglobin Levels in Early Pregnancy Are Associated to a Higher Risk of Miscarriage: A Population-Based Cohort Study. Nutrients, 13(5), -. DOI: 10.3390/nu13051578
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2021
Tipo de publicación: Journal Publications
Repositori URV