Articles producció científica> Ciències Mèdiques Bàsiques

PKA and PKC Balance in Synapse Elimination during Neuromuscular Junction Development

  • Dades identificatives

    Identificador: imarina:9220663
  • Autors:

    Garcia, Neus
    Lanuza, Maria A.
    Tomas, Marta
    Cilleros-Mane, Victor
    Just-Borras, Laia
    Duran, Maria
    Polishchuk, Aleksandra
    Tomas, Josep
  • Altres:

    Autor segons l'article: Garcia, Neus; Lanuza, Maria A.; Tomas, Marta; Cilleros-Mane, Victor; Just-Borras, Laia; Duran, Maria; Polishchuk, Aleksandra; Tomas, Josep;
    Departament: Ciències Mèdiques Bàsiques
    e-ISSN: 2073-4409
    Autor/s de la URV: Cilleros Mañé, Víctor / DURAN ROMASEWSKYS, MARIA SOLEDAD / Garcia Sancho, Maria de les Neus / Just Borràs, Laia / Lanuza Escolano, María Angel / POLISHCHUK, ALEKSANDRA / Tomás Ferré, José Maria / Tomas Marginet, Marta
    Paraules clau: Tropomyosin Transgenic mouse Synaptogenesis Synaptic transmission Synapse Sodium Signal transduction Receptors Protein kinases Protein kinase c Protein expression Protein Presynaptic terminals Postnatal synapse elimination Pkc Pka Phorbol 13 acetate 12 myristate Nonhuman Nicotinic receptor Nicotinic acetylcholine receptor clusters Neurotrophin receptor Neurotrophic factor Neurotransmitter Neuromuscular junction Neurogenesis Nervous system development Nervous system Nerve ending Musculoskeletal development Muscarinic receptor Muscarinic m4 receptor Muscarinic m3 receptor Muscarinic m2 receptor Muscarinic m1 receptor Mouse Motor end-plate Motor end plate Mice, transgenic Mice Metabotropic receptor Metabolism Maturation Growth, development and aging Genetics Gene expression Decision making Cyclic amp-dependent protein kinases Cyclic amp dependent protein kinase Confocal microscopy Competition Chelerythrine Calphostin c Axonal competition Axon Article Animals Animal tissue Animal model Animal experiment Animal Alpha bungarotoxin Adenosine receptor Adenosine a2a receptor Adenosine a1 receptor Adenosine 3',5' phosphorothioate Adenosine Acetylcholine release 8 bromo cyclic amp 12 deoxyphorbol derivative
    Resum: During the development of the nervous system, synaptogenesis occurs in excess though only the appropriate connections consolidate. At the neuromuscular junction, competition between several motor nerve terminals results in the maturation of a single axon and the elimination of the others. The activity-dependent release of transmitter, cotransmitters, and neurotrophic factors allows the direct mutual influence between motor axon terminals through receptors such as presynaptic muscarinic ACh autoreceptors and the tropomyosin-related kinase B neurotrophin receptor. In previous studies, we investigated the synergistic and antagonistic relations between these receptors and their downstream coupling to PKA and PKC pathways and observed a metabotropic receptor-driven balance between PKA (stabilizes multinnervation) and PKC (promotes developmental axonal loss). However, how much does each kinase contribute in the developmental synapse elimination process? A detailed statistical analysis of the differences between the PKA and PKC effects in the synapse elimination could help to explore this point. The present short communication provides this analysis and results show that a similar level of PKA inhibition and PKC potentiation would be required during development to promote synapse loss.
    Àrees temàtiques: Medicine (miscellaneous) Cell biology Biochemistry, genetics and molecular biology (miscellaneous) Biochemistry, genetics and molecular biology (all)
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    Adreça de correu electrònic de l'autor: aleksandra.polishchuk@urv.cat laia.just@urv.cat marta.tomas@urv.cat aleksandra.polishchuk@urv.cat victor.cilleros@urv.cat josepmaria.tomas@urv.cat laia.just@urv.cat mariaangel.lanuza@urv.cat
    Identificador de l'autor: 0000-0001-6445-1538 0000-0003-0473-3730 0000-0002-4151-1697 0000-0001-6445-1538 0000-0001-5690-9932 0000-0002-0406-0006 0000-0003-0473-3730 0000-0003-4795-4103
    Data d'alta del registre: 2024-07-27
    Volum de revista: 10
    Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
    Enllaç font original: https://www.mdpi.com/2073-4409/10/6/1384
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referència a l'article segons font original: Cells. 10 (6): 1384-
    Referència de l'ítem segons les normes APA: Garcia, Neus; Lanuza, Maria A.; Tomas, Marta; Cilleros-Mane, Victor; Just-Borras, Laia; Duran, Maria; Polishchuk, Aleksandra; Tomas, Josep; (2021). PKA and PKC Balance in Synapse Elimination during Neuromuscular Junction Development. Cells, 10(6), 1384-. DOI: 10.3390/cells10061384
    DOI de l'article: 10.3390/cells10061384
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2021
    Tipus de publicació: Journal Publications
  • Paraules clau:

    Biochemistry, Genetics and Molecular Biology (Miscellaneous),Cell Biology,Medicine (Miscellaneous)
    Tropomyosin
    Transgenic mouse
    Synaptogenesis
    Synaptic transmission
    Synapse
    Sodium
    Signal transduction
    Receptors
    Protein kinases
    Protein kinase c
    Protein expression
    Protein
    Presynaptic terminals
    Postnatal synapse elimination
    Pkc
    Pka
    Phorbol 13 acetate 12 myristate
    Nonhuman
    Nicotinic receptor
    Nicotinic acetylcholine receptor clusters
    Neurotrophin receptor
    Neurotrophic factor
    Neurotransmitter
    Neuromuscular junction
    Neurogenesis
    Nervous system development
    Nervous system
    Nerve ending
    Musculoskeletal development
    Muscarinic receptor
    Muscarinic m4 receptor
    Muscarinic m3 receptor
    Muscarinic m2 receptor
    Muscarinic m1 receptor
    Mouse
    Motor end-plate
    Motor end plate
    Mice, transgenic
    Mice
    Metabotropic receptor
    Metabolism
    Maturation
    Growth, development and aging
    Genetics
    Gene expression
    Decision making
    Cyclic amp-dependent protein kinases
    Cyclic amp dependent protein kinase
    Confocal microscopy
    Competition
    Chelerythrine
    Calphostin c
    Axonal competition
    Axon
    Article
    Animals
    Animal tissue
    Animal model
    Animal experiment
    Animal
    Alpha bungarotoxin
    Adenosine receptor
    Adenosine a2a receptor
    Adenosine a1 receptor
    Adenosine 3',5' phosphorothioate
    Adenosine
    Acetylcholine release
    8 bromo cyclic amp
    12 deoxyphorbol derivative
    Medicine (miscellaneous)
    Cell biology
    Biochemistry, genetics and molecular biology (miscellaneous)
    Biochemistry, genetics and molecular biology (all)
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