Articles producció científica> Medicina i Cirurgia

Clinical characteristics and prognostic implications of diabetes and myocardial injury in patients admitted to the emergency room

  • Dades identificatives

    Identificador: imarina:9227040
    Autors:
    Bonet, GilCarrasquer, AnnaPeiro, Oscar M.Sanchez-Gimenez, RaulLal-Trehan, Nishadel-Moral-Ronda, VictorFort-Gallifa, IsabelBardaji, Alfredo
    Resum:
    Background This study aimed to investigate the clinical features and prognosis of diabetes and myocardial injury in patients admitted to the emergency department. Methods We analyzed the clinical data of all consecutive patients admitted to the emergency department during the years 2012 and 2013 with at least 1 cardiac Troponin I (cTnI Ultra Siemens, Advia Centaur) determination, and were classified according to the status of diabetes mellitus (DM) and myocardial injury (MI). Clinical events were evaluated in a 4-year follow-up. Results A total of 3622 patients were classified according to the presence of DM (n = 924 (25.55%)) and MI (n = 1049 (28.96%)). The proportion of MI in patients with DM was 40% and 25% in patients without DM. Mortality during follow-up was 10.9% in non-DM patients without MI, 21.3% in DM patients without MI, 40.1% in non-DM patients with MI, and 52.8% in DM patients with MI. A competitive risk model was used to obtain the Hazard Ratio (HR) for readmission for myocardial infarction or heart failure. There was a similar proportion of readmission for myocardial infarction and heart failure at a four-year follow-up in patients with DM or MI, which was much higher when DM was associated with MI, with respect to patients without DM or MI. The HR (95% Coefficient Interval) for myocardial infarction in the DM without MI, non-DM with MI, and DM with MI groups with respect to the non-DM without MI group was 2511 (1592-3960), 2682 (1739-4138), and 5036 (3221-7876), respectively. The HR (95% CI) for the risk of readmission for heart failure in the DM without MI, non-DM with MI, and DM with MI groups with respect to the non-DM without MI group was 2663 (1825-3886), 2562 (1753-3744) and 4292 (2936-6274), respectively. Conclusions The association of DM and MI
  • Altres:

    Autor segons l'article: Bonet, Gil; Carrasquer, Anna; Peiro, Oscar M.; Sanchez-Gimenez, Raul; Lal-Trehan, Nisha; del-Moral-Ronda, Victor; Fort-Gallifa, Isabel; Bardaji, Alfredo;
    Departament: Medicina i Cirurgia
    Autor/s de la URV: Bardají Ruiz, Alfredo / Bonet Pineda, Gil / Carrasquer Cucarella, Ana Maria / Peiró Ibáñez, Óscar Manuel / Sánchez Giménez, Raúl
    Paraules clau: Type-2 Troponin i Time factors Spain Risk factors Risk assessment Risk Retrospective studies Prognosis Prevention Patient readmission Patient admission Outcomes Myocardial injury Myocardial infarction Mortality Middle aged Mellitus Male Humans Heart failure Female Emergency service, hospital Disease progression Diabetes mellitus Diabetes Cardiovascular-disease Cardiac troponin-t Cardiac troponin Biomarkers Aged, 80 and over Aged Adults
    Resum: Background This study aimed to investigate the clinical features and prognosis of diabetes and myocardial injury in patients admitted to the emergency department. Methods We analyzed the clinical data of all consecutive patients admitted to the emergency department during the years 2012 and 2013 with at least 1 cardiac Troponin I (cTnI Ultra Siemens, Advia Centaur) determination, and were classified according to the status of diabetes mellitus (DM) and myocardial injury (MI). Clinical events were evaluated in a 4-year follow-up. Results A total of 3622 patients were classified according to the presence of DM (n = 924 (25.55%)) and MI (n = 1049 (28.96%)). The proportion of MI in patients with DM was 40% and 25% in patients without DM. Mortality during follow-up was 10.9% in non-DM patients without MI, 21.3% in DM patients without MI, 40.1% in non-DM patients with MI, and 52.8% in DM patients with MI. A competitive risk model was used to obtain the Hazard Ratio (HR) for readmission for myocardial infarction or heart failure. There was a similar proportion of readmission for myocardial infarction and heart failure at a four-year follow-up in patients with DM or MI, which was much higher when DM was associated with MI, with respect to patients without DM or MI. The HR (95% Coefficient Interval) for myocardial infarction in the DM without MI, non-DM with MI, and DM with MI groups with respect to the non-DM without MI group was 2511 (1592-3960), 2682 (1739-4138), and 5036 (3221-7876), respectively. The HR (95% CI) for the risk of readmission for heart failure in the DM without MI, non-DM with MI, and DM with MI groups with respect to the non-DM without MI group was 2663 (1825-3886), 2562 (1753-3744) and 4292 (2936-6274), respectively. Conclusions The association of DM and MI in patients treated in an Emergency Service identifies patients at very high risk of mortality and cardiovascular events.
    Àrees temàtiques: Saúde coletiva Psicología Medicina iii Medicina ii Medicina i Matemática / probabilidade e estatística Interdisciplinar Farmacia Educação física Ciências biológicas ii Ciências biológicas i Cardiology and cardiovascular medicine Cardiac & cardiovascular systems Biotecnología
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 1471-2261
    Adreça de correu electrònic de l'autor: gil.bonet@urv.cat oscarmanuel.peiro@urv.cat anamaria.carrasquer@urv.cat raul.sanchez@estudiants.urv.cat oscarmanuel.peiro@urv.cat anamaria.carrasquer@urv.cat alfredo.bardaji@urv.cat
    Identificador de l'autor: 0000-0003-1900-6974
    Data d'alta del registre: 2024-08-03
    Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
    Enllaç font original: https://bmccardiovascdisord.biomedcentral.com/articles/10.1186/s12872-021-02220-1
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referència a l'article segons font original: Bmc Cardiovascular Disorders. 21 (1): 414-
    Referència de l'ítem segons les normes APA: Bonet, Gil; Carrasquer, Anna; Peiro, Oscar M.; Sanchez-Gimenez, Raul; Lal-Trehan, Nisha; del-Moral-Ronda, Victor; Fort-Gallifa, Isabel; Bardaji, Alfre (2021). Clinical characteristics and prognostic implications of diabetes and myocardial injury in patients admitted to the emergency room. Bmc Cardiovascular Disorders, 21(1), 414-. DOI: 10.1186/s12872-021-02220-1
    DOI de l'article: 10.1186/s12872-021-02220-1
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2021
    Tipus de publicació: Journal Publications
  • Paraules clau:

    Cardiac & Cardiovascular Systems,Cardiology and Cardiovascular Medicine
    Type-2
    Troponin i
    Time factors
    Spain
    Risk factors
    Risk assessment
    Risk
    Retrospective studies
    Prognosis
    Prevention
    Patient readmission
    Patient admission
    Outcomes
    Myocardial injury
    Myocardial infarction
    Mortality
    Middle aged
    Mellitus
    Male
    Humans
    Heart failure
    Female
    Emergency service, hospital
    Disease progression
    Diabetes mellitus
    Diabetes
    Cardiovascular-disease
    Cardiac troponin-t
    Cardiac troponin
    Biomarkers
    Aged, 80 and over
    Aged
    Adults
    Saúde coletiva
    Psicología
    Medicina iii
    Medicina ii
    Medicina i
    Matemática / probabilidade e estatística
    Interdisciplinar
    Farmacia
    Educação física
    Ciências biológicas ii
    Ciências biológicas i
    Cardiology and cardiovascular medicine
    Cardiac & cardiovascular systems
    Biotecnología
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