Autor segons l'article: Canales-Rodriguez, Erick Jorge; Alonso-Lana, Silvia; Verdolini, Norma; Sarro, Salvador; Feria, Isabel; Montoro, Irene; Garcia-Ruiz, Beatriz; Jimenez, Esther; Varo, Cristina; Albacete, Auria; Argila-Plaza, Isabel; Lluch, Anna; Bonnin, C. Mar; Vilella, Elisabet; Vieta, Eduard; Pomarol-Clotet, Edith; Salvador, Raymond;
Departament: Medicina i Cirurgia
Autor/s de la URV: Vilella Cuadrada, Elisabet
Paraules clau: White-matter Voxel-based morphometry Tissue microstructure Sex-differences Myelin-water Myelin water fraction Multi-exponential relaxation Mri In-vivo Human corpus-callosum Gray-matter Diffusion-tensor Cortical thickness Brain Aging
Resum: In spite of extensive work, inconsistent findings and lack of specificity in most neuroimaging techniques used to examine age- and gender-related patterns in brain tissue microstructure indicate the need for additional research. Here, we performed the largest Multi-component T-2 relaxometry cross-sectional study to date in healthy adults (N = 145, 18-60 years). Five quantitative microstructure parameters derived from various segments of the estimated T-2 spectra were evaluated, allowing a more specific interpretation of results in terms of tissue microstructure. We found similar age-related myelin water fraction (MWF) patterns in men and women but we also observed differential male related results including increased MWF content in a few white matter tracts, a faster decline with age of the intra- and extra-cellular water fraction and its T-2 relaxation time (i.e. steeper age related negative slopes) and a faster increase in the free and quasi-free water fraction, spanning the whole grey matter. Such results point to a sexual dimorphism in brain tissue microstructure and suggest a lesser vulnerability to age-related changes in women. (C) 2021 The Author(s). Published by Elsevier Inc.
Àrees temàtiques: Saúde coletiva Psicología Neurosciences Neuroscience (miscellaneous) Neuroscience (all) Neurology (clinical) Medicina ii Medicina i Geriatrics and gerontology Geriatrics & gerontology General neuroscience Farmacia Enfermagem Developmental biology Ciências biológicas ii Ciências biológicas i Biotecnología Aging
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
Adreça de correu electrònic de l'autor: elisabet.vilella@urv.cat
Identificador de l'autor: 0000-0002-1887-5919
Data d'alta del registre: 2024-07-27
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
Enllaç font original: https://www.sciencedirect.com/science/article/pii/S0197458021001913
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: Neurobiology Of Aging. 106 68-79
Referència de l'ítem segons les normes APA: Canales-Rodriguez, Erick Jorge; Alonso-Lana, Silvia; Verdolini, Norma; Sarro, Salvador; Feria, Isabel; Montoro, Irene; Garcia-Ruiz, Beatriz; Jimenez, (2021). Age- and gender-related differences in brain tissue microstructure revealed by multi-component T-2 relaxometry. Neurobiology Of Aging, 106(), 68-79. DOI: 10.1016/j.neurobiolaging.2021.06.002
DOI de l'article: 10.1016/j.neurobiolaging.2021.06.002
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2021
Tipus de publicació: Journal Publications
Repositori URV