Articles producció científica> Medicina i Cirurgia

Age- and gender-related differences in brain tissue microstructure revealed by multi-component T-2 relaxometry

  • Datos identificativos

    Identificador: imarina:9227042
    Autores:
    Canales-Rodriguez, Erick JorgeAlonso-Lana, SilviaVerdolini, NormaSarro, SalvadorFeria, IsabelMontoro, IreneGarcia-Ruiz, BeatrizJimenez, EstherVaro, CristinaAlbacete, AuriaArgila-Plaza, IsabelLluch, AnnaBonnin, C. MarVilella, ElisabetVieta, EduardPomarol-Clotet, EdithSalvador, Raymond
    Resumen:
    In spite of extensive work, inconsistent findings and lack of specificity in most neuroimaging techniques used to examine age- and gender-related patterns in brain tissue microstructure indicate the need for additional research. Here, we performed the largest Multi-component T-2 relaxometry cross-sectional study to date in healthy adults (N = 145, 18-60 years). Five quantitative microstructure parameters derived from various segments of the estimated T-2 spectra were evaluated, allowing a more specific interpretation of results in terms of tissue microstructure. We found similar age-related myelin water fraction (MWF) patterns in men and women but we also observed differential male related results including increased MWF content in a few white matter tracts, a faster decline with age of the intra- and extra-cellular water fraction and its T-2 relaxation time (i.e. steeper age related negative slopes) and a faster increase in the free and quasi-free water fraction, spanning the whole grey matter. Such results point to a sexual dimorphism in brain tissue microstructure and suggest a lesser vulnerability to age-related changes in women. (C) 2021 The Author(s). Published by Elsevier Inc.
  • Otros:

    Autor según el artículo: Canales-Rodriguez, Erick Jorge; Alonso-Lana, Silvia; Verdolini, Norma; Sarro, Salvador; Feria, Isabel; Montoro, Irene; Garcia-Ruiz, Beatriz; Jimenez, Esther; Varo, Cristina; Albacete, Auria; Argila-Plaza, Isabel; Lluch, Anna; Bonnin, C. Mar; Vilella, Elisabet; Vieta, Eduard; Pomarol-Clotet, Edith; Salvador, Raymond;
    Departamento: Medicina i Cirurgia
    Autor/es de la URV: Vilella Cuadrada, Elisabet
    Palabras clave: White-matter Voxel-based morphometry Tissue microstructure Sex-differences Myelin-water Myelin water fraction Multi-exponential relaxation Mri In-vivo Human corpus-callosum Gray-matter Diffusion-tensor Cortical thickness Brain Aging
    Resumen: In spite of extensive work, inconsistent findings and lack of specificity in most neuroimaging techniques used to examine age- and gender-related patterns in brain tissue microstructure indicate the need for additional research. Here, we performed the largest Multi-component T-2 relaxometry cross-sectional study to date in healthy adults (N = 145, 18-60 years). Five quantitative microstructure parameters derived from various segments of the estimated T-2 spectra were evaluated, allowing a more specific interpretation of results in terms of tissue microstructure. We found similar age-related myelin water fraction (MWF) patterns in men and women but we also observed differential male related results including increased MWF content in a few white matter tracts, a faster decline with age of the intra- and extra-cellular water fraction and its T-2 relaxation time (i.e. steeper age related negative slopes) and a faster increase in the free and quasi-free water fraction, spanning the whole grey matter. Such results point to a sexual dimorphism in brain tissue microstructure and suggest a lesser vulnerability to age-related changes in women. (C) 2021 The Author(s). Published by Elsevier Inc.
    Áreas temáticas: Saúde coletiva Psicología Neurosciences Neuroscience (miscellaneous) Neuroscience (all) Neurology (clinical) Medicina ii Medicina i Geriatrics and gerontology Geriatrics & gerontology General neuroscience Farmacia Enfermagem Developmental biology Ciências biológicas ii Ciências biológicas i Biotecnología Aging
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    Direcció de correo del autor: elisabet.vilella@urv.cat
    Identificador del autor: 0000-0002-1887-5919
    Fecha de alta del registro: 2024-07-27
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    Enlace a la fuente original: https://www.sciencedirect.com/science/article/pii/S0197458021001913
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referencia al articulo segun fuente origial: Neurobiology Of Aging. 106 68-79
    Referencia de l'ítem segons les normes APA: Canales-Rodriguez, Erick Jorge; Alonso-Lana, Silvia; Verdolini, Norma; Sarro, Salvador; Feria, Isabel; Montoro, Irene; Garcia-Ruiz, Beatriz; Jimenez, (2021). Age- and gender-related differences in brain tissue microstructure revealed by multi-component T-2 relaxometry. Neurobiology Of Aging, 106(), 68-79. DOI: 10.1016/j.neurobiolaging.2021.06.002
    DOI del artículo: 10.1016/j.neurobiolaging.2021.06.002
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2021
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Aging,Developmental Biology,Geriatrics & Gerontology,Geriatrics and Gerontology,Neurology (Clinical),Neuroscience (Miscellaneous),Neurosciences
    White-matter
    Voxel-based morphometry
    Tissue microstructure
    Sex-differences
    Myelin-water
    Myelin water fraction
    Multi-exponential relaxation
    Mri
    In-vivo
    Human corpus-callosum
    Gray-matter
    Diffusion-tensor
    Cortical thickness
    Brain
    Aging
    Saúde coletiva
    Psicología
    Neurosciences
    Neuroscience (miscellaneous)
    Neuroscience (all)
    Neurology (clinical)
    Medicina ii
    Medicina i
    Geriatrics and gerontology
    Geriatrics & gerontology
    General neuroscience
    Farmacia
    Enfermagem
    Developmental biology
    Ciências biológicas ii
    Ciências biológicas i
    Biotecnología
    Aging
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