Articles producció científica> Enginyeria Electrònica, Elèctrica i Automàtica

Increased Hypothalamic Anti-Inflammatory Mediators in Non-Diabetic Insulin Receptor Substrate 2-Deficient Mice

  • Dades identificatives

    Identificador: imarina:9227050
    Autors:
    Vinaixa, MariaCanelles, SandraGonzalez-Murillo, AfricaFerreira, VitorGrajales, DianaGuerra-Cantera, SantiagoCampillo-Calatayud, AnaRamirez-Orellana, ManuelYanes, OscarFrago, Laura MValverde, Angela MBarrios, Vicente
    Resum:
    Insulin receptor substrate (IRS) 2 is a key mediator of insulin signaling and IRS-2 knockout (IRS2(-/-)) mice are a preclinical model to study the development of diabetes, as they develop peripheral insulin resistance and beta-cell failure. The differential inflammatory profile and insulin signaling in the hypothalamus of non-diabetic (ND) and diabetic (D) IRS2(-/-) mice might be implicated in the onset of diabetes. Because the lipid profile is related to changes in inflammation and insulin sensitivity, we analyzed whether ND IRS2(-/-) mice presented a different hypothalamic fatty acid metabolism and lipid pattern than D IRS2(-/-) mice and the relationship with inflammation and markers of insulin sensitivity. ND IRS2(-/-) mice showed elevated hypothalamic anti-inflammatory cytokines, while D IRS2(-/-) mice displayed a proinflammatory profile. The increased activity of enzymes related to the pentose-phosphate route and lipid anabolism and elevated polyunsaturated fatty acid levels were found in the hypothalamus of ND IRS2(-/-) mice. Conversely, D IRS2(-/-) mice have no changes in fatty acid composition, but hypothalamic energy balance and markers related to anti-inflammatory and insulin-sensitizing properties were reduced. The data suggest that the concurrence of an anti-inflammatory profile, increased insulin sensitivity and polyunsaturated fatty acids content in the hypothalamus may slow down or delay the onset of diabetes.
  • Altres:

    Autor segons l'article: Vinaixa, Maria; Canelles, Sandra; Gonzalez-Murillo, Africa; Ferreira, Vitor; Grajales, Diana; Guerra-Cantera, Santiago; Campillo-Calatayud, Ana; Ramirez-Orellana, Manuel; Yanes, Oscar; Frago, Laura M; Valverde, Angela M; Barrios, Vicente
    Departament: Enginyeria Electrònica, Elèctrica i Automàtica
    Autor/s de la URV: Vinaixa Crevillent, Maria / Yanes Torrado, Óscar
    Paraules clau: Sensitivity Pufa Pathway Pathogenesis Oxidative stress Obesity Modulation Mice, knockout Mice, inbred c57bl Mice Metabolism Lipid metabolism Leptin Irs2−/− mice Irs2 protein, mouse Irs2 Interleukin-1beta Insulin receptor substrate proteins Inhibition Inflammation Hypothalamus Glucose transport proteins, facilitative Fatty acids, unsaturated Expression Energy metabolism Diabetes mellitus, experimental Diabetes Cytokines Chemokine cx3cl1 Blood glucose Animals
    Resum: Insulin receptor substrate (IRS) 2 is a key mediator of insulin signaling and IRS-2 knockout (IRS2(-/-)) mice are a preclinical model to study the development of diabetes, as they develop peripheral insulin resistance and beta-cell failure. The differential inflammatory profile and insulin signaling in the hypothalamus of non-diabetic (ND) and diabetic (D) IRS2(-/-) mice might be implicated in the onset of diabetes. Because the lipid profile is related to changes in inflammation and insulin sensitivity, we analyzed whether ND IRS2(-/-) mice presented a different hypothalamic fatty acid metabolism and lipid pattern than D IRS2(-/-) mice and the relationship with inflammation and markers of insulin sensitivity. ND IRS2(-/-) mice showed elevated hypothalamic anti-inflammatory cytokines, while D IRS2(-/-) mice displayed a proinflammatory profile. The increased activity of enzymes related to the pentose-phosphate route and lipid anabolism and elevated polyunsaturated fatty acid levels were found in the hypothalamus of ND IRS2(-/-) mice. Conversely, D IRS2(-/-) mice have no changes in fatty acid composition, but hypothalamic energy balance and markers related to anti-inflammatory and insulin-sensitizing properties were reduced. The data suggest that the concurrence of an anti-inflammatory profile, increased insulin sensitivity and polyunsaturated fatty acids content in the hypothalamus may slow down or delay the onset of diabetes.
    Àrees temàtiques: Medicine (miscellaneous) Cell biology Biochemistry, genetics and molecular biology (miscellaneous) Biochemistry, genetics and molecular biology (all)
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    Adreça de correu electrònic de l'autor: maria.vinaixa@urv.cat oscar.yanes@urv.cat maria.vinaixa@urv.cat
    Identificador de l'autor: 0000-0001-9804-0171 0000-0003-3695-7157 0000-0001-9804-0171
    Data d'alta del registre: 2024-10-12
    Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
    Enllaç font original: https://www.mdpi.com/2073-4409/10/8/2085
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referència a l'article segons font original: Cells. 10 (8): 2085-
    Referència de l'ítem segons les normes APA: Vinaixa, Maria; Canelles, Sandra; Gonzalez-Murillo, Africa; Ferreira, Vitor; Grajales, Diana; Guerra-Cantera, Santiago; Campillo-Calatayud, Ana; Ramir (2021). Increased Hypothalamic Anti-Inflammatory Mediators in Non-Diabetic Insulin Receptor Substrate 2-Deficient Mice. Cells, 10(8), 2085-. DOI: 10.3390/cells10082085
    DOI de l'article: 10.3390/cells10082085
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2021
    Tipus de publicació: Journal Publications
  • Paraules clau:

    Biochemistry, Genetics and Molecular Biology (Miscellaneous),Cell Biology,Medicine (Miscellaneous)
    Sensitivity
    Pufa
    Pathway
    Pathogenesis
    Oxidative stress
    Obesity
    Modulation
    Mice, knockout
    Mice, inbred c57bl
    Mice
    Metabolism
    Lipid metabolism
    Leptin
    Irs2−/− mice
    Irs2 protein, mouse
    Irs2
    Interleukin-1beta
    Insulin receptor substrate proteins
    Inhibition
    Inflammation
    Hypothalamus
    Glucose transport proteins, facilitative
    Fatty acids, unsaturated
    Expression
    Energy metabolism
    Diabetes mellitus, experimental
    Diabetes
    Cytokines
    Chemokine cx3cl1
    Blood glucose
    Animals
    Medicine (miscellaneous)
    Cell biology
    Biochemistry, genetics and molecular biology (miscellaneous)
    Biochemistry, genetics and molecular biology (all)
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