Lligands tioèter-carbè N-heterocíclics per a la hidrogenació asimètrica dolefines: perspectiva i oportunitats

Identificador:  imarina:9230001

Handle: https://hdl.handle.net/20.500.11797/imarina9230001

Autors:  Pol de la Cruz Sánchez; Oscar Pàmies; Montserrat Diéguez Fernández

Resum:
Asymmetric catalysis has emerged as one of the most powerful tools for the synthesis of high value organic com- pounds (i.e. pharmaceuticals, fragrances, agrochemicals, etc.). In this field, the asymmetric hydrogenation (AH) of olefins is one of the most sustainable methods due to its perfect atomic economy, high efficiency and operational simplicity. Phosphine ligands have dominated the field of asymmetric hydrogenation during the past decades, but the recent success of thioether- based ligands (developed in our group) and carbene-based ligands make these scaffolds an ideal field for further investi-gations. In this case, we decided to combine these two scaffolds with the preparation of new thioether-carbene ligands and compare their efficiency in the AH of olefins with their phosphorus-based analogues, together with mechanistic studies (reactivities with deuterium and hydrogen).