Autor segons l'article: Laguna, Juan C.; Alegret, Marta; Cofan, Montserrat; Sanchez-Tainta, Ana; Diaz-Lopez, Andres; Martinez-Gonzalez, Miguel A.; V. Sorli, Jose; Salas-Salvado, Jordi; Fito, Montserrat; Alonso-Gomez, Angel M.; Serra-Majem, Lluis; Laperra, Jose; Fiol, Miquel; Gomez-Gracia, Enrique; Pinto, Xavier; Munoz, Miguel A.; Castaner, Olga; Ramirez-Sabio, Judith B.; Portu, Jose J.; Estruch, Ramon; Ros, Emilio;
Departament: Ciències Mèdiques Bàsiques Bioquímica i Biotecnologia
Autor/s de la URV: Díaz López, Andres / Salas Salvadó, Jorge
Paraules clau: Sweetened beverages Sugar-sweetened beverage Sugar intake Risk Randomized controlled trial Prospective study Prevalence Population Physical-activity questionnaire Patient participation Pancreatic-cancer Observational study Obesity Multicenter study Male Major clinical study Liquid form Human High risk population Groups by age Glycemic index Glucose intake Glucose Fruit juice Fructose intake Fructose Follow up Female Dietary sugar Diabetes-mellitus Diabetes mellitus Controlled study Consumption Cohort analysis Cardiovascular risk Cardiovascular disease Cancer risk Cancer mortality Cancer incidence Body-mass index Article All cause mortality Aged
Resum: Objective: To examine associations between intake of simple sugars and cancer incidence, cancer mor-tality, and total mortality in a prospective cohort study based on the PREDIMED trial conducted from 2003 to 2010. Methods: Participants were older individuals at high cardiovascular risk. Exposures were total sugar, glucose and fructose from solid or liquid sources, and fructose from fruit and 100% fruit juice. Cancer incidence was the primary outcome; cancer mortality and all-cause mortality were secondary outcomes. Multivariable-adjusted, time-dependent Cox proportional hazard models were used. Results: Of 7447 individuals enrolled, 7056 (94.7%) were included (57.6% women, aged 67.0 +/- 6.2 years). 534 incident cancers with 152 cancer deaths and 409 all-cause deaths were recorded after a median follow-up of 6 years. Intake of simple sugars in solid form was unrelated to outcomes. Higher cancer incidence was found per 5 g/day increase in intake of liquid sugars, with multivariable-adjusted HR of 1.08 (95% CI, 1.03-1.13) for total liquid sugar, 1.19 (95% CI, 1.07-1.31) for liquid glucose, 1.14 (95% CI, 1.05-1.23) for liquid fructose, and 1.39 (95% CI, 1.10-1.74) for fructose from fruit juice. Cancer and all-cause mortality increased to a similar extent with intake of all sugars in liquid form. In categorical models, cancer risk was dose-related for all liquid sugars. Conclusions: Simple sugar intake in drinks and fruit juice was associated with an increased risk of overall cancer incidence and mortality and all-cause mortality. This suggests that sugary beverages are a modifiable risk factor for cancer and all-cause mortality. (c) 2021 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Àrees temàtiques: Saúde coletiva Química Odontología Nutrition and dietetics Nutrition & dietetics Nutrição Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Farmacia Engenharias iv Enfermagem Educação física Critical care and intensive care medicine Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciência de alimentos Biotecnología
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
Adreça de correu electrònic de l'autor: andres.diaz@urv.cat jordi.salas@urv.cat
Identificador de l'autor: 0000-0002-7500-5629 0000-0003-2700-7459
Data d'alta del registre: 2024-07-27
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: Clinical Nutrition. 40 (10): 5269-5277
Referència de l'ítem segons les normes APA: Laguna, Juan C.; Alegret, Marta; Cofan, Montserrat; Sanchez-Tainta, Ana; Diaz-Lopez, Andres; Martinez-Gonzalez, Miguel A.; V. Sorli, Jose; Salas-Salva (2021). Simple sugar intake and cancer incidence, cancer mortality and all- cause mortality: A cohort study from the PREDIMED trial. Clinical Nutrition, 40(10), 5269-5277. DOI: 10.1016/j.clnu.2021.07.031
DOI de l'article: 10.1016/j.clnu.2021.07.031
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2021
Tipus de publicació: Journal Publications
Repositori URV