Inflammatory potential of diet and bone mineral density in a senior Mediterranean population: a cross-sectional analysis of PREDIMED-Plus study

Autor segons l'article: Garcia-Gavilan, Jesus F; Paz-Graniel, Indira; Babio, Nancy; Romaguera, Dora; Alfredo Martinez, Jose; Martin, Vicente; Angeles Martinez, Maria; Konieczna, Jadwiga; Ruiz-Canela, Miguel; de Paz Fernandez, Jose Antonio; Goday, Albert; Angel Martinez-Gonzalez, Miguel; Bullo, Monica; Salas-Salvado, Jordi

Departament: Bioquímica i Biotecnologia

Autor/s de la URV: Babio Sánchez, Nancy Elvira / Bulló Bonet, Mònica / García Gavilán, Jesús Francisco / Martínez Rodríguez, María Ángeles / Paz Graniel, Indira del Socorro / Salas Salvadó, Jorge

Paraules clau: Osteoporosis; Middle aged; Inflammation; Humans; Diet; Cross-sectional studies; Bone mineral density; Bone density; Aged; Absorptiometry, photon

Resum: Purpose: Inflammation could play a key role in tissue damage and bone metabolism. The modified dietary inflammatory score (M-DIS) is a validated tool to estimate the inflammatory potential of the diet. In the present study, we evaluate the associations between the M-DIS and bone mineral density (BMD) in a senior Mediterranean population with overweight/obesity and metabolic syndrome. Methods: Baseline cross-sectional association between the M-DIS and bone mineral density was assessed in 1134 participants of the multicenter PREDIMED-Plus trial (aged 55–75 with overweight/obesity and metabolic syndrome). BMD was measured using Dual-energy X-ray Absorptiometry scans and participants answered a food frequency questionnaire to determine the M-DIS. BMD was categorized as low BMD when T score was equal or lower than -1 and normal BMD in another case. Associations between BMD and M-DIS were evaluated by using linear and logistic regressions adjusted by other co-variates. Results: Participants in the top tertile of the M-DIS had a lower BMD at total femur [? (95% CI) ? 0.02 (? 0.04, ? 0.01)], trochanter areas [? (95% CI) ? 0.03 (? 0.05, ? 0.01)] and lumbar spine area [? (95% CI) ? 0.03 (? 0.07, 0.01)] (but in the last case, measures were less precise and hence not statistically significant) compared to those in the lower M-DIS tertile. Multiple logistic regression analyses showed that the odds of the total femur and femoral trochanter osteopenia/osteoporosis were higher in participants in the top tertile compared to those in the lowest tertile of M-DIS [OR (95% CI) 1.71 (1.12, 2.64), P for trend 0.015; 2.02 (1.29, 3.21), P for trend 0.002, respectively]. Conclusion: A high pro-inflammatory diet, measured by the M-DIS, is associated with lower BMD in a senior Mediterranean population with metabolic syndrome. © 2021, The Author(s).

Àrees temàtiques: Serviço social; Saúde coletiva; Química; Nutrition and dietetics; Nutrition & dietetics; Nutrição; Medicine (miscellaneous); Medicina veterinaria; Medicina iii; Medicina ii; Medicina i; Interdisciplinar; Farmacia; Educação física; Ciências biológicas iii; Ciências biológicas ii; Ciências biológicas i; Ciências ambientais; Ciências agrárias i; Ciência de alimentos

Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/

Adreça de correu electrònic de l'autor: jesusfrancisco.garcia@urv.cat; indiradelsocorro.paz@urv.cat; mangeles.martinez@urv.cat; jesusfrancisco.garcia@urv.cat; indiradelsocorro.paz@urv.cat; monica.bullo@urv.cat; jordi.salas@urv.cat; nancy.babio@urv.cat

Data d'alta del registre: 2025-02-18

Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion

Enllaç font original: https://pubmed.ncbi.nlm.nih.gov/34842966/

URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/

Referència a l'article segons font original: European Journal Of Nutrition. 61 (3): 1445-1455

Referència de l'ítem segons les normes APA: Garcia-Gavilan, Jesus F; Paz-Graniel, Indira; Babio, Nancy; Romaguera, Dora; Alfredo Martinez, Jose; Martin, Vicente; Angeles Martinez, Maria; Koniecz (2022). Inflammatory potential of diet and bone mineral density in a senior Mediterranean population: a cross-sectional analysis of PREDIMED-Plus study. European Journal Of Nutrition, 61(3), 1445-1455. DOI: 10.1007/s00394-021-02751-5

DOI de l'article: 10.1007/s00394-021-02751-5

Entitat: Universitat Rovira i Virgili

Any de publicació de la revista: 2022

Tipus de publicació: Journal Publications