Articles producció científica> Ciències Mèdiques Bàsiques

Prenatal folic acid supplementation and folate status in early pregnancy: ECLIPSES study

  • Dades identificatives

    Identificador: imarina:9242308
    Autors:
    Iglesias-Vázquez LSerrat NBedmar CPallejà-Millán MArija V
    Resum:
    This research evaluates the prevalence of inadequate folate status in early pregnancy, the pattern of prenatal folic acid (FA) supplementation and associated factors in Spanish pregnant women from the ECLIPSES study, which included 791 participants prior gestational week 12. A cross-sectional evaluation of red blood cell (RBC) folate levels was performed at recruitment and used to calculate the prevalence of folate deficiency (RBC folate<340 nmol/L) and insufficiency (RBC folate<906 nmol/L). Sociodemographic and lifestyle data, as well as information on prenatal FA supplementation were recorded. Descriptive and multivariate statistical analyses were performed. The prevalence of folate deficiency and insufficiency were 9.6% and 86.5%, respectively. Most of women used prenatal FA supplements but only 6.3% did so as recommended. Supplementation with FA during the periconceptional period abolished folate deficiency and reduced folate insufficiency. Prenatal folic acid supplementation with ?1000 ?g/d in periconceptional time and pregnancy planning increased RBC folate levels. The main risk factor for folate insufficiency in early pregnancy were getting prenatal FA supplementation out of the periconceptional time (OR 3.32, 95%CI 1.02-15.36), while for folate deficiency they were young age (OR 2.02, 95%CI 1.05-3.99), and smoking (OR 2.39, 95%CI 1.30-4.37). In addition, social and ethnic differences according to folate status were also identified. As conclusion, periconceptional FA use is crucial for achieving optimal folate levels in early pregnancy. Pregnancy planning should focus on young women, smokers, those with low consumption of folate-rich foods, low socioeconomic status or from ethnic minorities. © The Authors 2021.
  • Altres:

    Autor segons l'article: Iglesias-Vázquez L; Serrat N; Bedmar C; Pallejà-Millán M; Arija V
    Departament: Ciències Mèdiques Bàsiques
    Autor/s de la URV: Arija Val, Maria Victoria / Bedmar Carretero, Cristina / Iglesias Vazquez, Lucia
    Paraules clau: Supplementation Prenatal care Pregnancy planning Neural-tube defects Keywords: Folic acid Folate Eclipses study women vitamin-b-12 deficiencies survival supplementation prenatal care pregnancy planning population infant health folate eclipses study diet determinants brain-development
    Resum: This research evaluates the prevalence of inadequate folate status in early pregnancy, the pattern of prenatal folic acid (FA) supplementation and associated factors in Spanish pregnant women from the ECLIPSES study, which included 791 participants prior gestational week 12. A cross-sectional evaluation of red blood cell (RBC) folate levels was performed at recruitment and used to calculate the prevalence of folate deficiency (RBC folate<340 nmol/L) and insufficiency (RBC folate<906 nmol/L). Sociodemographic and lifestyle data, as well as information on prenatal FA supplementation were recorded. Descriptive and multivariate statistical analyses were performed. The prevalence of folate deficiency and insufficiency were 9.6% and 86.5%, respectively. Most of women used prenatal FA supplements but only 6.3% did so as recommended. Supplementation with FA during the periconceptional period abolished folate deficiency and reduced folate insufficiency. Prenatal folic acid supplementation with ?1000 ?g/d in periconceptional time and pregnancy planning increased RBC folate levels. The main risk factor for folate insufficiency in early pregnancy were getting prenatal FA supplementation out of the periconceptional time (OR 3.32, 95%CI 1.02-15.36), while for folate deficiency they were young age (OR 2.02, 95%CI 1.05-3.99), and smoking (OR 2.39, 95%CI 1.30-4.37). In addition, social and ethnic differences according to folate status were also identified. As conclusion, periconceptional FA use is crucial for achieving optimal folate levels in early pregnancy. Pregnancy planning should focus on young women, smokers, those with low consumption of folate-rich foods, low socioeconomic status or from ethnic minorities. © The Authors 2021.
    Àrees temàtiques: Zootecnia / recursos pesqueiros Saúde coletiva Química Odontología Nutrition and dietetics Nutrition & dietetics Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Matemática / probabilidade e estatística Interdisciplinar General medicine Farmacia Engenharias iv Engenharias ii Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Administração pública e de empresas, ciências contábeis e turismo
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    Adreça de correu electrònic de l'autor: cristina.bedmar@urv.cat lucia.iglesias@urv.cat victoria.arija@urv.cat
    Identificador de l'autor: 0000-0001-7131-4144 0000-0002-1758-0975
    Data d'alta del registre: 2024-09-07
    Versió de l'article dipositat: info:eu-repo/semantics/acceptedVersion
    Enllaç font original: https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/abs/prenatal-folic-acid-supplementation-and-folate-status-in-early-pregnancy-eclipses-study/DFCFF4C62A67CFCBE968ADEA4EBC3532
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referència a l'article segons font original: British Journal Of Nutrition. 128 (10): 1938-1945
    Referència de l'ítem segons les normes APA: Iglesias-Vázquez L; Serrat N; Bedmar C; Pallejà-Millán M; Arija V (2022). Prenatal folic acid supplementation and folate status in early pregnancy: ECLIPSES study. British Journal Of Nutrition, 128(10), 1938-1945. DOI: 10.1017/s0007114521004840
    DOI de l'article: 10.1017/s0007114521004840
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2022
    Tipus de publicació: Journal Publications
  • Paraules clau:

    Medicine (Miscellaneous),Nutrition & Dietetics,Nutrition and Dietetics
    Supplementation
    Prenatal care
    Pregnancy planning
    Neural-tube defects
    Keywords:
    Folic acid
    Folate
    Eclipses study
    women
    vitamin-b-12 deficiencies
    survival
    supplementation
    prenatal care
    pregnancy planning
    population
    infant
    health
    folate
    eclipses study
    diet
    determinants
    brain-development
    Zootecnia / recursos pesqueiros
    Saúde coletiva
    Química
    Odontología
    Nutrition and dietetics
    Nutrition & dietetics
    Nutrição
    Medicine (miscellaneous)
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Matemática / probabilidade e estatística
    Interdisciplinar
    General medicine
    Farmacia
    Engenharias iv
    Engenharias ii
    Educação física
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência de alimentos
    Biotecnología
    Biodiversidade
    Administração pública e de empresas, ciências contábeis e turismo
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