Autor segons l'article: Balaguer-Trias J; Deepika D; Schuhmacher M; Kumar V
Departament: Enginyeria Química
Autor/s de la URV: Balaguer Trias, Jordina / Kumar, Vikas / Schuhmacher Ansuategui, Marta
Paraules clau: Pfas Neurotoxicity In-vivo In-silico Gut microbiota Dehp Chlorpyrifos Bpa Bisphenol-a system risk pfas neurotoxicity metabolism maturation in-silico health gut microbiota diet dehp chlorpyrifos bpa
Resum: Over the last years, research has focused on microbiota to establish a missing link between neuronal health and intestine imbalance. Many studies have considered microbiota as critical regulators of the gut–brain axis. The crosstalk between microbiota and the central nervous system is mainly explained through three different pathways: the neural, endocrine, and immune pathways, intricately interconnected with each other. In day-to-day life, human beings are exposed to a wide variety of contaminants that affect our intestinal microbiota and alter the bidirectional communication between the gut and brain, causing neuronal disorders. The interplay between xenobiotics, microbiota and neurotoxicity is still not fully explored, especially for susceptible populations such as pregnant women, neonates, and developing children. Precisely, early exposure to contaminants can trigger neurodevelopmental toxicity and long-term diseases. There is growing but limited research on the specific mechanisms of the microbiota–gut–brain axis (MGBA), making it challenging to understand the effect of environmental pollutants. In this review, we discuss the biological interplay between microbiota–gut–brain and analyse the role of endocrine-disrupting chemicals: Bisphenol A (BPA), Chlorpyrifos (CPF), Diethylhexyl phthalate (DEHP), and Per-and polyfluoroalkyl substances (PFAS) in MGBA perturbations and subsequent neurotoxicity. The complexity of the MGBA and the changing nature of the gut microbiota pose significant challenges for future research. However, emerging in-silico models able to analyse and interpret meta-omics data are a promising option for understanding the processes in this axis and can help prevent neurotoxicity.
Àrees temàtiques: Zootecnia / recursos pesqueiros Serviço social Saúde coletiva Química Public, environmental & occupational health Public health, environmental and occupational health Psicología Pollution Odontología Nutrição Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Health, toxicology and mutagenesis Geografía Geociências Farmacia Environmental studies Environmental sciences Ensino Engenharias ii Engenharias i Enfermagem Educação física Educação Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência da computação Biotecnología Biodiversidade Astronomia / física Administração pública e de empresas, ciências contábeis e turismo
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
Adreça de correu electrònic de l'autor: vikas.kumar@urv.cat marta.schuhmacher@urv.cat jordina.balaguer@estudiants.urv.cat jordina.balaguer@estudiants.urv.cat
Identificador de l'autor: 0000-0002-9795-5967 0000-0003-4381-2490 0000-0001-9001-207X 0000-0001-9001-207X
Data d'alta del registre: 2024-06-15
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
Enllaç font original: https://www.mdpi.com/1660-4601/19/3/1368
URL Document de llicència: http://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: International Journal Of Environmental Research And Public Health. 19 (3):
Referència de l'ítem segons les normes APA: Balaguer-Trias J; Deepika D; Schuhmacher M; Kumar V (2022). Impact of Contaminants on Microbiota: Linking the Gut–Brain Axis with Neurotoxicity. International Journal Of Environmental Research And Public Health, 19(3), -. DOI: 10.3390/ijerph19031368
DOI de l'article: 10.3390/ijerph19031368
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2022
Tipus de publicació: Journal Publications
Repositori URV