Autor segons l'article: Moral A; Borrull F; Furton KG; Kabir A; Fontanals N; Marcé RM
Departament: Química Analítica i Química Orgànica
Autor/s de la URV: Fontanals Torroja, Núria / Marcé Recasens, Rosa Maria
Paraules clau: Solid-phase extraction Silica sorbents Mixed-mode zwitterionic sorbents Environmental samples Basic compounds
Resum: Four novel mixed-mode zwitterionic silica-based functionalized with strong moieties sorbents were synthesized and evaluated through solid-phase extraction (SPE) to determine acidic and basic drugs in environmental water samples. All sorbents had the same functionalization: quaternary amine and sulfonic groups and C18 chains so that hydrophobic and strong cationic exchange (SCX) and strong anionic exchange (SAX) interactions could be exploited, in addition, two of them had carbon microparticles embedded. All sorbents retained both acidic and basic compounds in the preliminary assays but only the basic compounds were retained selectively through ionic exchange interactions when a clean-up step was introduced. The SPE method was therefore optimized to promote the selective retention of the basic compounds, initially with the two best-performing sorbents. After optimization of the SPE protocol, these sorbents were evaluated for the analysis of environmental water samples using liquid chromatography-tandem mass spectrometry (LC-MS/MS). The method with the best-performing sorbent was then validated with 100 mL of river samples and 50 mL of effluent wastewater samples in terms of apparent recoveries (%Rapp) spiking samples at 50 ng/L (river) and 200 ng/L (river and effluent), matrix effect, linear range, method quantification and detection limits, repeatability, and reproducibility. It should be highlighted that %Rapp ranged from 40 to 85% and matrix effects ranged from -17 to -4% for spiked river samples. When the method was applied to river and effluent wastewater samples, most compounds were found in the range from 24 to 1233 ng/L with detection limits from 1 to 5 ng/L.
Àrees temàtiques: Zootecnia / recursos pesqueiros Química Organic chemistry Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina ii Medicina i Materiais Interdisciplinar Geociências General medicine Farmacia Engenharias ii Engenharias i Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Chemistry, analytical Biotecnología Biodiversidade Biochemistry Biochemical research methods Analytical chemistry
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
Adreça de correu electrònic de l'autor: nuria.fontanals@urv.cat rosamaria.marce@urv.cat nuria.fontanals@urv.cat
Identificador de l'autor: 0000-0002-7534-1964 0000-0002-5667-2899 0000-0002-7534-1964
Data d'alta del registre: 2023-02-23
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
Enllaç font original: https://www.sciencedirect.com/science/article/pii/S0021967322004307
URL Document de llicència: http://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: Journal Of Chromatography a. 1676 463237-
Referència de l'ítem segons les normes APA: Moral A; Borrull F; Furton KG; Kabir A; Fontanals N; Marcé RM (2022). Development of sol-gel silica-based mixed-mode zwitterionic sorbents for determining drugs in environmental water samples. Journal Of Chromatography a, 1676(), 463237-. DOI: 10.1016/j.chroma.2022.463237
DOI de l'article: 10.1016/j.chroma.2022.463237
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2022
Tipus de publicació: Journal Publications
Repositori URV