Autor segons l'article: Masip, Jenifer; Jorba, Rosa; Lopez-Dupla, Miguel; Domingo, Pere; Maria Pacheco, Yolanda; Garcia-Pardo, Graciano; Martinez, Esteban; Vilades, Consuelo; Veloso, Sergi; Alba, Veronica; Olona, Montserrat; Vidal, Francesc; Gomez-Bertomeu, Frederic; Peraire, Joaquim; Rull, Anna;
Departament: Medicina i Cirurgia
Autor/s de la URV: Garcia Pardo, Graciano / Gomez Bertomeu, Frederic-Francesc / Jorba Martin, Rosa Maria / López Dupla, Jesús Miguel / Masip Morcillo, Jenifer / Olona Cabases, Maria Montserrat / Peraire Forner, José Joaquin / RULL AIXA, ANNA / Veloso Esteban, Sergio / Vidal Marsal, Francisco / Vilades Laborda, Consuelo Gloria
Paraules clau: Risk-factor People living with hiv Nuclear magnetic resonance Longitudinal analysis Lipoproteins Immunological non-responder Hiv Cardiovascular-disease Cardiovascular risk Atherosclerosis Antiretroviral therapy
Resum: Nuclear magnetic resonance (NMR)-based advanced lipoprotein tests have demonstrated that LDL and HDL particle numbers (LDL-P and HDL-P) are more powerful cardiovascular (CV) risk biomarkers than conventional cholesterol markers. Of interest, in people living with HIV (PLHIV), predictors of preclinical atherosclerosis and vascular dysfunction may be associated with impaired immune function. We previously stated that immunological non-responders (INR) were at higher CV risk than immunological responders (IR) before starting antiretroviral therapy (ART). Using Liposcale (R) tests, we characterized the lipoprotein profile from the same cohort of PLHIV at month 12 and month 36 after starting ART, intending to explore what happened with these indicators of CV risk during viral suppression. ART initiation dissipates the differences in lipoprotein-based CV risk markers between INR and IR, and only an increase in the number of HDL-P was found in INR + IR when compared to controls (p = 0.047). Interestingly, CD4(+) T-cell counts negatively correlated with medium HDL-P concentrations at month 12 in all individuals (p = -0.335, p = 0.003). Longitudinal analyses showed an important increase in LDL-P and HDL-P at month 36 when compared to baseline values in both IR and INR. A proper balance between a proatherogenic and atherogenic environment may be related to the reconstitution of CD4(+) T-cell count in PLHIV.
Àrees temàtiques: Zootecnia / recursos pesqueiros Spectroscopy Saúde coletiva Química Psicología Physical and theoretical chemistry Organic chemistry Odontología Nutrição Molecular biology Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Inorganic chemistry Geociências Farmacia Engenharias iv Engenharias ii Engenharias i Educação física Computer science applications Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Chemistry, multidisciplinary Catalysis Biotecnología Biodiversidade Biochemistry & molecular biology Astronomia / física
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
Adreça de correu electrònic de l'autor: graciano.garcia@urv.cat sergio.veloso@urv.cat frederic-francesc.gomez@urv.cat joaquim.peraire@urv.cat consuelo.vilades@urv.cat jenifer.masip@estudiants.urv.cat jenifer.masip@estudiants.urv.cat rosamaria.jorba@urv.cat francesc.vidal@urv.cat jesusmiguel.lopez@urv.cat
Identificador de l'autor: 0000-0002-8039-2889 0000-0001-7808-5479 0000-0002-2991-9593 0000-0003-3307-4340 0000-0002-6692-6186 0000-0002-9141-2523
Data d'alta del registre: 2024-09-07
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
Enllaç font original: https://www.mdpi.com/1422-0067/23/15/8071
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: International Journal Of Molecular Sciences. 23 (15):
Referència de l'ítem segons les normes APA: Masip, Jenifer; Jorba, Rosa; Lopez-Dupla, Miguel; Domingo, Pere; Maria Pacheco, Yolanda; Garcia-Pardo, Graciano; Martinez, Esteban; Vilades, Consuelo; (2022). Lipoprotein Profile in Immunological Non-Responders PLHIV after Antiretroviral Therapy Initiation. International Journal Of Molecular Sciences, 23(15), -. DOI: 10.3390/ijms23158071
DOI de l'article: 10.3390/ijms23158071
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2022
Tipus de publicació: Journal Publications