Articles producció científica> Medicina i Cirurgia

Lipoprotein Profile in Immunological Non-Responders PLHIV after Antiretroviral Therapy Initiation

  • Identification data

    Identifier: imarina:9280708
  • Authors:

    Masip, Jenifer
    Jorba, Rosa
    Lopez-Dupla, Miguel
    Domingo, Pere
    Maria Pacheco, Yolanda
    Garcia-Pardo, Graciano
    Martinez, Esteban
    Vilades, Consuelo
    Veloso, Sergi
    Alba, Veronica
    Olona, Montserrat
    Vidal, Francesc
    Gomez-Bertomeu, Frederic
    Peraire, Joaquim
    Rull, Anna
  • Others:

    Author, as appears in the article.: Masip, Jenifer; Jorba, Rosa; Lopez-Dupla, Miguel; Domingo, Pere; Maria Pacheco, Yolanda; Garcia-Pardo, Graciano; Martinez, Esteban; Vilades, Consuelo; Veloso, Sergi; Alba, Veronica; Olona, Montserrat; Vidal, Francesc; Gomez-Bertomeu, Frederic; Peraire, Joaquim; Rull, Anna;
    Department: Medicina i Cirurgia
    URV's Author/s: Garcia Pardo, Graciano / Gomez Bertomeu, Frederic-Francesc / Jorba Martin, Rosa Maria / López Dupla, Jesús Miguel / Masip Morcillo, Jenifer / Olona Cabases, Maria Montserrat / Peraire Forner, José Joaquin / RULL AIXA, ANNA / Veloso Esteban, Sergio / Vidal Marsal, Francisco / Vilades Laborda, Consuelo Gloria
    Keywords: Risk-factor People living with hiv Nuclear magnetic resonance Longitudinal analysis Lipoproteins Immunological non-responder Hiv Cardiovascular-disease Cardiovascular risk Atherosclerosis Antiretroviral therapy
    Abstract: Nuclear magnetic resonance (NMR)-based advanced lipoprotein tests have demonstrated that LDL and HDL particle numbers (LDL-P and HDL-P) are more powerful cardiovascular (CV) risk biomarkers than conventional cholesterol markers. Of interest, in people living with HIV (PLHIV), predictors of preclinical atherosclerosis and vascular dysfunction may be associated with impaired immune function. We previously stated that immunological non-responders (INR) were at higher CV risk than immunological responders (IR) before starting antiretroviral therapy (ART). Using Liposcale (R) tests, we characterized the lipoprotein profile from the same cohort of PLHIV at month 12 and month 36 after starting ART, intending to explore what happened with these indicators of CV risk during viral suppression. ART initiation dissipates the differences in lipoprotein-based CV risk markers between INR and IR, and only an increase in the number of HDL-P was found in INR + IR when compared to controls (p = 0.047). Interestingly, CD4(+) T-cell counts negatively correlated with medium HDL-P concentrations at month 12 in all individuals (p = -0.335, p = 0.003). Longitudinal analyses showed an important increase in LDL-P and HDL-P at month 36 when compared to baseline values in both IR and INR. A proper balance between a proatherogenic and atherogenic environment may be related to the reconstitution of CD4(+) T-cell count in PLHIV.
    Thematic Areas: Zootecnia / recursos pesqueiros Spectroscopy Saúde coletiva Química Psicología Physical and theoretical chemistry Organic chemistry Odontología Nutrição Molecular biology Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Inorganic chemistry Geociências Farmacia Engenharias iv Engenharias ii Engenharias i Educação física Computer science applications Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Chemistry, multidisciplinary Catalysis Biotecnología Biodiversidade Biochemistry & molecular biology Astronomia / física
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: graciano.garcia@urv.cat mariamontserrat.olona@urv.cat rosamaria.jorba@urv.cat sergio.veloso@urv.cat frederic-francesc.gomez@urv.cat joaquim.peraire@urv.cat consuelo.vilades@urv.cat jesusmiguel.lopez@urv.cat francesc.vidal@urv.cat jenifer.masip@estudiants.urv.cat jenifer.masip@estudiants.urv.cat
    Author identifier: 0000-0003-3307-4340 0000-0002-8039-2889 0000-0001-7808-5479 0000-0002-2991-9593 0000-0002-9141-2523 0000-0002-6692-6186
    Record's date: 2024-02-25
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.mdpi.com/1422-0067/23/15/8071
    Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: International Journal Of Molecular Sciences. 23 (15):
    APA: Masip, Jenifer; Jorba, Rosa; Lopez-Dupla, Miguel; Domingo, Pere; Maria Pacheco, Yolanda; Garcia-Pardo, Graciano; Martinez, Esteban; Vilades, Consuelo; (2022). Lipoprotein Profile in Immunological Non-Responders PLHIV after Antiretroviral Therapy Initiation. International Journal Of Molecular Sciences, 23(15), -. DOI: 10.3390/ijms23158071
    Article's DOI: 10.3390/ijms23158071
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2022
    Publication Type: Journal Publications
  • Keywords:

    Biochemistry & Molecular Biology,Catalysis,Chemistry, Multidisciplinary,Computer Science Applications,Inorganic Chemistry,Medicine (Miscellaneous),Molecular Biology,Organic Chemistry,Physical and Theoretical Chemistry,Spectroscopy
    Risk-factor
    People living with hiv
    Nuclear magnetic resonance
    Longitudinal analysis
    Lipoproteins
    Immunological non-responder
    Hiv
    Cardiovascular-disease
    Cardiovascular risk
    Atherosclerosis
    Antiretroviral therapy
    Zootecnia / recursos pesqueiros
    Spectroscopy
    Saúde coletiva
    Química
    Psicología
    Physical and theoretical chemistry
    Organic chemistry
    Odontología
    Nutrição
    Molecular biology
    Medicine (miscellaneous)
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Materiais
    Interdisciplinar
    Inorganic chemistry
    Geociências
    Farmacia
    Engenharias iv
    Engenharias ii
    Engenharias i
    Educação física
    Computer science applications
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência de alimentos
    Ciência da computação
    Chemistry, multidisciplinary
    Catalysis
    Biotecnología
    Biodiversidade
    Biochemistry & molecular biology
    Astronomia / física
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