Autor segons l'article: Bazellieres, Elsa; Conte, Vito; Elosegui-Artola, Alberto; Serra-Picamal, Xavier; Bintanel-Morcillo, Maria; Roca-Cusachs, Pere; Munoz, Jose J; Sales-Pardo, Marta; Guimera, Roger; Trepat, Xavier
Departament: Enginyeria Química
Autor/s de la URV: Guimera Manrique, Roger / Sales Pardo, Marta
Paraules clau: Vinculin Vcl protein, human Uvomorulin Unclassified drug Small interfering rna Rna, small interfering Rna interference Regulatory mechanism Protein function Protein analysis Priority journal Physiology Phenotype P cadherin Monolayer culture Metabolism Mechanotransduction, cellular Mechanotransduction Mechanical stress Mcf10a cell line Intercellular junctions Intercellular force Intercellular adhesome Humans Human cell Human Genetics Desmosomes Desmosome Controlled study Cellular parameters Cell stimulation Cell movement Cell motion Cell migration Cell line Cell junction Cell dynamics Cell communication Cell adhesion molecule Cell adhesion Catenins Catenin Cadherins Cadherin Breast epithelium cell Article Actins Actin
Resum: Dynamics of epithelial tissues determine key processes in development, tissue healing and cancer invasion. These processes are critically influenced by cell-cell adhesion forces. However, the identity of the proteins that resist and transmit forces at cell-cell junctions remains unclear, and how these proteins control tissue dynamics is largely unknown. Here we provide a systematic study of the interplay between cell-cell adhesion proteins, intercellular forces and epithelial tissue dynamics. We show that collective cellular responses to selective perturbations of the intercellular adhesome conform to three mechanical phenotypes. These phenotypes are controlled by different molecular modules and characterized by distinct relationships between cellular kinematics and intercellular forces. We show that these forces and their rates can be predicted by the concentrations of cadherins and catenins. Unexpectedly, we identified different mechanical roles for P-cadherin and E-cadherin; whereas P-cadherin predicts levels of intercellular force, E-cadherin predicts the rate at which intercellular force builds up. © 2015 Macmillan Publishers Limited.
Àrees temàtiques: Medicina veterinaria Medicina i General medicine Ciências biológicas ii Cell biology Biotecnología Biodiversidade Biochemistry & molecular biology
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
Adreça de correu electrònic de l'autor: roger.guimera@urv.cat marta.sales@urv.cat
Identificador de l'autor: 0000-0002-3597-4310 0000-0002-8140-6525
Data d'alta del registre: 2024-10-19
Versió de l'article dipositat: info:eu-repo/semantics/submittedVersion
Enllaç font original: https://www.nature.com/articles/ncb3135
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: Nature Cell Biology. 17 (4): 409-420
Referència de l'ítem segons les normes APA: Bazellieres, Elsa; Conte, Vito; Elosegui-Artola, Alberto; Serra-Picamal, Xavier; Bintanel-Morcillo, Maria; Roca-Cusachs, Pere; Munoz, Jose J; Sales-Pa (2015). Control of cell-cell forces and collective cell dynamics by the intercellular adhesome. Nature Cell Biology, 17(4), 409-420. DOI: 10.1038/ncb3135
DOI de l'article: 10.1038/ncb3135
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2015
Tipus de publicació: Journal Publications