Autor segons l'article: Boronat-Toscano, Albert; Monfort-Ferre, Diandra; Menacho, Margarita; Caro, Aleidis; Bosch, Ramon; Espina, Beatriz; Algaba-Chueca, Francisco; Saera-Vila, Alfonso; Moline, Alicia; Marti, Marc; Espin, Eloy; Millan, Monica; Serena, Carolina;
Departament: Bioquímica i Biotecnologia
Autor/s de la URV: Boronat Toscano, Albert / Bosch Príncep, Ramon / Menacho Viladot, Margarita / Monfort Ferre, Diandra / Serena Perelló, Carolina
Paraules clau: Tnf Stem-cells Obesity Infliximab Immune properties Gut microbiota Diet Creeping fat Adipose tissue Adalimumab
Resum: Anti-TNF biologics have been shown to markedly improve the quality of life for patients with Crohn's disease (CD), yet one-third of patients fail to benefit from this treatment. Patients with CD develop a characteristic wrapping of visceral adipose tissue (VAT) in the inflamed intestinal area, termed creeping fat, and it is known that adipose tissue expansion influences the efficacy of anti-TNF drugs. We questioned whether anti-TNF therapies impact the creeping fat in CD, which might affect the outcome of the disease. Adipose tissue biopsies were obtained from a cohort of 14 patients with CD that received anti-TNF drugs and from 29 non-anti-TNF-treated patients (control group) matched by sex, age, and body mass index undergoing surgical interventions for symptomatic complications. We found that anti-TNF therapies restored adipose tissue morphology and suppressed immune cell infiltration in the creeping fat. Additionally, anti-TNF treatments appeared to markedly improve the pro-inflammatory phenotype of adipose-tissue macrophages and adipose-tissue-derived stem cells. Our study provides evidence that anti-TNF medications influence immune cells and progenitor cells in the creeping of patients with CD, suppressing inflammation. We propose that perilesional VAT should be considered when administering anti-TNF therapy in patients with CD.
Àrees temàtiques: Zootecnia / recursos pesqueiros Spectroscopy Saúde coletiva Química Psicología Physical and theoretical chemistry Organic chemistry Odontología Nutrição Molecular biology Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Inorganic chemistry Geociências Farmacia Engenharias iv Engenharias ii Engenharias i Educação física Computer science applications Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Chemistry, multidisciplinary Catalysis Biotecnología Biodiversidade Biochemistry & molecular biology Astronomia / física
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
Adreça de correu electrònic de l'autor: ramon.bosch@urv.cat margarita.menacho@urv.cat carolina.serena@urv.cat ramon.bosch@urv.cat diandra.monfort@estudiants.urv.cat albert.boronat@estudiants.urv.cat
Identificador de l'autor: 0000-0003-3832-4249
Data d'alta del registre: 2023-09-09
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
Enllaç font original: https://www.mdpi.com/1422-0067/23/19/11170
URL Document de llicència: http://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: International Journal Of Molecular Sciences. 23 (19): 11170-11170
Referència de l'ítem segons les normes APA: Boronat-Toscano, Albert; Monfort-Ferre, Diandra; Menacho, Margarita; Caro, Aleidis; Bosch, Ramon; Espina, Beatriz; Algaba-Chueca, Francisco; Saera-Vil (2022). Anti-TNF Therapies Suppress Adipose Tissue Inflammation in Crohn's Disease. International Journal Of Molecular Sciences, 23(19), 11170-11170. DOI: 10.3390/ijms231911170
DOI de l'article: 10.3390/ijms231911170
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2022
Tipus de publicació: Journal Publications
Repositori URV