Articles producció científica> Bioquímica i Biotecnologia

Circulating carotenoids are associated with favorable lipid and fatty acid profiles in an older population at high cardiovascular risk

  • Dades identificatives

    Identificador: imarina:9283515
    Autors:
    Marhuenda-Muñoz MDomínguez-López ILangohr KTresserra-Rimbau AMartínez González MÁSalas-Salvadó JCorella DZomeño MDMartínez JAAlonso-Gómez AMWärnberg JVioque JRomaguera DLópez-Miranda JEstruch RTinahones FJLapetra JSerra-Majem LBueno-Cavanillas ATur JAMartín-Sánchez VPintó XDelgado-Rodríguez MMatía-Martín PVidal JVázquez CDaimiel LRos EToledo EFernández de la Puente Cervera MBarragán RFitó MTojal-Sierra LGómez-Gracia EZazo JMMorey MGarcía-Ríos ACasas RGómez-Pérez AMSantos-Lozano JMVázquez-Ruiz ZAtzeni AAsensio EMGili-Riu MMBullon VMoreno-Rodriguez ALecea OBabio NPeñas Lopez FGómez Melis GLamuela-Raventós RM
    Resum:
    Carotenoid intake has been reported to be associated with improved cardiovascular health, but there is little information on actual plasma concentrations of these compounds as biomarkers of cardiometabolic risk. The objective was to investigate the association between circulating plasma carotenoids and different cardiometabolic risk factors and the plasma fatty acid profile. This is a cross-sectional evaluation of baseline data conducted in a subcohort (106 women and 124 men) of an ongoing multi-factorial lifestyle trial for primary cardiovascular prevention. Plasma concentrations of carotenoids were quantified by liquid chromatography coupled to mass spectrometry. The associations between carotenoid concentrations and cardiometabolic risk factors were assessed using regression models adapted for interval-censored variables. Carotenoid concentrations were cross-sectionally inversely associated with serum triglyceride concentrations [−2.79 mg/dl (95% CI: −4.25, −1.34) and −5.15 mg/dl (95% CI: −7.38, −2.93), p-values = 0.0002 and <0.00001 in women and men, respectively], lower levels of plasma saturated fatty acids [−0.09% (95% CI: −0.14, −0.03) and −0.15 % (95% CI: −0.23, −0.08), p-values = 0.001 and 0.0001 in women and men, respectively], and higher levels of plasma polyunsaturated fatty acids [(0.12 % (95% CI: −0.01, 0.25) and 0.39 % (95% CI: 0.19, 0.59), p-values = 0.065 and 0.0001 in women and men, respectively] in the whole population. Plasma carotenoid concentrations were also associated with higher plasma HDL-cholesterol in women [0.47 mg/dl (95% CI: 0.23, 0.72), p-value: 0.0002], and lower fasting plasma glucose in men [−1.35 mg/dl (95% CI: −2.12, −0.59), p-value: 0.001].
  • Altres:

    Autor segons l'article: Marhuenda-Muñoz M; Domínguez-López I; Langohr K; Tresserra-Rimbau A; Martínez González MÁ; Salas-Salvadó J; Corella D; Zomeño MD; Martínez JA; Alonso-Gómez AM; Wärnberg J; Vioque J; Romaguera D; López-Miranda J; Estruch R; Tinahones FJ; Lapetra J; Serra-Majem L; Bueno-Cavanillas A; Tur JA; Martín-Sánchez V; Pintó X; Delgado-Rodríguez M; Matía-Martín P; Vidal J; Vázquez C; Daimiel L; Ros E; Toledo E; Fernández de la Puente Cervera M; Barragán R; Fitó M; Tojal-Sierra L; Gómez-Gracia E; Zazo JM; Morey M; García-Ríos A; Casas R; Gómez-Pérez AM; Santos-Lozano JM; Vázquez-Ruiz Z; Atzeni A; Asensio EM; Gili-Riu MM; Bullon V; Moreno-Rodriguez A; Lecea O; Babio N; Peñas Lopez F; Gómez Melis G; Lamuela-Raventós RM
    Departament: Bioquímica i Biotecnologia
    Autor/s de la URV: Babio Sánchez, Nancy Elvira / Salas Salvadó, Jorge
    Paraules clau: Predimed-plus study Plasma carotenoids Mediterranean diet adherence Mediterranean diet Mass spectrometry Liquid chromatography Cardiovascular health survival supplementation serum beta-carotene prevention predimed-plus study plasma carotenoids myocardial-infarction mass spectrometry lycopene liquid chromatography linear-regression model glucose-metabolism diabetes-mellitus cardiovascular health
    Resum: Carotenoid intake has been reported to be associated with improved cardiovascular health, but there is little information on actual plasma concentrations of these compounds as biomarkers of cardiometabolic risk. The objective was to investigate the association between circulating plasma carotenoids and different cardiometabolic risk factors and the plasma fatty acid profile. This is a cross-sectional evaluation of baseline data conducted in a subcohort (106 women and 124 men) of an ongoing multi-factorial lifestyle trial for primary cardiovascular prevention. Plasma concentrations of carotenoids were quantified by liquid chromatography coupled to mass spectrometry. The associations between carotenoid concentrations and cardiometabolic risk factors were assessed using regression models adapted for interval-censored variables. Carotenoid concentrations were cross-sectionally inversely associated with serum triglyceride concentrations [−2.79 mg/dl (95% CI: −4.25, −1.34) and −5.15 mg/dl (95% CI: −7.38, −2.93), p-values = 0.0002 and <0.00001 in women and men, respectively], lower levels of plasma saturated fatty acids [−0.09% (95% CI: −0.14, −0.03) and −0.15 % (95% CI: −0.23, −0.08), p-values = 0.001 and 0.0001 in women and men, respectively], and higher levels of plasma polyunsaturated fatty acids [(0.12 % (95% CI: −0.01, 0.25) and 0.39 % (95% CI: 0.19, 0.59), p-values = 0.065 and 0.0001 in women and men, respectively] in the whole population. Plasma carotenoid concentrations were also associated with higher plasma HDL-cholesterol in women [0.47 mg/dl (95% CI: 0.23, 0.72), p-value: 0.0002], and lower fasting plasma glucose in men [−1.35 mg/dl (95% CI: −2.12, −0.59), p-value: 0.001].
    Àrees temàtiques: Saúde coletiva Nutrition and dietetics Nutrition & dietetics Nutrição Medicina i Interdisciplinar Food science Endocrinology, diabetes and metabolism Educação física
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    Adreça de correu electrònic de l'autor: jordi.salas@urv.cat nancy.babio@urv.cat
    Identificador de l'autor: 0000-0003-2700-7459 0000-0003-3527-5277
    Data d'alta del registre: 2024-09-07
    Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
    Enllaç font original: https://www.frontiersin.org/articles/10.3389/fnut.2022.967967/full
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referència a l'article segons font original: Front Nutr. 9
    Referència de l'ítem segons les normes APA: Marhuenda-Muñoz M; Domínguez-López I; Langohr K; Tresserra-Rimbau A; Martínez González MÁ; Salas-Salvadó J; Corella D; Zomeño MD; Martínez JA; Alonso- (2022). Circulating carotenoids are associated with favorable lipid and fatty acid profiles in an older population at high cardiovascular risk. Front Nutr, 9(), -. DOI: 10.3389/fnut.2022.967967
    DOI de l'article: 10.3389/fnut.2022.967967
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2022
    Tipus de publicació: Journal Publications
  • Paraules clau:

    Endocrinology, Diabetes and Metabolism,Food Science,Nutrition & Dietetics,Nutrition and Dietetics
    Predimed-plus study
    Plasma carotenoids
    Mediterranean diet adherence
    Mediterranean diet
    Mass spectrometry
    Liquid chromatography
    Cardiovascular health
    survival
    supplementation
    serum beta-carotene
    prevention
    predimed-plus study
    plasma carotenoids
    myocardial-infarction
    mass spectrometry
    lycopene
    liquid chromatography
    linear-regression model
    glucose-metabolism
    diabetes-mellitus
    cardiovascular health
    Saúde coletiva
    Nutrition and dietetics
    Nutrition & dietetics
    Nutrição
    Medicina i
    Interdisciplinar
    Food science
    Endocrinology, diabetes and metabolism
    Educação física
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