Autor segons l'article: Auguet, Teresa; Bertran, Laia; Barrientos-Riosalido, Andrea; Fabregat, Blanca; Villar, Beatriz; Aguilar, Carmen; Sabench, Fatima
Departament: Medicina i Cirurgia
Autor/s de la URV: Aguilar Crespillo, Carmen Isabel / Auguet Quintillà, Maria Teresa / Barrientos Riosalido, Andrea / Bertran Ramos, Laia / Sabench Pereferrer, Fàtima / Villar Navas, Beatriz
Paraules clau: Water pollutants, chemical Water Plastics Obesogens Non-alcoholic fatty liver disease Nanoplastics Nafld Microplastics Microbiota Lipids Humans Gut microbiota dysbiosis Animals steatohepatitis pathogenesis particles obesogens obesity nash nanoplastics nafld microbiota metabolism inflammation exposure
Resum: Nonalcoholic fatty liver disease (NAFLD) has emerged as the predominant cause of chronic liver injury; however, the mechanisms underlying its progression have not been fully elucidated. Pathophysiological studies have stated that NAFLD is significantly influenced by dietary and environmental factors that could participate in the development of NAFLD through different mechanisms. Currently, “plastic pollution” is one of the most challenging environmental problems worldwide since several plastics have potential toxic or endocrine disputing properties. Specifically, the intake of microplastics (MPs) and nanoplastics (NPs) in water or diet and/or the inhalation from suspended particles is well established, and these particles have been found in human samples. Laboratory animals exposed to MPs develop inflammation, immunological responses, endocrine disruptions, and alterations in lipid and energy metabolism, among other disorders. MPs additives also demonstrated adverse reactions. There is evidence that MPs and their additives are potential “obesogens” and could participate in NAFLD pathogenesis by modifying gut microbiota composition or even worsen liver fibrosis. Although human exposure to MPs seems clear, their relationship with NAFLD requires further study, since its prevention could be a possible personalized therapeutic strategy. Adequate mitigation strategies worldwide, reducing environmental pollution and human exposure levels of MPs, could reduce the risk of NAFLD.
Àrees temàtiques: Zootecnia / recursos pesqueiros Serviço social Saúde coletiva Química Public, environmental & occupational health Public health, environmental and occupational health Psicología Pollution Odontología Nutrição Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Health, toxicology and mutagenesis Geografía Geociências Farmacia Environmental studies Environmental sciences Ensino Engenharias ii Engenharias i Enfermagem Educação física Educação Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência da computação Biotecnología Biodiversidade Astronomia / física Administração pública e de empresas, ciências contábeis e turismo
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
Adreça de correu electrònic de l'autor: andrea.barrientos@urv.cat andrea.barrientos@urv.cat beatriz.villar@urv.cat beatriz.villar@urv.cat laia.bertranr@estudiants.urv.cat laia.bertranr@estudiants.urv.cat fatima.sabench@urv.cat carmenisabel.aguilar@urv.cat carmenisabel.aguilar@urv.cat mariateresa.auguet@urv.cat
Identificador de l'autor: 0000-0001-9052-1368 0000-0001-9052-1368 0000-0002-9262-8756 0000-0002-4440-562X 0000-0002-4440-562X 0000-0003-0396-6428
Data d'alta del registre: 2024-09-28
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
Enllaç font original: https://www.mdpi.com/1660-4601/19/20/13495
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: International Journal Of Environmental Research And Public Health. 19 (20): 13495-
Referència de l'ítem segons les normes APA: Auguet, Teresa; Bertran, Laia; Barrientos-Riosalido, Andrea; Fabregat, Blanca; Villar, Beatriz; Aguilar, Carmen; Sabench, Fatima (2022). Are Ingested or Inhaled Microplastics Involved in Nonalcoholic Fatty Liver Disease?. International Journal Of Environmental Research And Public Health, 19(20), 13495-. DOI: 10.3390/ijerph192013495
DOI de l'article: 10.3390/ijerph192013495
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2022
Tipus de publicació: Journal Publications