Articles producció científica> Medicina i Cirurgia

Role of kallikrein 7 in body weight and fat mass regulation

  • Dades identificatives

    Identificador: imarina:9287105
    Autors:
    Kunath AWeiner JKrause KRehders MPejkovska AGericke MBiniossek MLDommel SKern MRibas-Latre ASchilling OBrix KStumvoll MKlöting NHeiker JTBlüher M
    Resum:
    Increased plasma and adipose tissue protease activity is observed in patients with type 2 diabetes and obesity. It has been proposed that specific proteases contribute to the link between obesity, adipose tissue inflammation and metabolic diseases. We have recently shown that ablation of the serine protease kallikrein-related peptidase 7 (Klk7) specifically in adipose tissue preserves systemic insulin sensitivity and protects mice from obesity-related AT inflammation. Here, we investigated whether whole body Klk7 knockout (Klk7−/−) mice develop a phenotype distinct from that caused by reduced Klk7 expression in adipose tissue. Compared to littermate controls, Klk7−/− mice gain less body weight and fat mass both under chow and high fat diet (HFD) feeding, are hyper-responsive to exogenous insulin and exhibit preserved adipose tissue function due to adipocyte hyperplasia and lower inflammation. Klk7−/− mice exhibit increased adipose tissue thermogenesis, which is not related to altered thyroid function. These data strengthen our recently proposed role of Klk7 in the regulation of body weight, energy metabolism, and obesity-associated adipose tissue dysfunction. The protective effects of Klk7 deficiency in obesity are likely linked to a significant limitation of adipocyte hypertrophy. In conclusion, our data indicate potential application of specific KLK7 inhibitors to regulate KLK7 activity in the development of obesity and counteract obesity-associated inflammation and metabolic diseases.
  • Altres:

    Autor segons l'article: Kunath A; Weiner J; Krause K; Rehders M; Pejkovska A; Gericke M; Biniossek ML; Dommel S; Kern M; Ribas-Latre A; Schilling O; Brix K; Stumvoll M; Klöting N; Heiker JT; Blüher M
    Departament: Medicina i Cirurgia
    Autor/s de la URV: Ribas Latre, Aleix
    Paraules clau: Treatment Protease Obesity Metabolic disease Klk7 Kallikrein-related peptidase 7 Inhibitor Adipose tissue
    Resum: Increased plasma and adipose tissue protease activity is observed in patients with type 2 diabetes and obesity. It has been proposed that specific proteases contribute to the link between obesity, adipose tissue inflammation and metabolic diseases. We have recently shown that ablation of the serine protease kallikrein-related peptidase 7 (Klk7) specifically in adipose tissue preserves systemic insulin sensitivity and protects mice from obesity-related AT inflammation. Here, we investigated whether whole body Klk7 knockout (Klk7−/−) mice develop a phenotype distinct from that caused by reduced Klk7 expression in adipose tissue. Compared to littermate controls, Klk7−/− mice gain less body weight and fat mass both under chow and high fat diet (HFD) feeding, are hyper-responsive to exogenous insulin and exhibit preserved adipose tissue function due to adipocyte hyperplasia and lower inflammation. Klk7−/− mice exhibit increased adipose tissue thermogenesis, which is not related to altered thyroid function. These data strengthen our recently proposed role of Klk7 in the regulation of body weight, energy metabolism, and obesity-associated adipose tissue dysfunction. The protective effects of Klk7 deficiency in obesity are likely linked to a significant limitation of adipocyte hypertrophy. In conclusion, our data indicate potential application of specific KLK7 inhibitors to regulate KLK7 activity in the development of obesity and counteract obesity-associated inflammation and metabolic diseases.
    Àrees temàtiques: Pharmacology & pharmacy Medicine, research & experimental Medicine (miscellaneous) General biochemistry,genetics and molecular biology Ciencias sociales Biochemistry, genetics and molecular biology (miscellaneous) Biochemistry, genetics and molecular biology (all) Biochemistry & molecular biology
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    Adreça de correu electrònic de l'autor: aleix.ribas@urv.cat
    Data d'alta del registre: 2023-02-18
    Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
    Enllaç font original: https://www.mdpi.com/2227-9059/9/2/131
    Referència a l'article segons font original: Biomedicines. 9 (2): 1-20
    Referència de l'ítem segons les normes APA: Kunath A; Weiner J; Krause K; Rehders M; Pejkovska A; Gericke M; Biniossek ML; Dommel S; Kern M; Ribas-Latre A; Schilling O; Brix K; Stumvoll M; Klöti (2021). Role of kallikrein 7 in body weight and fat mass regulation. Biomedicines, 9(2), 1-20. DOI: 10.3390/biomedicines9020131
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    DOI de l'article: 10.3390/biomedicines9020131
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2021
    Tipus de publicació: Journal Publications
  • Paraules clau:

    Biochemistry & Molecular Biology,Biochemistry, Genetics and Molecular Biology (Miscellaneous),Medicine (Miscellaneous),Medicine, Research & Experimental,Pharmacology & Pharmacy
    Treatment
    Protease
    Obesity
    Metabolic disease
    Klk7
    Kallikrein-related peptidase 7
    Inhibitor
    Adipose tissue
    Pharmacology & pharmacy
    Medicine, research & experimental
    Medicine (miscellaneous)
    General biochemistry,genetics and molecular biology
    Ciencias sociales
    Biochemistry, genetics and molecular biology (miscellaneous)
    Biochemistry, genetics and molecular biology (all)
    Biochemistry & molecular biology
  • Documents:

  • Cerca a google

    Search to google scholar