Autor según el artículo: Kunath A; Weiner J; Krause K; Rehders M; Pejkovska A; Gericke M; Biniossek ML; Dommel S; Kern M; Ribas-Latre A; Schilling O; Brix K; Stumvoll M; Klöting N; Heiker JT; Blüher M
Departamento: Medicina i Cirurgia
Autor/es de la URV: Ribas Latre, Aleix
Palabras clave: Treatment Protease Obesity Metabolic disease Klk7 Kallikrein-related peptidase 7 Inhibitor Adipose tissue
Resumen: Increased plasma and adipose tissue protease activity is observed in patients with type 2 diabetes and obesity. It has been proposed that specific proteases contribute to the link between obesity, adipose tissue inflammation and metabolic diseases. We have recently shown that ablation of the serine protease kallikrein-related peptidase 7 (Klk7) specifically in adipose tissue preserves systemic insulin sensitivity and protects mice from obesity-related AT inflammation. Here, we investigated whether whole body Klk7 knockout (Klk7−/−) mice develop a phenotype distinct from that caused by reduced Klk7 expression in adipose tissue. Compared to littermate controls, Klk7−/− mice gain less body weight and fat mass both under chow and high fat diet (HFD) feeding, are hyper-responsive to exogenous insulin and exhibit preserved adipose tissue function due to adipocyte hyperplasia and lower inflammation. Klk7−/− mice exhibit increased adipose tissue thermogenesis, which is not related to altered thyroid function. These data strengthen our recently proposed role of Klk7 in the regulation of body weight, energy metabolism, and obesity-associated adipose tissue dysfunction. The protective effects of Klk7 deficiency in obesity are likely linked to a significant limitation of adipocyte hypertrophy. In conclusion, our data indicate potential application of specific KLK7 inhibitors to regulate KLK7 activity in the development of obesity and counteract obesity-associated inflammation and metabolic diseases.
Áreas temáticas: Pharmacology & pharmacy Medicine, research & experimental Medicine (miscellaneous) General biochemistry,genetics and molecular biology Ciencias sociales Biochemistry, genetics and molecular biology (miscellaneous) Biochemistry, genetics and molecular biology (all) Biochemistry & molecular biology
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: aleix.ribas@urv.cat
Fecha de alta del registro: 2023-02-18
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: https://www.mdpi.com/2227-9059/9/2/131
URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Biomedicines. 9 (2): 1-20
Referencia de l'ítem segons les normes APA: Kunath A; Weiner J; Krause K; Rehders M; Pejkovska A; Gericke M; Biniossek ML; Dommel S; Kern M; Ribas-Latre A; Schilling O; Brix K; Stumvoll M; Klöti (2021). Role of kallikrein 7 in body weight and fat mass regulation. Biomedicines, 9(2), 1-20. DOI: 10.3390/biomedicines9020131
DOI del artículo: 10.3390/biomedicines9020131
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2021
Tipo de publicación: Journal Publications
Repositori URV