Articles producció científica> Medicina i Cirurgia

Severe infection due to the SARS-CoV-2 coronavirus: Experience of a tertiary hospital with COVID-19 patients during the 2020 pandemic

  • Dades identificatives

    Identificador: imarina:9289774
    Autors:
    Rodriguez, A.Moreno, G.Gomez, J.Carbonell, R.Pico-Plana, E.Benavent Bofill, C.Sanchez Parrilla, R.Trefler, S.Esteve Pitarch, E.Canadell, L.Teixido, X.Claverias, L.Bodi, M.HJ23-Covid-19 Working Grp
    Resum:
    Objective: To describe the clinical and respiratory characteristics of a cohort of 43 patients with COVID-19 after an evolutive period of 28 days.Design: A prospective, single-center observational study was carried out.Setting: Intensive care.Patients: Patients admitted due to COVID-19 and respiratory failure.Interventions: None.Variables: Automatic recording was made of demographic variables, severity parameters, laboratory data, assisted ventilation (HFO: high-flow oxygen therapy and IMV: invasive mechanical ventilation), oxygenation (PaO2, PaO2/FiO(2)) and complications. The patients were divided into three groups: survivors (01), deceased (G2) and patients remaining under admission (03). The chi-squared test or Fisher exact test (categorical variables) was used, along with the Mann Whitney U-test or Wilcoxon test for analyzing the differences between medians. Statistical significance was considered for p<0.05.Results: A total of 43 patients were included (G1-28 [65.1%]; G2= 10 [23.3%] and G3=5 [11.6%]), with a mean age of 65 years (range: 52-72), 62% males, APACHE II 18 (15-24), SOFA 6 (4-7). Arterial hypertension (30.2%) and obesity (25.6%) were the most frequent comorbidities. High -flow oxygen therapy was used in 62.7% of the patients, with failure in 85%. In turn, 95% of the patients required IMV and 85% received ventilation in prone decubitus. In the general population, initial PaO2/FiO(2) improved after 7 days (165 [125-210] vs.194 [153-285]; p=0.02), in the same way as in G1 (164 [125-197] vs. 207 [160-294]; p=0.07), but not in G2 (163 [95-197] vs. 135 [85-177]). No bacterial coinfection was observed. The incidence of IMV-associated pneumonia was high (13 episodes/1000 days of IMV).Conclusions: Patients with COVID-19 require early IMV, a high frequency of ven
  • Altres:

    Autor segons l'article: Rodriguez, A.; Moreno, G.; Gomez, J.; Carbonell, R.; Pico-Plana, E.; Benavent Bofill, C.; Sanchez Parrilla, R.; Trefler, S.; Esteve Pitarch, E.; Canadell, L.; Teixido, X.; Claverias, L.; Bodi, M.;HJ23-Covid-19 Working Grp
    Departament: Medicina i Cirurgia
    Autor/s de la URV: Bodi Saera, Maria Amparo / Canadell Vilarrasa, Laura / Gómez Alvarez, Josep / Rodríguez Oviedo, Alejandro Hugo / TREFLER CRESPO, SANDRA INES
    Paraules clau: Respiratory failure Mectiarlical ventilation Mechanical ventilation Covid-19 Covi d-19
    Resum: Objective: To describe the clinical and respiratory characteristics of a cohort of 43 patients with COVID-19 after an evolutive period of 28 days.Design: A prospective, single-center observational study was carried out.Setting: Intensive care.Patients: Patients admitted due to COVID-19 and respiratory failure.Interventions: None.Variables: Automatic recording was made of demographic variables, severity parameters, laboratory data, assisted ventilation (HFO: high-flow oxygen therapy and IMV: invasive mechanical ventilation), oxygenation (PaO2, PaO2/FiO(2)) and complications. The patients were divided into three groups: survivors (01), deceased (G2) and patients remaining under admission (03). The chi-squared test or Fisher exact test (categorical variables) was used, along with the Mann Whitney U-test or Wilcoxon test for analyzing the differences between medians. Statistical significance was considered for p<0.05.Results: A total of 43 patients were included (G1-28 [65.1%]; G2= 10 [23.3%] and G3=5 [11.6%]), with a mean age of 65 years (range: 52-72), 62% males, APACHE II 18 (15-24), SOFA 6 (4-7). Arterial hypertension (30.2%) and obesity (25.6%) were the most frequent comorbidities. High -flow oxygen therapy was used in 62.7% of the patients, with failure in 85%. In turn, 95% of the patients required IMV and 85% received ventilation in prone decubitus. In the general population, initial PaO2/FiO(2) improved after 7 days (165 [125-210] vs.194 [153-285]; p=0.02), in the same way as in G1 (164 [125-197] vs. 207 [160-294]; p=0.07), but not in G2 (163 [95-197] vs. 135 [85-177]). No bacterial coinfection was observed. The incidence of IMV-associated pneumonia was high (13 episodes/1000 days of IMV).Conclusions: Patients with COVID-19 require early IMV, a high frequency of ventilation in prone decubitus, and have a high incidence of failed HFO. The lack of improvement of PaO2/FiO(2) at 7 days could be a prognostic marker. (C) 2020 Elsevier Espana, S.L.U. y SEMICYUC. All rights reserved.
    Àrees temàtiques: Medicina iii Medicina ii Medicina i General medicine Educação física Critical care medicine Critical care and intensive care medicine
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    Adreça de correu electrònic de l'autor: josep.gomez@urv.cat alejandrohugo.rodriguez@urv.cat laura.canadell@urv.cat mariaamparo.bodi@urv.cat mariaamparo.bodi@urv.cat
    Identificador de l'autor: 0000-0002-0573-7621 0000-0001-8828-5984 0000-0001-7652-8379 0000-0001-7652-8379
    Data d'alta del registre: 2024-06-28
    Versió de l'article dipositat: info:eu-repo/semantics/acceptedVersion
    Enllaç font original: https://www.sciencedirect.com/science/article/pii/S021056912030190X?via%3Dihub
    Referència a l'article segons font original: Medicina Intensiva. 44 (9): 525-533
    Referència de l'ítem segons les normes APA: Rodriguez, A.; Moreno, G.; Gomez, J.; Carbonell, R.; Pico-Plana, E.; Benavent Bofill, C.; Sanchez Parrilla, R.; Trefler, S.; Esteve Pitarch, E.; Canad (2020). Severe infection due to the SARS-CoV-2 coronavirus: Experience of a tertiary hospital with COVID-19 patients during the 2020 pandemic. Medicina Intensiva, 44(9), 525-533. DOI: 10.1016/j.medin.2020.05.018
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    DOI de l'article: 10.1016/j.medin.2020.05.018
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2020
    Tipus de publicació: Journal Publications
  • Paraules clau:

    Critical Care and Intensive Care Medicine,Critical Care Medicine
    Respiratory failure
    Mectiarlical ventilation
    Mechanical ventilation
    Covid-19
    Covi d-19
    Medicina iii
    Medicina ii
    Medicina i
    General medicine
    Educação física
    Critical care medicine
    Critical care and intensive care medicine
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