Articles producció científica> Medicina i Cirurgia

SARS-CoV-2 Serum Viral Load and Prognostic Markers Proposal for COVID-19 Pneumonia in Low-Dose Radiation Therapy Treated Patients

  • Dades identificatives

    Identificador: imarina:9291934
    Autors:
    Piqué, BPeña, KRiu, FAcosta, JCTorres-Royo, LMalave, BAraguas, PBenavides, Rde Febrer, GCamps, JJoven, JArenas, MParada, D
    Resum:
    Several studies have shown that the plasma RNA of SARS-CoV-2 seems to be associated with a worse prognosis of COVID-19. In the present study, we investigated plasma RNA in COVID-19 patients treated with low-dose radiotherapy to determine its prognostic value. Data were collected from the IPACOVID prospective clinical trial (NCT04380818). The study included 46 patients with COVID-19 pneumonia treated with a whole-lung dose of 0.5 Gy. Clinical follow-up, as well as laboratory variables, and SARS-CoV-2 serum viral load, were analyzed before LDRT, at 24 h, and one week after treatment. The mean age of the patients was 85 years, and none received any of the SARS-CoV-2 vaccine doses. The mortality ratio during the course of treatment was 33%. RT-qPCR showed amplification in 23 patients. Higher mortality rate was associated with detectable viremia. Additionally, C-reactive protein, lactate dehydrogenase, and aspartate aminotransferase were significant risk factors associated with COVID-19 mortality. Our present findings show that detectable SARS-CoV-2 plasma viremia 24 h before LDRT is significantly associated with increased mortality rates post-treatment, thus downsizing the treatment success.
  • Altres:

    Autor segons l'article: Piqué, B; Peña, K; Riu, F; Acosta, JC; Torres-Royo, L; Malave, B; Araguas, P; Benavides, R; de Febrer, G; Camps, J; Joven, J; Arenas, M; Parada, D
    Departament: Medicina i Cirurgia
    Autor/s de la URV: Arenas Prat, Meritxell / Camps Andreu, Jorge / Febrer Martínez, Gabriel de / Joven Maried, Jorge / Parada Dominguez, David / Peña Gonzalez, Karla Beatriz / Piqué Smith, Berta / Riu Ferrando, Francisco Pedro
    Paraules clau: Whole-lung irradiation Viral Rna Prognostic Pneumonia Markers Low-dose radiation therapy Load Covid-19 viral rna prognostic pneumonia markers low-dose radiation therapy load coronavirus
    Resum: Several studies have shown that the plasma RNA of SARS-CoV-2 seems to be associated with a worse prognosis of COVID-19. In the present study, we investigated plasma RNA in COVID-19 patients treated with low-dose radiotherapy to determine its prognostic value. Data were collected from the IPACOVID prospective clinical trial (NCT04380818). The study included 46 patients with COVID-19 pneumonia treated with a whole-lung dose of 0.5 Gy. Clinical follow-up, as well as laboratory variables, and SARS-CoV-2 serum viral load, were analyzed before LDRT, at 24 h, and one week after treatment. The mean age of the patients was 85 years, and none received any of the SARS-CoV-2 vaccine doses. The mortality ratio during the course of treatment was 33%. RT-qPCR showed amplification in 23 patients. Higher mortality rate was associated with detectable viremia. Additionally, C-reactive protein, lactate dehydrogenase, and aspartate aminotransferase were significant risk factors associated with COVID-19 mortality. Our present findings show that detectable SARS-CoV-2 plasma viremia 24 h before LDRT is significantly associated with increased mortality rates post-treatment, thus downsizing the treatment success.
    Àrees temàtiques: Medicine, general & internal Medicine (miscellaneous) Medicine (all)
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    Adreça de correu electrònic de l'autor: franciscopedro.riu@urv.cat karlabeatriz.pena@urv.cat david.parada@urv.cat gabrielde.febrer@urv.cat jorge.camps@urv.cat berta.pique@estudiants.urv.cat meritxell.arenas@urv.cat jorge.joven@urv.cat
    Identificador de l'autor: 0000-0002-3165-3640 0000-0003-0815-2570 0000-0003-2749-4541
    Data d'alta del registre: 2024-08-03
    Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
    Enllaç font original: https://www.mdpi.com/2077-0383/12/3/798
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referència a l'article segons font original: Journal Of Clinical Medicine. 12 (3):
    Referència de l'ítem segons les normes APA: Piqué, B; Peña, K; Riu, F; Acosta, JC; Torres-Royo, L; Malave, B; Araguas, P; Benavides, R; de Febrer, G; Camps, J; Joven, J; Arenas, M; Parada, D (2023). SARS-CoV-2 Serum Viral Load and Prognostic Markers Proposal for COVID-19 Pneumonia in Low-Dose Radiation Therapy Treated Patients. Journal Of Clinical Medicine, 12(3), -. DOI: 10.3390/jcm12030798
    DOI de l'article: 10.3390/jcm12030798
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2023
    Tipus de publicació: Journal Publications
  • Paraules clau:

    Medicine (Miscellaneous),Medicine, General & Internal
    Whole-lung irradiation
    Viral
    Rna
    Prognostic
    Pneumonia
    Markers
    Low-dose radiation therapy
    Load
    Covid-19
    viral
    rna
    prognostic
    pneumonia
    markers
    low-dose radiation therapy
    load
    coronavirus
    Medicine, general & internal
    Medicine (miscellaneous)
    Medicine (all)
  • Documents:

  • Cerca a google

    Search to google scholar