Author, as appears in the article.: Piqué B; Peña K; Riu F; Acosta JC; Torres-Royo L; Malave B; Araguas P; Benavides R; de Febrer G; Camps J; Joven J; Arenas M; Parada D

Department: Medicina i Cirurgia

URV's Author/s: Arenas Prat, Meritxell / Camps Andreu, Jorge / Febrer Martínez, Gabriel de / Joven Maried, Jorge / Piqué Smith, Berta

Keywords: Whole-lung irradiation Viral Rna Prognostic Pneumonia Markers Low-dose radiation therapy Load Covid-19 viral rna prognostic pneumonia markers low-dose radiation therapy load coronavirus

Abstract: Several studies have shown that the plasma RNA of SARS-CoV-2 seems to be associated with a worse prognosis of COVID-19. In the present study, we investigated plasma RNA in COVID-19 patients treated with low-dose radiotherapy to determine its prognostic value. Data were collected from the IPACOVID prospective clinical trial (NCT04380818). The study included 46 patients with COVID-19 pneumonia treated with a whole-lung dose of 0.5 Gy. Clinical follow-up, as well as laboratory variables, and SARS-CoV-2 serum viral load, were analyzed before LDRT, at 24 h, and one week after treatment. The mean age of the patients was 85 years, and none received any of the SARS-CoV-2 vaccine doses. The mortality ratio during the course of treatment was 33%. RT-qPCR showed amplification in 23 patients. Higher mortality rate was associated with detectable viremia. Additionally, C-reactive protein, lactate dehydrogenase, and aspartate aminotransferase were significant risk factors associated with COVID-19 mortality. Our present findings show that detectable SARS-CoV-2 plasma viremia 24 h before LDRT is significantly associated with increased mortality rates post-treatment, thus downsizing the treatment success.

Thematic Areas: Medicine, general & internal Medicine (miscellaneous) Medicine (all)

licence for use: https://creativecommons.org/licenses/by/3.0/es/

Author's mail: gabrielde.febrer@urv.cat jorge.camps@urv.cat jorge.joven@urv.cat meritxell.arenas@urv.cat berta.pique@estudiants.urv.cat

Author identifier: 0000-0002-3165-3640 0000-0003-2749-4541 0000-0003-0815-2570

Record's date: 2023-03-18

Papper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://www.mdpi.com/2077-0383/12/3/798

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Journal Of Clinical Medicine. 12 (3):

APA: Piqué B; Peña K; Riu F; Acosta JC; Torres-Royo L; Malave B; Araguas P; Benavides R; de Febrer G; Camps J; Joven J; Arenas M; Parada D (2023). SARS-CoV-2 Serum Viral Load and Prognostic Markers Proposal for COVID-19 Pneumonia in Low-Dose Radiation Therapy Treated Patients. Journal Of Clinical Medicine, 12(3), -. DOI: 10.3390/jcm12030798

Article's DOI: 10.3390/jcm12030798

Entity: Universitat Rovira i Virgili

Journal publication year: 2023

Publication Type: Journal Publications