Autor segons l'article: Parra, Sandra; Marsillach, Judit; Aragones, Gerard; Beltran, Raul; Montero, Manuel; Coll, Blai; Mackness, Bharti; Mackness, Michael; Alonso-Villaverde, Carlos; Joven, Jorge; Camps, Jordi;
Departament: Bioquímica i Biotecnologia Medicina i Cirurgia
Autor/s de la URV: Aragonès Bargalló, Gerard / Beltrán Debón, Raúl Alejandro / Camps Andreu, Jorge / Joven Maried, Jorge / MARSILLACH LÓPEZ, JUDIT / Montero Jaime, Manuel Jesus / Parra Pérez, Sandra
Paraules clau: Serum Risk-factor Proteins Pon1 Polymorphisms Life-style High-density-lipoprotein Coronary-heart-disease
Resum: Background. Oxidative stress is associated with human immunodeficiency virus (HIV) infection. Paraoxonase-1 (PON1) is an antioxidant enzyme that is bound to high-density lipoproteins (HDLs). We evaluated whether PON1 gene haplotypes influence the metabolic disturbances, presence of subclinical atherosclerosis, and virologic outcome associated with the infection.Methods. DNA from blood samples collected from 234 HIV-infected patients and 633 healthy control subjects had single-nucleotide polymorphisms of PON1(192), PON1(55), PON1(-162), PON1(-832), PON1(-909), PON1(-1076), and PON1(-1741) analyzed using the Iplex Gold MassArray method. Subsequently, the influence of these single-nucleotide polymorphisms on measured biochemical and clinical variables was assessed.Results. We observed significant differences in the haplotype distribution between the control subjects and the HIV-infected patients. Haplotype H10 (GTCCGTC) was more prevalent in the HIV-infected patients (6.41% vs 0.64%; P < .001), and haplotype H5 (GACCGTC) was less prevalent in HIV-infected patients (27.7% vs 42.9%; P = .001). In HIV-infected patients, haplotype H7 (AATTCCT) was associated with better CD4(+) cell count recovery, higher levels of HDL cholesterol (P = .048) and apolipoprotein A-I (P = .019), lower levels of triglycerides (P = .004), and lower rates of subclinical arteriosclerosis (P < .001).Conclusions. PON1 haplotypes segregate with HIV infection, HDL metabolism, the presence of subclinical atherosclerosis, and CD4(+) cell recovery after treatment.
Àrees temàtiques: Zootecnia / recursos pesqueiros Saúde coletiva Odontología Microbiology Medicine (all) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Infectious diseases Immunology and allergy Immunology General medicine Farmacia Engenharias iv Enfermagem Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Biotecnología Biodiversidade
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
Adreça de correu electrònic de l'autor: manueljesus.montero@urv.cat jorge.camps@urv.cat sandra.parra@urv.cat jorge.joven@urv.cat gerard.aragones@urv.cat raul.beltran@urv.cat
Identificador de l'autor: 0000-0002-3165-3640 0000-0001-9363-6574 0000-0003-2749-4541 0000-0001-9691-1906
Data d'alta del registre: 2024-09-07
Versió de l'article dipositat: info:eu-repo/semantics/submittedVersion
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: Journal Of Infectious Diseases. 201 (4): 627-634
Referència de l'ítem segons les normes APA: Parra, Sandra; Marsillach, Judit; Aragones, Gerard; Beltran, Raul; Montero, Manuel; Coll, Blai; Mackness, Bharti; Mackness, Michael; Alonso-Villaverde (2010). Paraoxonase-1 Gene Haplotypes Are Associated with Metabolic Disturbances, Atherosclerosis, and Immunologic Outcome in HIV-Infected Patients. Journal Of Infectious Diseases, 201(4), 627-634. DOI: 10.1086/650312
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2010
Tipus de publicació: Journal Publications
Repositori URV