Autor segons l'article: Simon-Muela, Inmaculada; Naf, Silvia; Ballesteros, Monica; Vendrell, Joan; Ceperuelo-Mallafre, Victoria; de la Flor, Miriam; Megia, Ana;
Departament: Medicina i Cirurgia
Autor/s de la URV: Ballesteros Pérez, Monica / Ceperuelo Mallafré, Maria Victoria / De la Flor López, Miriam José / Megía Colet, Ana / Naf Cortés, Silvia Daniela / Simón Muela, María Inmaculada / Vendrell Ortega, Juan José
Paraules clau: Pregnancies Neonatal adiposity Maternal serum adiponectin Leptin Intrauterine growth Glucose Fetal growth Diabetes-mellitus Cord blood Body-fat Birth-weight Age Adiponectin
Resum: OBJECTIVE: We sought to analyze the role of cord blood adiponectin and its multimeric forms in neonatal adiposity and fetal growth velocity (FGV) during the third trimester of pregnancy according to fetal gender.STUDY DESIGN: This was a prospective analytical observational study conducted at the Diabetes and Pregnancy Unit, University Hospital Joan XXIII, Tarragona, Spain. In all, 96 healthy pregnant women were included in the early third trimester and were followed up until delivery. Maternal blood was obtained upon recruitment, and cord blood was obtained at delivery. Serial fetal ultrasounds were performed during the third trimester to assess FGV. Skinfolds were measured after birth to assess neonatal adiposity. Adiponectin multimers were determined in maternal and cord blood.RESULTS: In female neonates, adiposity and FGV in the late third trimester were correlated positively with cord blood insulin (r = 0.343, P = .015 and r = 0.430, P = .002, respectively) and maternal pregravid body mass index (r = 597, P < .001 and r = 0.428, P = .002, respectively), and negatively with maternal high-molecular-weight (HMW)/total adiponectin ratio (r = -0.269, P = .035 and r = -0.387, P = .005, respectively), but in the stepwise multiple regression model, the main determinants were cord blood insulin, pregravid body mass index, and cord blood HMW adiponectin. Otherwise, in male neonates, adiposity and fetal growth were correlated with cord blood low-molecular-weight adiponectin (r = 0.486, P = .003 and r = 0.394, P = .020, respectively), and it was this multimeric form that emerged as an independent determinant in the stepwise regression model.CONCLUSION: Adiponectin seems to determine fetal growth and adipose tissue accretion, and low molecular weight is more specifically implicated in males, whereas the HMW isoform may be more important in females.
Àrees temàtiques: Saúde coletiva Odontología Obstetrics and gynecology Obstetrics & gynecology Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Farmacia Engenharias iv Ciências biológicas ii Ciências biológicas i Biotecnología Biodiversidade
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
Adreça de correu electrònic de l'autor: monica.ballesteros@urv.cat miriamjose.delaflor@urv.cat silviadaniela.naf@urv.cat victoria.ceperuelo@urv.cat juanjose.vendrell@urv.cat ana.megia@urv.cat
Identificador de l'autor: 0000-0002-4460-9761 0000-0002-6994-6115 0000-0002-5101-9452
Data d'alta del registre: 2024-01-27
Versió de l'article dipositat: info:eu-repo/semantics/acceptedVersion
Enllaç font original: https://www.sciencedirect.com/science/article/abs/pii/S0002937813002408
Referència a l'article segons font original: American Journal Of Obstetrics And Gynecology. 208 (6):
Referència de l'ítem segons les normes APA: Simon-Muela, Inmaculada; Naf, Silvia; Ballesteros, Monica; Vendrell, Joan; Ceperuelo-Mallafre, Victoria; de la Flor, Miriam; Megia, Ana; (2013). Gender determines the actions of adiponectin multimers on fetal growth and adiposity. American Journal Of Obstetrics And Gynecology, 208(6), -. DOI: 10.1016/j.ajog.2013.02.045
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
DOI de l'article: 10.1016/j.ajog.2013.02.045
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2013
Tipus de publicació: Journal Publications
Repositori URV