Articles producció científicaBioquímica i Biotecnologia

Murine Model of a Disseminated Infection by the Novel Fungus Fonsecaea monophora and Successful Treatment with Posaconazole

  • Dades identificatives

    Identificador:  imarina:9298547
    Handle: https://hdl.handle.net/20.500.11797/imarina9298547
    Autors:  Calvo, E; Pastor, FJ; Rodríguez, MM; Mayayo, E; Salas, V; Guarro, J
    Resum:
    We have evaluated the efficacy of posaconazole, amphotericin B, and itraconazole in a murine model of disseminated infection by Fonsecaea monophora. Of these three antifungal drugs tested, posaconazole prolonged survival significantly and reduced the fungal load in most of the organs tested. Bioassay studies demonstrated the relationship between posaconazole levels and dose escalation in serum and brain tissue. Posaconazole may have a clinical role in the treatment of disseminated infections by F. monophora.

  • Altres:

    Referència de l'ítem segons les normes APA: Calvo, E; Pastor, FJ; Rodríguez, MM; Mayayo, E; Salas, V; Guarro, J (2010). Murine Model of a Disseminated Infection by the Novel Fungus Fonsecaea monophora and Successful Treatment with Posaconazole. Antimicrobial Agents And Chemotherapy, 54(2), 919-923. DOI: 10.1128/AAC.01284-09
    Referència a l'article segons font original: Antimicrobial Agents And Chemotherapy. 54 (2): 919-923
    DOI de l'article: 10.1128/AAC.01284-09
    Any de publicació de la revista: 2010-02-01
    Entitat: Universitat Rovira i Virgili
    Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
    Data d'alta del registre: 2026-05-09
    Autor/s de la URV: Calvo Manso, Enrique / Guarro Artigas, Josep / Mayayo Artal, Emilio Manuel / PASTOR MOLAS, FRANCISCO JAVIER / SALAS CIFUENTES, VALENTINA LIDIA
    Departament: Bioquímica i Biotecnologia
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    Tipus de publicació: Journal Publications
    Autor segons l'article: Calvo, E; Pastor, FJ; Rodríguez, MM; Mayayo, E; Salas, V; Guarro, J
    Àrees temàtiques: Pharmacology (medical), Pharmacology & pharmacy, Pharmacology, Microbiology, Infectious diseases, Biotecnología, Biodiversidade, Administração pública e de empresas, ciências contábeis e turismo
    Adreça de correu electrònic de l'autor: enrique.calvo@urv.cat, enrique.calvo@urv.cat, enrique.calvo@urv.cat

  • Paraules clau:

    Pheohyphomycosis
    Infectious Diseases
    Microbiology
    Pharmacology
    Pharmacology & Pharmacy
    Pharmacology (Medical)
    Biotecnología
    Biodiversidade
    Administração pública e de empresas
    ciências contábeis e turismo

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