Murine Model of a Disseminated Infection by the Novel Fungus Fonsecaea monophora and Successful Treatment with Posaconazole

Autor segons l'article: Calvo, Enrique; Javier Pastor, F; Mar Rodriguez, M; Mayayo, Emilio; Salas, Valentina; Guarro, Josep

Departament: Bioquímica i Biotecnologia

Autor/s de la URV: Calvo Manso, Enrique / Guarro Artigas, Josep / Mayayo Artal, Emilio Manuel / PASTOR MOLAS, FRANCISCO JAVIER / SALAS CIFUENTES, VALENTINA LIDIA

Paraules clau: Pheohyphomycosis

Resum: We have evaluated the efficacy of posaconazole, amphotericin B, and itraconazole in a murine model of disseminated infection by Fonsecaea monophora. Of these three antifungal drugs tested, posaconazole prolonged survival significantly and reduced the fungal load in most of the organs tested. Bioassay studies demonstrated the relationship between posaconazole levels and dose escalation in serum and brain tissue. Posaconazole may have a clinical role in the treatment of disseminated infections by F. monophora.

Àrees temàtiques: Saúde coletiva; Química; Pharmacology (medical); Pharmacology & pharmacy; Pharmacology; Odontología; Nutrição; Microbiology; Medicina veterinaria; Medicina iii; Medicina ii; Medicina i; Materiais; Matemática / probabilidade e estatística; Interdisciplinar; Infectious diseases; Farmacia; Ensino; Engenharias iv; Engenharias iii; Engenharias ii; Enfermagem; Educação física; Educação; Ciências biológicas iii; Ciências biológicas ii; Ciências biológicas i; Ciências agrárias i; Ciência de alimentos; Biotecnología; Biodiversidade; Astronomia / física

Adreça de correu electrònic de l'autor: enrique.calvo@urv.cat

Data d'alta del registre: 2025-01-28

Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion

URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/

Referència a l'article segons font original: Antimicrobial Agents And Chemotherapy. 54 (2): 919-923

Referència de l'ítem segons les normes APA: Calvo, Enrique; Javier Pastor, F; Mar Rodriguez, M; Mayayo, Emilio; Salas, Valentina; Guarro, Josep (2010). Murine Model of a Disseminated Infection by the Novel Fungus Fonsecaea monophora and Successful Treatment with Posaconazole. Antimicrobial Agents And Chemotherapy, 54(2), 919-923. DOI: 10.1128/AAC.01284-09

DOI de l'article: 10.1128/AAC.01284-09

Entitat: Universitat Rovira i Virgili

Any de publicació de la revista: 2010

Tipus de publicació: Journal Publications