Articles producció científicaBioquímica i Biotecnologia

Murine Model of a Disseminated Infection by the Novel Fungus Fonsecaea monophora and Successful Treatment with Posaconazole

  • Identification data

    Identifier:  imarina:9298547
    Handle: https://hdl.handle.net/20.500.11797/imarina9298547
    Authors:  Calvo, Enrique; Javier Pastor, F; Mar Rodriguez, M; Mayayo, Emilio; Salas, Valentina; Guarro, Josep
    Abstract:
    We have evaluated the efficacy of posaconazole, amphotericin B, and itraconazole in a murine model of disseminated infection by Fonsecaea monophora. Of these three antifungal drugs tested, posaconazole prolonged survival significantly and reduced the fungal load in most of the organs tested. Bioassay studies demonstrated the relationship between posaconazole levels and dose escalation in serum and brain tissue. Posaconazole may have a clinical role in the treatment of disseminated infections by F. monophora.

  • Others:

    APA: Calvo, Enrique; Javier Pastor, F; Mar Rodriguez, M; Mayayo, Emilio; Salas, Valentina; Guarro, Josep (2010). Murine Model of a Disseminated Infection by the Novel Fungus Fonsecaea monophora and Successful Treatment with Posaconazole. Antimicrobial Agents And Chemotherapy, 54(2), 919-923. DOI: 10.1128/AAC.01284-09
    Paper original source: Antimicrobial Agents And Chemotherapy. 54 (2): 919-923
    Article's DOI: 10.1128/AAC.01284-09
    Journal publication year: 2010
    Entity: Universitat Rovira i Virgili
    Paper version: info:eu-repo/semantics/publishedVersion
    Record's date: 2025-01-28
    URV's Author/s: Calvo Manso, Enrique / Guarro Artigas, Josep / Mayayo Artal, Emilio Manuel / PASTOR MOLAS, FRANCISCO JAVIER / SALAS CIFUENTES, VALENTINA LIDIA
    Department: Bioquímica i Biotecnologia
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Publication Type: Journal Publications
    Author, as appears in the article.: Calvo, Enrique; Javier Pastor, F; Mar Rodriguez, M; Mayayo, Emilio; Salas, Valentina; Guarro, Josep
    Thematic Areas: Saúde coletiva, Química, Pharmacology (medical), Pharmacology & pharmacy, Pharmacology, Odontología, Nutrição, Microbiology, Medicina veterinaria, Medicina iii, Medicina ii, Medicina i, Materiais, Matemática / probabilidade e estatística, Interdisciplinar, Infectious diseases, Farmacia, Ensino, Engenharias iv, Engenharias iii, Engenharias ii, Enfermagem, Educação física, Educação, Ciências biológicas iii, Ciências biológicas ii, Ciências biológicas i, Ciências agrárias i, Ciência de alimentos, Biotecnología, Biodiversidade, Astronomia / física
    Author's mail: enrique.calvo@urv.cat

  • Keywords:

    Pheohyphomycosis
    Infectious Diseases
    Microbiology
    Pharmacology
    Pharmacology & Pharmacy
    Pharmacology (Medical)
    Saúde coletiva
    Química
    Odontología
    Nutrição
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Materiais
    Matemática / probabilidade e estatística
    Interdisciplinar
    Farmacia
    Ensino
    Engenharias iv
    Engenharias iii
    Engenharias ii
    Enfermagem
    Educação física
    Educação
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências agrárias i
    Ciência de alimentos
    Biotecnología
    Biodiversidade
    Astronomia / física

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