Articles producció científicaBioquímica i Biotecnologia

Murine Model of a Disseminated Infection by the Novel Fungus Fonsecaea monophora and Successful Treatment with Posaconazole

  • Identification data

    Identifier:  imarina:9298547
    Handle: https://hdl.handle.net/20.500.11797/imarina9298547
    Authors:  Calvo, E; Pastor, FJ; Rodríguez, MM; Mayayo, E; Salas, V; Guarro, J
    Abstract:
    We have evaluated the efficacy of posaconazole, amphotericin B, and itraconazole in a murine model of disseminated infection by Fonsecaea monophora. Of these three antifungal drugs tested, posaconazole prolonged survival significantly and reduced the fungal load in most of the organs tested. Bioassay studies demonstrated the relationship between posaconazole levels and dose escalation in serum and brain tissue. Posaconazole may have a clinical role in the treatment of disseminated infections by F. monophora.

  • Others:

    APA: Calvo, E; Pastor, FJ; Rodríguez, MM; Mayayo, E; Salas, V; Guarro, J (2010). Murine Model of a Disseminated Infection by the Novel Fungus Fonsecaea monophora and Successful Treatment with Posaconazole. Antimicrobial Agents And Chemotherapy, 54(2), 919-923. DOI: 10.1128/AAC.01284-09
    Paper original source: Antimicrobial Agents And Chemotherapy. 54 (2): 919-923
    Article's DOI: 10.1128/AAC.01284-09
    Journal publication year: 2010-02-01
    Entity: Universitat Rovira i Virgili
    Paper version: info:eu-repo/semantics/publishedVersion
    Record's date: 2026-05-09
    URV's Author/s: Calvo Manso, Enrique / Guarro Artigas, Josep / Mayayo Artal, Emilio Manuel / PASTOR MOLAS, FRANCISCO JAVIER / SALAS CIFUENTES, VALENTINA LIDIA
    Department: Bioquímica i Biotecnologia
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Publication Type: Journal Publications
    Author, as appears in the article.: Calvo, E; Pastor, FJ; Rodríguez, MM; Mayayo, E; Salas, V; Guarro, J
    Thematic Areas: Pharmacology (medical), Pharmacology & pharmacy, Pharmacology, Microbiology, Infectious diseases, Biotecnología, Biodiversidade, Administração pública e de empresas, ciências contábeis e turismo
    Author's mail: enrique.calvo@urv.cat, enrique.calvo@urv.cat, enrique.calvo@urv.cat

  • Keywords:

    Pheohyphomycosis
    Infectious Diseases
    Microbiology
    Pharmacology
    Pharmacology & Pharmacy
    Pharmacology (Medical)
    Biotecnología
    Biodiversidade
    Administração pública e de empresas
    ciências contábeis e turismo

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