Autor segons l'article: Guardia-Escote, L; Biosca-Brull, J; Cabré, M; Blanco, J; Mladenova-Koleva, M; Basaure, P; Pérez-Fernández, C; Sánchez-Santed, F; Domingo, JL; Colomina, MT
Departament: Psicologia Ciències Mèdiques Bàsiques Bioquímica i Biotecnologia
Autor/s de la URV: BASAURE GARCÍA, PÍA ISABEL / Biosca Brull, Judit / Blanco Pérez, Jordi / Cabré Bargalló, Maria / Colomina Fosch, Maria Teresa / Domingo Roig, José Luis / Guardia Escoté, Laia
Paraules clau: Lipidomics Chlorpyrifos Central-nervous-system Brain development Apoe targeted replacement susceptibility neurotoxicity metabolism lipids insecticide chlorpyrifos cholesterol chlorpyrifos brain development apolipoprotein-e apoe alzheimers-disease
Resum: Lipids are a major component of the brain, and are involved in structural and neurodevelopmental processes such as neurogenesis, synaptogenesis and signaling. Apolipoprotein E (apoE) is the main lipoprotein involved in lipid transport in the brain. The apoE isoforms can determine vulnerability to the toxic effects of the pesticide chlorpyrifos (CPF), which can interfere with normal neurodevelopment. We aimed to study the effects of postnatal exposure to CPF and of the APOE genotype on the lipid composition of the brain at early ages. For it, we used apoE3 and apoE4 targeted-replacement (TR) male mice, as well as wild-type C57BL/6. The mice were orally exposed to 1 mg/kg/day of CPF on postnatal days 10-15 and, four hours after the treatment, we obtained samples to assess the cerebral lipid composition. Differences between APOE genotypes were found in the cerebral lipid profile in the postnatal period. ApoE4-TR mice exhibited higher lipid concentrations compared to the other groups in most of the cases. CPF exposure led to a decrease in cholesteryl ester and triglyceride concentrations, while modulating the levels of phosphatidylcholine species based on the apoE isoform. Specifically, CPF treatment decreased the concentration of some species of this lipid (PC30:0, PC31:0, PC32:2, PC36:5, PC40:4 and PC40:5) in C57BL/6 mice exposed to CPF, increased (PC31:0 and PC37:6) in apoE3-TR exposed mice while exposed apoE4-TR mice remained unaltered. These results provide further insights into the lipid composition of the brain at early ages, and how it can be modulated by environmental and genetic factors.© 2023. The Author(s).
Àrees temàtiques: Toxicology Saúde coletiva Química Psicología Odontología Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Health, toxicology and mutagenesis General medicine Farmacia Engenharias iii Engenharias i Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciência de alimentos Biotecnología Biodiversidade
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
Adreça de correu electrònic de l'autor: jordi.blanco@urv.cat maria.cabre@urv.cat judit.biosca@urv.cat judit.biosca@urv.cat joseluis.domingo@urv.cat mariateresa.colomina@urv.cat
Identificador de l'autor: 0000-0001-8016-0984 0000-0003-4124-8603 0000-0001-6647-9470 0000-0002-5619-4874
Data d'alta del registre: 2024-08-03
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
Enllaç font original: https://link.springer.com/article/10.1007/s00204-023-03555-8
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: Archives Of Toxicology. 97 (9): 2463-2475
Referència de l'ítem segons les normes APA: Guardia-Escote, L; Biosca-Brull, J; Cabré, M; Blanco, J; Mladenova-Koleva, M; Basaure, P; Pérez-Fernández, C; Sánchez-Santed, F; Domingo, JL; Colomina (2023). Developmental brain lipidomics is influenced by postnatal chlorpyrifos exposure and APOE genetic background in mice. Archives Of Toxicology, 97(9), 2463-2475. DOI: 10.1007/s00204-023-03555-8
DOI de l'article: 10.1007/s00204-023-03555-8
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2023
Tipus de publicació: Journal Publications